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Smail-Faugeron V.,French Institute of Health and Medical Research | Smail-Faugeron V.,CNRS Biometrics Innovations and Interfaces | Fron-Chabouis H.,CNRS Biometrics Innovations and Interfaces | Durieux P.,French Institute of Health and Medical Research | And 2 more authors.
Journal of Dental Research | Year: 2015

Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials. © International & American Associations for Dental Research.


Muller-Bolla M.,University of Nice Sophia Antipolis | Muller-Bolla M.,CNRS Biometrics Innovations and Interfaces | Lupi-Pegurier L.,University of Nice Sophia Antipolis | Bardakjian H.,McGill University | And 3 more authors.
Community Dentistry and Oral Epidemiology | Year: 2013

Objectives A split-mouth randomized clinical trial was carried out to assess the effectiveness of a school-based dental sealant (SBDS) program for French children from low-income backgrounds. The secondary objectives were to determine the effectiveness of the program according to the baseline individual caries risk (ICR) and to assess the sealant retention. Methods The study included 276 pupils from Nice. The sealing was performed in the first or second grades. The permanent first molars were randomized into two groups: one received resin-based sealant and the other no treatment. Active caries on permanent and temporary teeth, visible plaque, Streptococcus mutans (SM) and Lactobacillus counts were recorded at baseline to assess ICR. An intent-to-treat analysis was performed based on the occurrence of new caries at 1 year of follow-up (study outcome). Univariate and multivariable conditional tooth-matched logistic regression analyses (Proc phreg; SAS) were used to assess the effectiveness of the SBDS program. Results At 1 year of follow-up, 253 children (421 pairs) remained in the analysis. In the adjusted analysis, first permanent molars that received sealants were less at risk of developing new caries at 1 year of follow-up compared with those from the control group (OR = 0.26, 95% CI: 0.14-0.49). Independently of the treatment, SM count, and all other covariates, only the variable 'active caries at baseline' remained related to new caries on first molars at 1 year (OR = 3.11, 95% CI: 1.27-7.62). The effect of the sealants was significant only when the analyses included subjects with active caries (OR = 0.25; 95% CI: 0.12-0.50) or with a high SM count (>10 5, OR = 0.20; 95% CI: 0.10-0.41) at baseline. At the 1-year follow-up, total retention was recorded in 52.7% (n = 222) of the treated teeth. Conclusion The 1-year effectiveness of the SBDS program was demonstrated in low socio-economic areas. Selection of schoolchildren according to individual caries risk factors should be considered in a SBDS program. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Smail-Faugeron V.,French Institute of Health and Medical Research | Smail-Faugeron V.,CNRS Biometrics Innovations and Interfaces | Fron-Chabouis H.,CNRS Biometrics Innovations and Interfaces | Courson F.,Assistance Publique Hopitaux de Paris | Courson F.,CNRS Biometrics Innovations and Interfaces
BMC Oral Health | Year: 2014

Background: To ensure evidence-based decision-making in pediatric oral health, Cochrane systematic reviews that address topics pertinent to this field are necessary. We aimed to identify all systematic reviews of paediatric dentistry and oral health by the Cochrane Oral Health Group (COHG), summarize their characteristics and assess their methodological quality. Our second objective was to assess implications for practice in the review conclusions and provide an overview of clinical implications about the usefulness of paediatric oral health interventions in practice. Methods: We conducted a methodological survey including all paediatric dentistry reviews from the COHG. We extracted data on characteristics of included reviews, then assessed the methodological quality using a validated 11-item quality assessment tool (AMSTAR). Finally, we coded each review to indicate whether its authors concluded that an intervention should be implemented in practice, was not supported or was refuted by the evidence, or should be used only in research (inconclusive evidence).Results: We selected 37 reviews; most concerned the prevention of caries. The methodological quality was high, except for the assessment of reporting bias. In 7 reviews (19%), the research showed that benefits outweighed harms; in 1, the experimental intervention was found ineffective; and in 29 (78%), evidence was insufficient to assess benefits and harms. In the 7 reviews, topical fluoride treatments (with toothpaste, gel or varnish) were found effective for permanent and deciduous teeth in children and adolescents, and sealants for occlusal tooth surfaces of permanent molars. Conclusions: Cochrane reviews of paediatric dentistry were of high quality. They provided strong evidence that topical fluoride treatments and sealants are effective for children and adolescents and thus should be implemented in practice. However, a substantial number of reviews yielded inconclusive evidence. © 2014 Smaïl-Faugeron et al.; licensee BioMed Central Ltd.


