Salter J.D.,Oyagen Inc. |
Morales G.A.,Cogent |
Smith H.C.,Oyagen Inc. |
Smith H.C.,University of Rochester
Trends in Biochemical Sciences | Year: 2014
HIV-1 viral infectivity factor (Vif) is a viral accessory protein that is required for HIV-1 infection due largely to its role in recruiting antiretroviral factors of the APOBEC3 (apolipoprotein B editing catalytic subunit-like 3) family to an E3 ubiquitin ligase complex for polyubiquitylation and proteasomal degradation. The crystal structure of the (near) full-length Vif protein in complex with Elongin (Elo)B/C, core-binding factor (CBF)β and Cullin (Cul)5 revealed that Vif has a novel structural fold. In our opinion the structural data revealed not only the protein-protein interaction sites that determine Vif stability and interaction with cellular proteins, but also motifs driving Vif homodimerization, which are essential in Vif functionality and HIV-1 infection. Vif-mediated protein-protein interactions are excellent targets for a new class of antiretroviral therapeutics to combat AIDS. © 2014 Elsevier Ltd. Source
Cogent | Date: 2012-03-30
Methods and devices for improved echo cancellation in high noise environments, such as in-car speakerphones and the like, are provided that improve cancellation convergence in a high noise environment and in the presence of double talk. A new update method enables a robust echo canceller to update with reduced concern for the canceller being in a receive state or a double talk state. If a signal generated by a local talker is substantially the same as high noise, in terms of corruption of the echo canceller, the echo canceller converges in a robust manner even with continuous high noise at the input.
Cogent | Date: 2013-03-15
A delivery device for inserting an interbody implant into an intervertebral space in a patient has an elongate tube with a channel and is sized to fit in an intervertebral space. The elongate tube has a proximal portion, a distal portion, a longitudinal axis, and a window with a longitudinal axis. The window is disposed adjacent the distal portion of the elongate tube and the longitudinal axis of the window is offset from the longitudinal axis of the elongate tube. The channel is sized to receive the interbody implant, and also the channel is configured such that the interbody implant is advanced therealong from the proximal region toward the distal region. The interbody implant is deployed into the intervertebral space from the window.
Cogent | Date: 2013-10-02
This invention provides an information system about medicine and biology. The system organizes information about these subjects into a variety of classes and allows navigation through the information by displays that include links to related information. The links, when selected, provide links to other related information, allowing quick access to related information. In certain instances the information is displayed in a graphical representation. Selection of an icon representing an item in the graphical representation produces expert-curated information about the item, or links to it, and expert-curated information related to the item, for example, links to related information.
Cogent | Date: 2013-03-27
A frame structure for a multi-level container handling and storage facility