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Patent
CMC Biologics | Date: 2017-02-22

The present invention relates to a high cell density fermentation fill and draw process for producing a product in a bioreactor system wherein during the fermentation, medium comprising impurities is removed via the impurity filter unit while new fresh medium is added to the cell culture vessel to replenish consumed nutrients and expelled medium.


Patent
CMC Biologics | Date: 2015-04-14

The present invention relates to a high cell density fermentation fill and draw process for producing a product in a bioreactor system wherein during the fermentation, medium comprising impurities is removed via the impurity filter unit while new fresh medium is added to the cell culture vessel to replenish consumed nutrients and expelled medium.


The present invention relates to a bioreactor arrangement for producing a biopolymer expressed by a cell and a continuous process for a capturing the biopolymer employing two chromatography units operated in series or independently.


Patent
CMC Biologics | Date: 2015-01-29

The present invention relates to a chromatography system (20) wherein the chromatography system comprises an eluting system (10) and a capturing system (11) consisting of at least two chromatography units (2,3) operated alone or in series and a capturing process employing in-line buffer dilution in, which concentrated buffers are blended with water and provided to the chromatography units.


Patent
CMC Biologics | Date: 2014-03-11

The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1- (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.


Grant
Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.78M | Year: 2011

A group of European SMEs with expertise in process cleaning and cleaning validation as well as other environmental technologies addresses a major market opportunity in the supply of a Process Analytical Technology (PAT) compliant unit for online verification of Clean-in-Place (CIP) processes used in the pharmaceutical industry. CIP equipments provide Water for Injection (WFI) along with cleaning agents at predetermined temperatures and pressures for cleaning production equipments in pharmaceutical or food processing industry. To conform to high level cleaning regulations, preconfigured, longer than necessary cleaning cycles are followed wasting tremendous quantities of water and cleaning agents. Additional laboratory testing of residual samples from the vessels determines whether further cleaning is required or the production process can resume. This results in long periods of process downtime, while the laboratory results are awaited. PATOV is a project designed to significantly optimise these CIP processes by introducing an online, realtime cleaning validation system that will ensure optimal cleaning, but simultaneously control cleaning time and cleaning agents used. This will enable reduction in cleaning costs and process downtime while at the same time providing more analytical information to the client. The critical challenges in the project relate to the continuous sampling and the separation of the liquid component from the returned WFI so that it can be fed into commercially available analysers. Superiorly, the selection and adaptation of a new analytical technology based on infrared spectroscopy seems to be promising. The project is expected to have a severe potential to improve the efficiency and competitiveness of pharmaceutical and food processing industry with significant benefits on the quality of pharmaceutical and food products available to the public. At the same time PATOV will have direct environmental benefits by reducing water and energy consumption by optimizing cleaning cycle time.


Patent
CMC Biologics | Date: 2015-11-25

Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.


Patent
CMC Biologics | Date: 2016-03-07

The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1- (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.


Patent
CMC Biologics | Date: 2014-11-19

Provided is a bioreactor system and a fermentation process employing continuous inline medium dilution in which concentrated medium and nutrients are blended with water or buffer and fed to the cell culture vessel of a bioreactor system, e.g. for production of antibodies and other recombinant proteins by mammalian cells.


A method for improving productivity in microbial fermentations and mammalian cell culture bioreactors.

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