Wulfman C.,CNRS Biometrics Innovations and Interfaces | Sadoun M.,CNRS Biometrics Innovations and Interfaces | Lamy De La Chapelle M.,University of Paris 13
IRBM | Year: 2010

The mechanical properties, the biocompatibility and the aesthetic aspect make of zirconia a material of interest for orthopaedics and dental prosthetics. This ceramic presents a transformation of phase ability, which is responsible for its high mechanical resistance and fracture toughness. In biomedical applications, tetragonal metastable zirconia is used. Under mechanical stresses, zirconia grains experience a transformation towards a monoclinic structure. This phenomenon exists also under hydrothermal stresses and is known as low temperature degradation, it is well described for yttria partially stabilised zirconia, 3Y-TZP. Kinetics of transformation is usually studied using X-ray diffraction or AFM. The aim of this article is to present Raman spectroscopy as an alternative and non-destructive method to study the transformation of zirconia. After a presentation of Raman scattering, examples of tetragonal, cubic and monoclinic zirconia Raman spectra are presented. The calibration procedure to assess the penetration of the laser probe in the material is detailed and found to reach 70 μm. The quantitative measurement of monoclinic zirconia volume is explained. An example illustrates the decrease of the transformation from 12 at the material subsurface to 2% in a 70 μm depth. © 2010 Elsevier Masson SAS.


Smail-Faugeron V.,French Institute of Health and Medical Research | Smail-Faugeron V.,CNRS Biometrics Innovations and Interfaces | Fron-Chabouis H.,CNRS Biometrics Innovations and Interfaces | Courson F.,Assistance Publique Hopitaux de Paris | And 4 more authors.
BMC Medical Research Methodology | Year: 2014

Background: Split-mouth randomized controlled trials (RCTs) are popular in oral health research. Meta-analyses frequently include trials of both split-mouth and parallel-arm designs to derive combined intervention effects. However, carry-over effects may induce bias in split- mouth RCTs. We aimed to assess whether intervention effect estimates differ between split- mouth and parallel-arm RCTs investigating the same questions. Methods. We performed a meta-epidemiological study. We systematically reviewed meta- analyses including both split-mouth and parallel-arm RCTs with binary or continuous outcomes published up to February 2013. Two independent authors selected studies and extracted data. We used a two-step approach to quantify the differences between split-mouth and parallel-arm RCTs: for each meta-analysis. First, we derived ratios of odds ratios (ROR) for dichotomous data and differences in standardized mean differences (SMD) for continuous data; second, we pooled RORs or SMDs across meta-analyses by random-effects meta-analysis models. Results: We selected 18 systematic reviews, for 15 meta-analyses with binary outcomes (28 split-mouth and 28 parallel-arm RCTs) and 19 meta-analyses with continuous outcomes (28 split-mouth and 28 parallel-arm RCTs). Effect estimates did not differ between split-mouth and parallel-arm RCTs (mean ROR, 0.96, 95% confidence interval 0.52-1.80; mean SMD, 0.08, -0.14-0.30). Conclusions: Our study did not provide sufficient evidence for a difference in intervention effect estimates derived from split-mouth and parallel-arm RCTs. Authors should consider including split-mouth RCTs in their meta-analyses with suitable and appropriate analysis. © 2014 Smaïl-Faugeron et al.; licensee BioMed Central Ltd.


Behin P.,Lille 2 University of Health and Law | Stoclet G.,CNRS Materials and Transformations Unit of UMET | Ruse N.D.,University of British Columbia | Sadoun M.,CNRS Biometrics Innovations and Interfaces
Dental Materials | Year: 2014

Objectives The aim of this study was to compare the viscoelastic properties of high pressure (HP) polymerized urethane dimethacrylate (UDMA) with those of control, ambient pressure thermo-polymerized and photo-polymerized, UDMA and to assess the effect of varying polymerization parameters (protocol, temperature, and initiator) on the viscoelastic properties of HP polymerized UDMA. Methods The viscoelastic properties of the two control polymers, polymerized under atmospheric pressure, and four experimental polymers, polymerized under HP, were determined via dynamic mechanical analysis (DMA), in three point bending configuration. Atomic force microscopy (AFM) was used to characterize fractured polymer surface morphologies. Results The results showed that: HP-polymerization lead to a polymer with significantly higher Tg and E′rub, indicative of a higher crosslink density; modifying the polymerization protocol resulted in a significant increase in tan δ; increasing the polymerization temperature lead to a significant decrease in E′rub and Tg; and that the polymer with no initiator had the lowest E′, E″, Tg, and E′rub and the highest tan δ, suggesting that under this conditions a polymer with significantly reduced crosslink density had been obtained. A characteristic nodular appearance was seen for the two control polymers under AFM, while a modified surface morphology was present in the case of HP polymerized materials. Significance The DMA results suggest that polymerization under HP resulted in polymers with an increased crosslink density and that the higher polymerization temperature or the lack of initiator was detrimental to the viscoelastic properties determined. Changes in polymer network morphology were identified by AFM characterization. © 2014 Academy of Dental Materials.


