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Quinto di Treviso, Italy

Gallucci M.,Cognitive Impairment Center | Zanardo A.,General Hospital of Treviso | Bendini M.,Neuroradiology Unit | Di Paola F.,Neuroradiology Unit | And 2 more authors.
Journal of Alzheimer's Disease

Background: The role of folate and homocysteine in brain atrophy associated with Alzheimer's disease is not completely understood. Objective: The aim of this study was to investigate the relationships between serum folate and homocysteine levels and the degree of cortical-subcortical and hippocampal atrophy in a first relatively preliminary sample of the Treviso Dementia (TREDEM) study using a potent data mining method. Methods: Physiological data, biochemical parameters, clinical assessment data, brain atrophy severity assessed with CT scans, and neuropsycological and disability data were assessed in a group of 232 outpatients (93 men and 139 women, aged 40.2-100 years) enrolled in the TREDEM study carried out in Treviso (Italy). A semantic connectivity map obtained through the Auto-CM system, a fourth generation artificial neural network (ANN), was used to offer some insight regarding the complex biological connections between the studied variables and the degree of brain atrophy. Results: Close associations between low serum folate levels and severe cortical-subcortical atrophy along with severe hippocampal atrophy measured by the width of the temporal horns of lateral ventricles were found. We also showed an association between high homocysteine levels and severe cortical-subcortical and hippocampal atrophy. Conclusion: The role of folate, which is inversely associated with the severity of brain atrophy, was confirmed. Our results also confirm the association between high homocysteine levels and severe cortical-subcortical and hippocampal atrophy. Auto-CM ANN is able to highlight associations sometimes visible only in longitudinal studies through intelligent data mining of a cross-sectional study. © 2014 - IOS Press and the authors. All rights reserved. Source

Fougere B.,Toulouse 1 University Capitole | Fougere B.,French Institute of Health and Medical Research | Vellas B.,Toulouse 1 University Capitole | Vellas B.,French Institute of Health and Medical Research | And 6 more authors.
Ageing Research Reviews

The rapid growth in the number of older adults has many implications for public health, including the need to better understand the risks posed by environmental exposures. Aging leads to a decline and deterioration of functional properties at the cellular, tissue and organ level. This loss of functional properties yields to a loss of homeostasis and decreased adaptability to internal and external stress. Frailty is a geriatric syndrome characterized by weakness, weight loss, and low activity that is associated with adverse health outcomes. Frailty manifests as an age-related, biological vulnerability to stressors and decreased physiological reserves. Ambient air pollution exposure affects human health, and elderly people appear to be particularly susceptible to its adverse effects.The aim of this paper is to discuss the role of air pollution in the modulation of several biological mechanisms involved in aging. Evidence is presented on how air pollution can modify the bidirectional association between successful and pathological aging throughout the frailty conditions. © 2015 Elsevier B.V. Source

Fougere B.,Toulouse 1 University Capitole | Fougere B.,French Institute of Health and Medical Research | Mazzuco S.,University of Padua | Spagnolo P.,Cognitive Impairment Center | And 7 more authors.
Journal of Nutrition, Health and Aging

Objectives: To determine the association between Mediterranean-Style Dietary Pattern Score and physical performance. Design: Data analysis of a longitudinal study of a representative, age stratified, population sample. Setting: The TREVISO LONGEVA (TRELONG) Study, in Treviso, Italy. Participants: In 2010, 123 men and 181 women, age 77 years and over (mean age 86.3 ± 6.8 years). Measurements: Performing a logistic regression in a multivariate analysis, hand grip strength and Short Physical Performance Battery (SPPB) were tested in relation to Mediterranean-Style Dietary Pattern Score (MSDPS). Results: The hand grip mean value was 10.9 kg (± 9.5) and the SPPB score was 6.3 (± 3.8). The MSDPS mean value in this study sample was 38.1/100 (± 8.1). A significant association (p=0.036) between a high adherence to the Mediterranean diet (fourth quartile) and higher performance lower limbs (SPPB>7) was found. No correlation was reported for the hand grip strength. Conclusion: We found an association statistically significant between a high adherence to the Mediterranean diet and higher physical performance. © 2016, Serdi and Springer-Verlag France. Source

Gallucci M.,Cognitive Impairment Center | Gallucci M.,Interdisciplinary Geriatric Research Foundation | Ongaro F.,University of Padua | Meggiolaro S.,University of Padua | And 13 more authors.
Archives of Gerontology and Geriatrics

Prolongation of life is an important public health goal as long as there is an emphasis on the quality of life (QoL) and independent living. Diminishing abilities to ambulate and participate in activities of daily living point to a serious decline in functional health, increasing the risk of institutionalization and death. In our work we found a pattern of factors associated with disability, especially cognitive impairment, as well as stroke, physical activity and performance, reading, and the nutritional biomarkers, blood albumin and high-density lipoprotein cholesterol (HDL-C). The attention to this cluster of markers, suggesting multidimensional prevention, may have unexpected good effects against disability. © 2010 Elsevier Ireland Ltd. Source

Albani D.,Istituto di Ricerche Farmacologiche Mario Negri | Ateri E.,Istituto di Ricerche Farmacologiche Mario Negri | Mazzuco S.,University of Padua | Ghilardi A.,Istituto di Ricerche Farmacologiche Mario Negri | And 17 more authors.

Human sirtuins are seven proteins with deacetylase activity that are emerging as key modulators of basic physiological functions. Some evidence links SIRT3 to longevity in mammals. This study aimed to investigate whether variants within SIRT3 gene were associated to human longevity. We analyzed 549 genomic DNA collected during the prospective study "Treviso Longeva," including elderly over 70 years of age from the municipality of Treviso, a small city in the northeast of Italy. We genotyped SIRT3 rs3825075, rs4980329, and rs11555236 single nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction allelic discrimination assay. A cross-sectional analysis performed by comparing people over and under 85 years of age did not evidence association among the SIRT3 SNPs and longevity. However, when we performed a longitudinal analysis considering mortality as a dependent variable, we observed an association of SIRT3 rs11555236 and rs4980329 with longevity in the whole population (p values corrected for potential confounders=0.04 and 0.03, respectively). After stratification according to gender, the same SNPs were associated to female longevity only (p values corrected for potential confounders=0.03 and 0.02, respectively). Finally, as rs11555236 was reported to be in linkage disequilibrium with a putative functional enhancer within the SIRT3 gene, we assessed whether rs11555236 genotypes correlated with a different level of SIRT3 protein in peripheral blood mononuclear cells.We found an increased level of SIRT3 in subjects homozygous for the (T) allele. We suggest that SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population. © American Aging Association 2013. Source

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