Anuj G.,CMJ University
International Journal of Drug Development and Research | Year: 2012
The purpose of present article is to discuss the concept of pharmaceutical Quality by Design (QbD) and describe how it can be help to ensure pharmaceutical quality. Quality by design is an essential part of the modern approach to pharmaceutical quality. The elements of quality by design are examined and a consistent nomenclature for quality by design, critical quality attribute, critical process parameter, critical material attribute, and control strategy is proposed. The use of QbD was contrasted with the evaluation of product quality by testing alone. The QbD is a systemic approach to pharmaceutical development. It means designing and developing formulations and manufacturing processes to ensure predefined product quality. Some of the QbD elements include defining target product quality profile, designing product and manufacturing processes, identifying critical quality attributes, process parameters, and sources of variability & controlling manufacturing processes to produce consistent quality over time. Using QbD, pharmaceutical quality is assured by understanding and controlling formulation and manufacturing variables. © 2012 IJDDR.
Parhi P.K.,CMJ University |
Mohapatra P.,Sudan University of Science and Technology
Der Pharmacia Lettre | Year: 2012
The aim of the present study was designed to evaluate the pharmacognostical and preliminary phytochemical evaluation of the whole plant Spermacoce ocymoides (Burm F.) DC. The pharmacognostical profiles which includes Organoleptic evaluation, micro morphology of leaves and seeds; microscopic evaluation e.g. like Leaf microscopy, Root microscopy, Stem microscopy, determination of leaf constants e.g. determination of stomatal number and stomatal index, determination of vein-islet and vein termination number; Powder microscopy of whole plants along with determination of average length of trichomes of leaf, stems and whole plants, Determination of length and width of fibres of whole plant; Fluorescence analysis and reagent analysis with powder drugs; Physical properties evaluation of powder materials of the whole plant e.g. Extractive values, Ash values e.g. total ash, Water soluble ash, Acid insoluble ash, Sulphated ash; others e.g. Moisture content, PH (1% w/v solution), swelling index, foaming index and the powdered plant materials than subjected to successive extraction process with different solvents with increasing order of their polarity using standard extraction processes like reflux condensation process and Preliminary phyto-chemical screening has been done to find out the nature of phyto-constituents present within them for the further research work.
Rajendra D.,CMJ University |
Roy A.S.,Gulbarga University |
Parveen A.,Government First Grade College
Composites Part B: Engineering | Year: 2013
Polyethylene oxide-NaClO3 composite have been prepared by solution casting technique with different weight percentages as a polymer electrolyte for battery application. The prepared composites were characterized by various tools like XRD, FTIR and SEM. The X-ray diffraction analysis shows the complexation of polymer with salt and existence of both crystalline and amorphous phases. From FTIR spectra confirms the formation of PEO-NaClO 3 composites. SEM images shows the grains are highly agglomerated and its average size increases with increase in salt ratio. Frequency dependence of dielectric property and ac electrical conductivity of polymer electrolytes were studied within the frequency range of 50 Hz to 5 MHz using complex impedance analysis technique. Ionic conductivity follows Arrhenius type behavior as a function of temperature. The fabricated cell of 25 wt.% of PEO-NaClO3 composites generated high current of 1.79 A. © 2013 Elsevier Ltd. All rights reserved.
Thandavamoorthy T.S.,Adhiparasakthi Engineering College |
Saileysh Sivaraja S.,CMJ University
International Journal of Earth Sciences and Engineering | Year: 2013
The paper describes the performance of a series of un-reinforced Rat-trap bond masonry panels, respectively, observed during shock table tests in the laboratory. A large inventory of older masonry buildings exists in earthquake-prone regions. In most cases these buildings contain shear walls constructed of un-reinforced masonry. The majority of these buildings were built before any provisions for earthquake loadings were established. The failures and damages reported in recent earthquakes attest to the need for efficient strengthening procedures. The effectiveness of increasing the shear strength of brick masonry by epoxy-bonding Glass fiber-reinforced polymer (GFRP) overlays to the exterior surfaces was evaluated. Although masonry is one of the oldest construction materials, its behavior has not been investigated as extensively as other construction materials. Out-of-plane failures are common in unreinforced masonry (URM) buildings constructed in seismic regions. It was observed that the total energy imparted to the masonry element size of 2.10 m × 1.10 m × 0.092 m without GFRP was 4785.11 Nm and with GFRP was 10433.99 Nm before its total collapse, which is about 2.18 times greater than that of the case without GFRP strengthening. It is, therefore, concluded here that the behaviour of masonry panel strengthened with GFRP was much better in terms of sustaining more number of impacts, withstanding higher base acceleration, and absorbing more energy. © 2013 CAFET-INNOVA TECHNICAL SOCIETY.
Sundarapandian V.,Vel Tech Dr.RR & Dr.SR Technical University |
Sivaperumal S.,CMJ University
International Journal of Soft Computing | Year: 2011
This study investigates the sliding controller design of hybrid synchronization of Four-Wing Chaotic Systems. In this study, researchers derive new results based on the Sliding Mode Control (SMC) for the hybrid synchronization of identical Qi 3D Four-Wing Chaotic Systems (2008) and identical Liu 3D Four-Wing Chaotic Systems (2009). The stability results for the hybrid synchronization schemes derived in this paper using SMC are established using the Lyapunov Stability theory. Since, the Lyapunov exponents are not required for these calculations, the sliding controller design is very effective and convenient to achieve global hybrid synchronization of the identical Qi Four-Wing Chaotic Systems and the identical Liu Four-Wing Chaotic Systems. Numerical simulations are presented to demonstrate the effectiveness of the synchronization results derived in this study. © Medwell Journals, 2011.