PubMed | University of British Columbia, Lille University of Science and Technology, CNRS Biometrics Innovations and Interfaces, Lille 2 University of Health and Law and University Paris Diderot
Type: Journal Article | Journal: Dental materials : official publication of the Academy of Dental Materials | Year: 2015

The aim of this study, part of our research to improve properties of resin composite blocks suitable for CAD/CAM and to better understand underlying mechanisms associated with high-temperature/high-pressure (HT/HP) polymerization, was to determine an optimum polymerization pressure of urethane dimethacrylate (UDMA) in the presence of an initiator (0.5% benzoyl peroxide) by determining the degree of conversion (DC) and viscoelastic properties of polymers obtained at 90C under varying HP.DC and viscoelastic properties of 16 UDMA polymers, two controls (thermo-cured and thermo-cured followed by post-cure relaxation) and 14 experimental groups (HP polymers, in the range of 50-350 MPa, in 50 MPa increments, without and with post-cure relaxation) were determined via near infrared spectroscopic analysis and dynamic mechanical analysis, respectively.The results have shown that HP UDMA polymers have DC superior to that of the control group. With regards to E and E, the results have shown no significant difference between control and HP polymers. The damping factor, tan, decreased with increasing pressure, while Erub and Tg increased. Polymerization at 150 MPa or higher resulted in significantly higher Erub and Tg.The results of this study suggested that HP polymerization at 90C of UDMA reduced the number of defects and the free volume, leading to a more homogeneous polymer network. The results have also suggested that 200 MPa is an optimum polymerization pressure, resulting in polymers with significantly higher DC, Erub, and Tg, while maintaining adequate damping capacity (tan).


PubMed | University of Nice Sophia Antipolis and CNRS Biometrics Innovations and Interfaces
Type: | Journal: BMC oral health | Year: 2015

Since the 2000s, different epidemiological studies focusing on the prevalence or the aetiology of DE in adolescents recognised them as an at-risk population due to their eating behaviours. None was carried out in French adolescents. The primary objective of this study was to assess the prevalence of dental erosion (DE) using the total BEWE score among adolescents in the department of Alpes Maritimes, France. The secondary objectives were to observe changes in prevalence estimates depending on both the cutoffvalue of total BEWE score with different teeth/dental surfaces examined, and to identify the related risk factors.A cross-sectional study in a multistage random sample of 339 14-yr-old schoolchildren was carried out in 2014. The children completed a self-administered questionnaire concerning diet and oral habits. Caries was assessed with ICDAS-II (International Caries Detection and Assessment System-II) criteria and erosion with BEWE (Basic Erosive Wear Examination) index. The total BEWE score was calculated to assess the DE prevalence with two cutoff values (3 and 1). Data were analysed using descriptive statistics and logistic regression models.The 331 children were aged 14.40.5 years. The DE prevalence was 39 % using a total BEWE score3. With a cutoff total BEWE score of 1 (at least one affected tooth), the prevalence varied from 3.9 to 56.8 % depending on the teeth/surfaces that were used for the analysis. The DE prevalence, assessed with only first molars and maxillary incisors, was about 54 %. The risk factors for DE (total BEWE score3) were daily consumption of acidic beverages (OR: 4.0; 95 % CI: 2.1-7.6) and acidic sweets (OR: 3.2; 95 % CI: 1.2-8.0), low socio economic category (OR: 2.4; 95 % CI: 1.1-5.0) and visible dental biofilm (OR: 2.0; 95 % CI: 1.2-3.4).Depending on the method chosen, the prevalence varied from 3.9 to 56.8 % among these adolescents. Thus, a consensus on choice of index, teeth to examine and age at assessment is necessary to standardise measurement of DE prevalence.


PubMed | CNRS Biometrics Innovations and Interfaces and University of Paris Descartes
Type: Journal Article | Journal: Journal of dental research | Year: 2015

Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials.


PubMed | CNRS Biometrics Innovations and Interfaces and Assistance Publique Hopitaux de Paris
Type: | Journal: BMJ case reports | Year: 2016

To assess management of non-syndromic dens evaginatus affecting permanent maxillary central incisor, we performed a systematic review and also present a case report. We searched PubMed via MEDLINE and the reference lists of included reports. Eligible studies were any type of clinical studies describing the management of non-syndromic dens evaginatus affecting the crown of a permanent maxillary central incisor. We included 31 studies corresponding to 34 relevant case reports. Therapeutic options were complete reduction of the talon cusp in a single appointment (56%), periodic and gradual reduction of the cusp (26%), abstention (13%) or extraction (5%). We report an 8-year-old girl with unusual two-talon cusp, labial and lingual, on a right maxillary double central incisor. A multidisciplinary approach is key to management of permanent maxillary central incisors affected by coronary anomalies.

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