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Kleinschmidt J.H.,The Interdisciplinary Center | Popot J.-L.,CNRS Molecular Chemistry Laboratory
Archives of Biochemistry and Biophysics | Year: 2014

Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have proven remarkably efficient at (i) stabilizing TMPs, as compared to detergent solutions, and (ii) folding them from a denatured state to a native, functional one. The underlying physical-chemical mechanisms are discussed. © 2014 Elsevier Inc. All rights reserved. Source


Iehl J.,CNRS Molecular Chemistry Laboratory | Nierengarten J.-F.,CNRS Molecular Chemistry Laboratory | Harriman A.,Northumbria University | Bura T.,CNRS The Institute of Chemistry and Processes for Energy, Environment and Health | Ziessel R.,CNRS The Institute of Chemistry and Processes for Energy, Environment and Health
Journal of the American Chemical Society | Year: 2012

A sophisticated model of the natural light-harvesting antenna has been devised by decorating a C 60 hexa-adduct with ten yellow and two blue boron dipyrromethene (Bodipy) dyes in such a way that the dyes retain their individuality and assist solubility of the fullerene. Unusually, the fullerene core is a poor electron acceptor and does not enter into light-induced electron-transfer reactions with the appended dyes, but ineffective electronic energy transfer from the excited-state dye to the C 60 residue competes with fluorescence from the yellow dye. Intraparticle electronic energy transfer from yellow to blue dyes can be followed by steady-state and time-resolved fluorescence spectroscopy and by excitation spectra for isolated C 60 nanoparticles dissolved in dioxane at 293 K and at 77 K. The decorated particles can be loaded into polymer films by spin coating from solution. In the dried film, efficient energy transfer occurs such that photons absorbed by the yellow dye are emitted by the blue dye. Films can also be prepared to contain C 60 nanoparticles loaded with the yellow Bodipy dye but lacking the blue dye and, under these circumstances, electronic energy migration occurs between yellow dyes appended to the same nanoparticle and, at higher loading, to dye molecules on nearby particles. Doping these latter polymer films with the mixed-dye nanoparticle coalesces these multifarious processes in a single system. Thus, long-range energy migration occurs among yellow dyes attached to different particles before trapping at a blue dye. In this respect, the film resembles the natural photosynthetic light-harvesting complexes, albeit at much reduced efficacy. The decorated nanoparticles sensitize amorphous silicon photocells. © 2011 American Chemical Society. Source


Nierengarten I.,CNRS Molecular Chemistry Laboratory | Nierengarten J.-F.,CNRS Molecular Chemistry Laboratory
Chemistry - An Asian Journal | Year: 2014

Among the large variety of bioactive C60 derivatives, fullerene derivatives substituted with sugar residues, that is, glycofullerenes, are of particular interest. The sugar residues are not only solubilizing groups; their intrinsic biological properties also provide additional appealing features to the conjugates. The most recent advances in the synthesis and the biological applications of glycofullerenes are summarized in the present review article with special emphasis on globular glycofullerenes, that is, fullerene sugar balls, constructed on a hexa-substituted fullerene scaffold. The high local concentration of carbohydrates around the C60 core in fullerene sugar balls is perfectly suited to the binding of lectins through the "glycoside cluster effect", and these compounds are potential anti-adhesive agents against bacterial infection. Moreover, mannosylated fullerene sugar balls have shown antiviral activity in an Ebola pseudotyped infection model. Finally, when substituted with peripheral iminosugars, dramatic multivalent effects have been observed for glycosidase inhibition. These unexpected observations have been rationalized by the interplay of interactions involving the catalytic site of the enzyme and non-glycone binding sites with lectin-like abilities. Sweet 60s: The most recent advances in the synthesis and biological applications of glycofullerenes are summarized in the present review article, with special emphasis on globular glycofullerenes, that is, fullerene sugar balls, constructed on a hexa-substituted fullerene scaffold. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Compain P.,CNRS Molecular Chemistry Laboratory | Compain P.,Institut Universitaire de France | Bodlenner A.,CNRS Molecular Chemistry Laboratory
ChemBioChem | Year: 2014

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly emerging area with exciting potential and scope. This review presents a description of the different types of neoglycoclusters and their evaluation as glycosidase inhibitors. The first promising therapeutic applications are discussed, as well as the mechanisms underlying the observed inhibitory multivalent effect. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Nierengarten I.,CNRS Molecular Chemistry Laboratory | Nierengarten J.-F.,CNRS Molecular Chemistry Laboratory
Chemical Record | Year: 2015

Click reactions largely cross the borders of organic synthetic chemistry and are now at the forefront of many interdisciplinary studies at the interfaces between chemistry, physics, and biology. As part of this research, our group is involved in a program on the development of clickable fullerene building blocks and their application in the preparation of a large variety of new advanced materials and bioactive compounds. Importantly, the introduction of the click chemistry concept in fullerene chemistry allowed us to produce compounds that would barely be accessible by using the classical tools of fullerene chemistry. This is particularly the case for the conjugation of fullerenes with other carbon nanoforms, such as carbon nanohorns and graphene. It is also the case for most of the sophisticated molecular ensembles constructed from clickable fullerene hexa-adduct building blocks. In this paper, we have summarized our ongoing progress in this particular field. © 2014 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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