Vaidyanathan S.,Vel Tech Dr.RR & Dr.SR Technical University |
Sampath S.,CMJ University
Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST | Year: 2012
This paper investigates the hybrid synchronization of hyperchaotic Chen systems (Jia, Dai and Hui, 2010) via sliding mode control. The stability results for the sliding mode control based synchronization schemes derived in this paper are established using Lyapunov stability theory. The sliding mode control method is very effective and convenient to achieve global chaos synchronization of the identical hyperchaotic Chen systems because the Lyapunov exponents are not required for these calculations. Numerical simulations are presented to demonstrate the sliding mode control results derived in this paper for the hybrid synchronization of identical hyperchaotic Chen systems. © Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2012.
Vaidyanathan S.,Vel Tech Dr.RR & Dr.SR Technical University |
Sampath S.,Vel Tech Dr.RR & Dr.SR Technical University |
Sampath S.,CMJ University
International Journal of Automation and Computing | Year: 2012
Sliding mode control is an important method used in nonlinear control systems. In robust control systems, the sliding mode control is often adopted due to its inherent advantages of easy realization, fast response and good transient performance as well as its insensitivity to parameter uncertainties and disturbances. In this paper, we derive new results based on the sliding mode control for the anti-synchronization of identical Qi three-dimensional (3D) four-wing chaotic systems (2008) and identical Liu 3D four-wing chaotic systems (2009). The stability results for the anti-synchronization schemes derived in this paper using sliding mode control (SMC) are established using Lyapunov stability theory. Since the Lyapunov exponents are not required for these calculations, the SMC method is very effective and convenient to achieve global chaos anti-synchronization of the identical Qi four-wing chaotic systems and identical Liu four-wing chaotic systems. Numerical simulations are shown to illustrate and validate the synchronization schemes derived in this paper. © 2012 Institute of Automation, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg.
Arya A.,CMJ University |
Singh L.,Rayat And Bahra Institute Of Engg And Biotech
International Journal of Pharma and Bio Sciences | Year: 2013
Chronic diabetes mellitus is associated with various complications such as retinopathy, neuropathy, nephropathy, cardiomyopathy, vasculopathy, dermatopathy and encephalopathy. Nephropathy is one of the major complications of diabetes mellitus, and the morbidity and mortality due to diabetic nephropathy is constantly progressing in industrialized nations. Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its morphologic characteristics include glomerular hypertrophy, basement membrane thickening, mesangial expansion, tubular atrophy, interstitial fibrosis and arteriolar thickening. Numerous reports have demonstrated that oxidative stress induced by diabetes plays an important role in the development and progression of diabetic vascular complications including nephropathy. Biomarkers for oxidative damage to DNA, lipids, and proteins are also supporting the concept of increased oxidative stress in diabetes and diabetic nephropathy. The present review has been undertaken to communicate the pathogenesis of diabetic nephropathy, the role of oxidative stress and reactive oxygen species as well as antioxidant property of Curcumin in ameliorating diabetic nephropathy.
Choudhary G.,CMJ University
Disaster Advances | Year: 2012
Natural Disasters and calamities throw up major challenges for national governments in many countries of the Asia region. Earthquakes, floods, cyclones, epidemics, tsunami and landslides have become of common occurrence in the region, repeatedly taking a heavy toll of life and property.7 Asia experienced in 2009 a largest share as reported in natural disaster occurrence (40.3%), which was accounted for 89.1% ( as per global reported natural disaster victims) and 38.5% as reported in total economic damages ( US$ 41.3 billion).9 After 2009, the extent of the impact of natural disasters took a turn in 2010, which affected over 217.0 million others and caused US$ 123.9 billion of economic damages (Center of Research for Epidemiology of Disasters 2010).2 Economic damages from natural disasters in 2010 were over 2.5 times higher than in 2009 (US$ 47.6 billion) and increased by 25.3% compared to the annual average for the period 2000-2009 (US$ 98.9 billion). Out of total 385 disaster recorded in 2010, twenty two were in China, sixteen were in India and fourteen were in Philippines, (CRED).
Vaidyanathan S.,Tamil University |
Rajagopal K.,CMJ University
International Journal of Soft Computing | Year: 2012
This study investigates the global chaos synchronization of identical hyperchaotic Wang Systems, identical hyperchaotic Pang Systems and non-identical hyperchaotic Wang and hyperchaotic Pang Systems via Adaptive Control Method. Hyperchaotic Pang System and hyperchaotic Wang System are recently discovered hyperchaotic systems. Adaptive Control Method is deployed in this study for the general case when the system parameters are unknown. Sufficient conditions for global chaos synchronization of identical hyperchaotic Pang Systems, identical hyperchaotic Wang Systems and non-identical hyperchaotic Pang and Wang Systems are derived via Adaptive Control Theory andLyapunov Stability Theory. Since, the Lyapunov exponents are not required for these calculations, the Adaptive Control Method is very convenient for the global chaos synchronization of the hyperchaotic systems discussed in this study. Numerical simulations are presented to validate and demonstrate the effectiveness of the proposed synchronization schemes. © Medwell Journals, 2012.