CNRS Pascal Institute

Aubiere, France

CNRS Pascal Institute

Aubiere, France
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Barthas F.,CNRS Pascal Institute | Barthas F.,University of Strasbourg | Sellmeijer J.,CNRS Pascal Institute | Sellmeijer J.,University of Strasbourg | And 4 more authors.
Biological Psychiatry | Year: 2015

Background: Besides chronic stress, chronic pain is a prevalent determinant for depression. Changes induced in specific brain regions by sustained pain may alter the processing of affective information, thus resulting in anxiodepressive disorders. Here, we compared the role of the anterior cingulate cortex (ACC) and the posterior insular cortex in the anxiodepressive, sensory, and affective aspects of chronic pain. Methods: Neuropathic pain was induced by cuffing the right sciatic nerve of C57BL/6J mice. Lesions were performed by local injection of ibotenic acid and chronic activation of the ACC by optogenetic stimulation. Anxiodepressive-related behaviors were evaluated through the novelty suppressed feeding, marble burying, splash, and forced swimming tests. Mechanical thresholds were determined using von Frey filaments, and the relief of spontaneous pain was determined by using place conditioning. Results: The ACC lesion prevented the anxiodepressive consequences of chronic pain without affecting the sensory mechanical allodynia. Conversely, the tonic or spontaneous pain and the anxiodepressive consequences of pain remained present after posterior insular cortex lesion, even though the mechanical allodynia was suppressed. Furthermore, optogenetic stimulation of the ACC was sufficient to induce anxiety and depressive-like behaviors in naïve animals. Conclusions: Our results show that, at cortical level, the sensory component of chronic pain remains functionally segregated from its affective and anxiodepressive components. Spontaneous tonic pain and evoked allodynia can be experimentally dissociated. Furthermore, the ACC appears as a critical hub for mood disorders, including for the anxiodepressive consequences of chronic pain, and thus constitutes an important target for divulging the underlying mechanism. © 2015 Society of Biological Psychiatry.


Mendoza J.,CNRS Pascal Institute
Pharmacology Biochemistry and Behavior | Year: 2017

The main circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), however, central timing mechanisms are also present in other brain structures beyond the SCN. The lateral habenula (LHb), known for its important role in the regulation of the monoaminergic system, contains such a circadian clock whose molecular and cellular mechanisms as well as functional role are not well known. However, since monoaminergic systems show circadian activity, it is possible that the LHb-clock's role is to modulate the rhythmic activity of the dopamine, serotonin and norephinephrine systems, and associated behaviors. Moreover, the LHb is involved in different pathological states such as depression, addiction and schizophrenia, states in which sleep and circadian alterations have been reported. Thus, perturbations of circadian activity in the LHb might, in part, be a cause of these rhythmic alterations in psychiatric ailments. In this review the current state of the LHb clock and its possible implications in the control of monoaminergic systems rhythms, motivated behaviors (e.g., feeding, drug intake) and depression (with circadian disruptions and altered motivation) will be discussed. © 2017 Elsevier Inc.


Lhuillier M.,CNRS Pascal Institute
Journal of Mathematical Imaging and Vision | Year: 2017

Recently, methods have been proposed to reconstruct a 2-manifold surface from a sparse cloud of points estimated from an image sequence. Once a 3D Delaunay triangulation is computed from the points, the surface is searched by growing a set of tetrahedra whose boundary is maintained 2-manifold. Shelling is a step that adds one tetrahedron at once to the growing set. This paper surveys properties that helps to understand the shelling performances: shelling provides most tetrahedra enclosed by the final surface, but it can “get stuck” or block in unexpected cases. © 2017 Springer Science+Business Media New York


Fouque C.,CNRS Pascal Institute | Bonnifait P.,Compiègne University of Technology
IEEE Transactions on Intelligent Transportation Systems | Year: 2012

Map matching means determining the location of a mobile with respect to a road network description stored in a digital map. This problem is usually addressed using Global Positioning System (GPS)-like fixes. Unfortunately, there are many situations in urban areas where few satellites are visible because of outages due to tall buildings. In this paper, map matching is solved using raw GPS measurements (pseudoranges and Doppler measurements), avoiding the necessity to compute a global position. The problem is formalized in a general Bayesian framework to handle noise, which can perform multihypothesis map matching when there is not enough information to make unambiguous decisions. This tightly coupled GPS-map fusion has to simultaneously cope with identifying the road and estimating the mobile's position on that road. A marginalized particle filter is proposed to efficiently solve this hybrid estimation problem. Real experimental results are reported to show that this approach can be initialized with fewer than four satellites. It can also track the location with only two satellites once the road selection has been solved. © 2011 IEEE.


