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PubMed | Coimbatore Medical College Hospital, Assistant Professor., Postgraduate. and Tamil University
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

Case reports of Wilsons disease occurring in combination with SLE are rarely reported in literature. Drug induced lupus have been observed in patients taking D-penicillamine for Wilsons disease. Here we report a case from Coimbatore Medical College hospital, who presented with fever and neuropsychiatric symptoms as the initial manifestation and found to have both SLE and Wilsons disease on subsequent evaluation.


PubMed | Coimbatore Medical College Hospital, Assistant Professor., Postgraduate. and Tamil University
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

Lipemia retinalis is a rare and asymptomatic condition which occurs when high levels of triglycerides and chylomicrons are present in blood. We report a rare case of secondary hyperlipoproteinemia in a 27 year old type 1 diabetes patient who presented with diabetic ketoacidosis and this peculiar ocular manifestation. The fundoscopic abnormality and creamy white serum cleared as the level of chylomicrons in the plasma dropped with intensive insulin therapy.


PubMed | Coimbatore Medical College Hospital, Assistant Professor., Postgraduate. and Tamil University
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

Unilateral pulmonary artery agenesis (UPAA) is a rare congenital anomaly due to a malformation of the sixth aortic arch of the affected side during embryogenesis. It can occur in isolation or may be associated with other congenital cardiovascular malformations. The diagnosis is usually set at adolescence, however it can remain asymptomatic and late diagnosis is possible. Recurrent pulmonary infections, decreased exercise tolerance, and shortness of breath on exertion are the most common symptoms.


Sivanmani K.,Coimbatore Medical College Hospital | Rajathinakar V.,Coimbatore Medical College Hospital
Indian Journal of Occupational and Environmental Medicine | Year: 2013

Introduction: Silicosis in Coimbatore district of Tamil Nadu: A passive surveillance study. Aim: This study was done to describe the level of preventive measures and level of awareness among the patients diagnosed with silicosis during a one-year period. Settings and Design: Coimbatore Medical College Hospital. Materials and Methods: This is a passive surveillance study based on patients diagnosed with silicosis in our outpatient facility for a one-year period between January 1, 2012 and December 31, 2012. Results: Seventeen cases of silicosis were diagnosed based on history of exposure to silica and radiological features. The mean age was 55 years with 16 males and one female. The average duration of exposure was 22 years. A protective mask was used by 29% of the patients and one patient had awareness about the risks of exposure to silica. Active tuberculosis was found in 12% and old tuberculosis in 47% of patients; 59% of the patients were smokers. Spirometry showed a restrictive pattern in 59% of the patients. Radiologically nodular opacities with upper-zone predominance was found in majority of the cases. Conclusion: Most patients are exposed to silica in unorganized industries. Majority of the patients lack awareness about the disease and there is a low implementation of preventive and control measures. As this study was a passive surveillance, it represents only the tip of iceberg and an active field-level surveillance could reveal the true prevalence of this disease.


Karthikeyan G.,Coimbatore Medical College Hospital | Ratnakumari T.L.,Coimbatore Medical College Hospital
Indian Pediatrics | Year: 2013

From August 2004 to July 2005 at Coimbatore Medical College Hospital, Tamilnadu, the process of issuing well baby certificate to 1668 babies of 1658 mothers electing to undergo puerperal sterilization within a week of delivery was analyzed. 1553 babies (93.1%) were issued well baby certificates. Certificates were deferred in 88 babies (5.3%) and it was refused in 27 (1.6%). Reasons are analyzed and discussed. © 2013 Indian Academy of Pediatrics.


Ravishankaran P.,Coimbatore Medical College Hospital | Rajamani G.,Coimbatore Medical College Hospital
Journal of Indian Association of Pediatric Surgeons | Year: 2010

We report a 28-day-old neonate presenting with signs of fever, abdominal distension, and refusal to feed. The baby was diagnosed to have multiple liver abscesses which ruptured and a tract lead to the pericardium resulting in a pyo-pericardium. Laparoscopic drainage of the abscess cavities and the pyo-pericardium was performed. An extensive search of the literature revealed that this case is the youngest one to have undergone such simultaneous laparoscopic drainage.


Ravishankaran P.,Coimbatore Medical College Hospital | Karunanithi R.,Ganga Hospital
World Journal of Surgical Oncology | Year: 2011

Background: Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the disease. The primary objective of this study was to determine the preoperative serum levels of IL-6 and CRP in breast carcinoma, and to correlate them with the staging of the disease and the prognosis.Methods: 59 female patients admitted for breast cancer were identified for the study and were subjected to thorough evaluation. Serum levels of IL-6 were assessed via Enzyme-Linked Immuno-Sorbent Assay (ELISA), and CRP was measured via immunoturbidimetry. Histological findings included tumour size, lymph node (LN) metastasis, and tumour staging. Relevant investigations were made to find out the presence of distant metastasis. Statistical analysis of the data was then processed.Results: Increases in cancer invasion and staging are generally associated with increases in preoperative serum IL-6 levels. IL-6 and CRP levels correlated with LN metastasis (P < 0.001, P < 0.001) and TNM stage (P < 0.001, P < 0.001). Tumour invasion and the presence of distant metastasis is associated with higher IL-6 levels (P = 0.001, P = 0.009). When we established the cutoff value for IL-6 level (20.55 pg/dl) by ROC curve, we noted a significant difference in overall survival (OS; P = 0.008). However, CRP evidenced no significance with regard to patient's OS levels. Serum IL-6 levels were correlated positively with CRP levels (r2 = 0.579, P < 0.01). Conclusion: Serum levels of IL-6 correlates well with the extent of tumor invasion, LN metastasis, distant metastasis and TNM staging thus enveloping all aspects of breast cancer. © 2011 Ravishankaran and Karunanithi; licensee BioMed Central Ltd.


PubMed | Taluk Hospital and Coimbatore Medical College Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2017

Probiotics are known to reduce the severity of hyperbilirubinemia.This study was done to evaluate the effect of probiotic on neonatal hyperbilirubinemia in term neonates.A total of 181 healthy term neonates after birth were divided into a control group (n=95) and a treatment group (n=86) randomly and treated with placebo and probiotic (On day 3, mean total serum bilirubin in control group among patient who has not developed clinical jaundice is 6.5mg% and in the treatment group is 5mg%. In patient with clinical jaundice, it is 13.6mg% in control group and 10.7mg% in the treatment group. The p-value was found to be <0.05 which is statistically significant. No obvious adverse reactions noted in either group.Probiotics lowered the serum bilirubin level of healthy neonate with jaundice safely and significantly without any adverse reaction.


PubMed | Coimbatore Medical College Hospital, Post graduate. and Assistant Professor.
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

We report a 42 year old male who was an interesting case of idiopathic CD4 lymphocytopenia(ICL) in a non-HIV adult with-extra pulmonary tuberculosis along with the diffuse splenic calcification and whose symptoms improved with Antitubercular treatment. He was found to have low CD4 counts on two occasions.


PubMed | Coimbatore Medical College Hospital, Post Graduate. and Assistant Professor.
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

A 38 years old male patient presented to the emergency department with acute severe retrosternal chest pain and was found to have pulmonary thromboembolism. The patient developed new necrotic lung cavities each day due to the dissemination of emboli from the thrombus. The cause of thrombus was found to be protein C deficiency, which is an inherited thrombophilia. The interesting features in this case are multiple lung cavitations and high grade fever, which was attributed to pulmonary thromboembolism. The patient improved symptomatically with anticoagulants and antiplatelets.

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