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Poriel C.,CNRS Chemistry Institute of Rennes | Metivier R.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry | Rault-Berthelot J.,CNRS Chemistry Institute of Rennes | Thirion D.,CNRS Chemistry Institute of Rennes | And 2 more authors.
Chemical Communications | Year: 2011

A unique (2,1-b)-indenofluorenyl core flanked with two spirofluorene units, possessing a high triplet energy value and excellent thermal/morphological stability, is reported. © 2011 The Royal Society of Chemistry.

Romain M.,CNRS Chemistry Institute of Rennes | Tondelier D.,Ecole Polytechnique - Palaiseau | Vanel J.-C.,Ecole Polytechnique - Palaiseau | Geffroy B.,Ecole Polytechnique - Palaiseau | And 5 more authors.
Angewandte Chemie - International Edition | Year: 2013

Taking pole position: The relative position of the ring bridging has a unique and remarkable effect on the spectroscopic properties of dihydroindeno[1,2-a]/ [2,1-b]fluorenes (see picture). These blue-emitting positional isomers have been successfully used as the emitting layer in organic light-emitting diodes (OLEDs), with performance among the highest reported for dihydroindenofluorene-based OLEDs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Piard J.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry
Journal of Chemical Education | Year: 2014

The solvent influence on the absorption spectra and the kinetics of the back reaction of the 1′,3′-dihydro-1′,3′,3′-trimethyl-6-nitrospiro(2 H-1-benzopyran-2,2′-2H-indole) (6-NO2-BIPS) has been investigated by means of temperature-controlled, UV-visible spectroscopic measurements. The back reaction process was proved to follow first-order kinetics for five different solvents (toluene, THF, acetonitrile, DMSO, and ethanol) at several temperatures. Kinetics parameters (Ea, A, τ, ΔH#, ΔS#, and ΔG#) were extracted from absorbance decay profiles for all solvents, and a simple model based on solvation mechanism was proposed in good agreement with experimental results. Such a photochromic compound also exhibits strong solvatochromism in its merocyanine form. All these experiments were performed to illustrate solvent effects on kinetic processes and optical properties for students with an undergraduate physical chemistry theoretical background. All the experiments described could be performed in a physical chemistry undergraduate laboratory. (Figure Presented). © 2014 American Chemical Society and Division of Chemical Education, Inc.

Xie J.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry | Bogliotti N.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry
Chemical Reviews | Year: 2014

Macrocyclic compounds are of growing interest because of their natural existence, their interesting biological, physicochemical properties, and potential applications in medicine. Various natural as well as non-natural macrocycles have been synthesized, and synthetic methodologies aiming to access macrocycles containing or derived from carbohydrates have blossomed over the last decades. Such macrocycles, naturally present in a number of biologically active products from plant and microorganism, have attracted great interest due to their structural complexity and the synthetic challenges associated with their total synthesis. More recently, an increasing number of studies have been devoted to the preparation of structurally simpler unnatural structures for biological, chemical, or analytical applications.

He X.-P.,East China University of Science and Technology | He X.-P.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry | Xie J.,CNRS Supramolecular and Macromolecular Photophysics and Photochemistry | Tang Y.,East China University of Science and Technology | And 2 more authors.
Current Medicinal Chemistry | Year: 2012

Protein tyrosine phosphatases (PTPs) are crucial regulators for numerous biological processes in nature. The dysfunction and overexpression of many PTP members have been demonstrated to cause fatal human diseases such as cancers, diabetes, obesity, neurodegenerative diseases and autoimmune disorders. In the past decade, considerable efforts have been devoted to the production of PTPs inhibitors by both academia and the pharmaceutical industry. However, there are only limited drug candidates in clinical trials and no commercial drugs have been approved, implying that further efficient discovery of novel chemical entities competent for inhibition of the specific PTP target in vivo remains yet a challenge. In light of the click-chemistry paradigm which advocates the utilization of concise and selective carbon-heteroatom ligation reactions for the modular construction of useful compound libraries, the Cu(I)-catalyzed azidealkyne 1,3-dipolar cycloaddition reaction (CuAAC) has fueled enormous energy into the modern drug discovery. Recently, this ingenious chemical ligation tool has also revealed efficacious and expeditious in establishing large combinatorial libraries for the acquisition of novel PTPs inhibitors with promising pharmacological profiles. We thus offer here a comprehensive review highlighting the development of PTPs inhibitors accelerated by the CuAAC click chemistry. © 2012 Bentham Science Publishers.

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