Lhuillier M.,CNRS Pascal Institute
International Journal of Computer Vision | Year: 2011

Recently, it was suggested that structure-from-motion be solved using generic tools which are exploitable for any kind of camera. The same challenge applies for the automatic reconstruction of 3D models from image sequences, which includes structure-from-motion. This article is a new step in this direction. First, a generic error model is introduced for central cameras. Second, this error model is systematically used in the 3D modeling process. The experiments are carried out in a context which has rarely been addressed until now: the automatic 3D modeling of scenes using a catadioptric camera. © 2010 Springer Science+Business Media, LLC.


Nalitov A.V.,CNRS Pascal Institute | Solnyshkov D.D.,CNRS Pascal Institute | Malpuech G.,CNRS Pascal Institute
Physical Review Letters | Year: 2015

We demonstrate that honeycomb arrays of microcavity pillars behave as an optical-frequency two-dimensional photonic topological insulator. We show that the interplay between the photonic spin-orbit coupling natively present in this system and the Zeeman splitting of exciton polaritons in external magnetic fields leads to the opening of a nontrivial gap characterized by a C=±2 set of band Chern numbers and to the formation of topologically protected one-way edge states. © 2015 American Physical Society.


Lhuillier M.,CNRS Pascal Institute
IEEE Transactions on Pattern Analysis and Machine Intelligence | Year: 2012

Two problems occur when bundle adjustment (BA) is applied on long image sequences: large calculation time and drift (or error accumulation). In recent work, the calculation time is reduced by local BAs applied in an incremental scheme. The drift may be reduced by fusion of GPS and Structure-from-Motion. An existing fusion method is BA minimizing a weighted sum of image and GPS errors. This paper introduces two constrained BAs for fusion which enforce an upper bound for the reprojection error. These BAs are alternatives to the existing fusion BA which does not guarantee a small reprojection error and requires a weight as input. Then, the three fusion BAs are integrated in an incremental Structure-from-Motion method based on local BA. Last, we will compare the fusion results on long monocular image sequences and low cost GPS. © 2012 IEEE.


Review publications show the advantages of using quantum Monte Carlo (QMC) methods when bonding interactions are modified and consequently, where the electron correlation energy varies and needs to be evaluated accurately. This article considers a model efficient metal catalyst for reactions of carbon monoxide. The ultimate aim is to help design industrially useful catalysts, since the reaction with water produces hydrogen gas selectively, that is, a clean fuel and a sustainable energy source. To narrow the gap between the industrial process and calculation, a model of platinum/oxide is studied. It is mimicked here by copper with and without adsorbed oxygen. Periodicity as well as a validated pseudo-potential are used to limit the number of active electrons considered. A suitable code to carry out this task is CASINO. Furthermore, this code scales linearly to 100,000 processors and possesses a shared memory facility so that it is well-suited to runs on the Blugene/P. It has been in production on such computers since early in 2011. A mixed plane-wave/exponential type orbitals (ETO) basis is used for the systems studied. Plane waves are well-suited to periodic solid substrates and a linear combination of ETOs for molecules. The atomic orbitals have direct physical interpretation, i.e., Coulomb Sturmians and hydrogen-like orbitals. Their radial nodes are shown to be essential in obtaining the vitally important accurate QMC trial wave-functions. Until 2008, ETO products on different atoms were difficult to manipulate for the evaluation of two-electron integrals. Coulomb resolutions provide an excellent approximation that reduces these integrals to a sum of one-electron overlap-like integral products that each involve orbitals on at most two centers. They are thus readily evaluated. Only these integrals need to be re-evaluated to change basis functions. In this article, QMC-VMC variational optimisation is used with a quasi analytic two-electron and nucleus correlation factor. The QMC diffusion Monte Carlo methodology is applied to adsorbed carbon monoxide and some of its reactions. © 2011 Wiley Periodicals, Inc.


Granet G.,CNRS Pascal Institute
Journal of the Optical Society of America A: Optics and Image Science, and Vision | Year: 2012

Both of them divide the computational domain into nonoverlapping subdomains and replace the spatial derivative in the Helmoltz equation by a differentiation matrix at the Chebyshev collocation points. The authors of the second reference claim that their method is more robust and accurate because they match the Fourier coefficient at the interfaces between the layers and drop some computed eigenmodes. We challenge these two ideas. Instead, we numerically demonstrate that by keeping all computed eigenmodes and by also numerically computing eigenmodes in homogeneous regions, the pseudospectral method performs better. © 2012 Optical Society of America.


Granet G.,CNRS Pascal Institute
Journal of the Optical Society of America A: Optics and Image Science, and Vision | Year: 2014

The B-spline modal method (BMM) as applied to lamellar gratings analysis is revisited, and a new implementation is presented. The main difference with our previous work is that we now take into account discontinuities by putting a spline with a degenerate knot on them. Our new approach is compared with other implementations of the BMM and is shown to be superior in terms of numerical convergence. © 2014 Optical Society of America.

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