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Biot C.,CNRS Laboratory of Catalysis and Solid State Chemistry | Biot C.,Lille University of Science and Technology | Dive D.,University of Lille Nord de France
Topics in Organometallic Chemistry | Year: 2010

This chapter summarizes recent developments in the design, synthesis, and structure-activity relationship studies of organometallic antimalarials. It begins with a general introduction to malaria and the biology of the parasite Plasmodium falciparum, with a focus on the heme detoxification system. Then, a number of metal complexes from the literature are reported for their antiplasmodial activity. The second half of the chapter deals with the serendipitous discovery of ferroquine, its mechanism(s) of action, and the failure to induce a resistance. Last, but not least, we suggest that the bioorganometallic approach offers the potential for the design of novel therapeutic agents. © 2010 Springer-Verlag Berlin Heidelberg. Source


Ghelamallah M.,University of Mascara | Granger P.,CNRS Laboratory of Catalysis and Solid State Chemistry
Fuel | Year: 2012

The dry reforming of CH 4 by CO 2 has been studied, between 300 and 900°C, over monometallic platinum and rhodium based catalysts supported on α-Al 2O 3 doped with La 2O 3 and BaO. Those catalysts were prepared by conventional wet impregnation and characterized by various physicochemical techniques (nitrogen adsorption, X-ray diffraction, XPS analysis and H 2- temperature-programmed experiments). It was found that Pt and Rh incorporation leads to different types of interactions with La and Ba-modified α-Al 2O 3. As observed, Pt would preferentially interact with Ba inducing an inhibiting effect on the rate of the CH 4/CO 2 reaction reflected by a significant increase in the apparent activation energy. On the other hand, the preferential interaction of Rh with lanthanum oxide after Ba incorporation leads to the preservation of the catalyst activity. Such changes in catalytic properties have been discussed in the light of surface characterization and previous mechanistic information related to the occurrence of a bi-functional mechanism involving the metal/support interface. © 2012 Elsevier Ltd. All rights reserved. Source


Bonin H.,CNRS Laboratory of Catalysis and Solid State Chemistry | Fouquet E.,CNRS Institute of Molecular Sciences | Felpin F.-X.,CNRS Institute of Molecular Sciences | Felpin F.-X.,University of Nantes
Advanced Synthesis and Catalysis | Year: 2011

This review gives an overview of the use of unusual diazonium and iodonium salts as electrophiles for the Suzuki-Miyaura reaction. The discussion mainly focuses, with a critical view, on catalytic systems developed with these electrophiles. The review also discusses their general properties and preparation as well as mechanistic aspects. A last and brief comparison of diazonium versus iodonium salts, by highlighting advantages and drawbacks of both, gives the reader an understandable resumé. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Granger P.,CNRS Laboratory of Catalysis and Solid State Chemistry | Parvulescu V.I.,University of Bucharest
Chemical Reviews | Year: 2011

Important results reported on three-way and lean-burn DeNOx catalysts, demonstrating the added value of surface science and molecular modeling investigations, are reviewed. DeNOx systems are found to enable much lower fuel consumption level and for this the NOx control would be more probably centered on further improvement of the selective catalytic reduction performances. The emissions of N2O are not actually regulated in Europe but might be considered in the future. This implies development of intrinsically active and selective catalytic systems to lower outlet NO emission and also to reduce the steric hindrance of end-of-pipe systems. Recent work demonstrates that Cu:SAPO-5 and Cu:SAPO-11 synthesized using hydrothermal ion exchange method led to a 6-fold increased Cu incorporation and to an increased stability of copper as bidentate Cu species that might represent a significant breakthrough compared to previous attempts. Source


Bonin H.,CNRS Laboratory of Catalysis and Solid State Chemistry | Sauthier M.,CNRS Laboratory of Catalysis and Solid State Chemistry | Felpin F.-X.,University of Nantes
Advanced Synthesis and Catalysis | Year: 2014

This review gives an overview of the generation of aryl radicals, mediated by transition metals, and their use for the C-H arylation of heteroarenes. The different sources of aromatic derivatives able to generate aryl radicals via a metal-assisted reduction or oxidation are discussed, with a critical view of the developed systems. The radical arylations of nitrogen-, oxygen- or sulfur-containing heterocycles are then described and mechanistic considerations are discussed as well. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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