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Adyar, India

Sobana S.,Easwari Engg College | Indumathy M.,Easwari Engg College | Panda R.C.,CLRI
Proceedings of 2015 International Conference on Robotics, Automation, Control and Embedded Systems, RACE 2015 | Year: 2015

In industries it is necessary to monitor and control temperature in real time. Flow dependent temperature control has become vital in different industries like pharmaceuticals, drying, material processing and petroleum industries. This paper aims at nonlinear modeling, identification and control of a temperature-flow cascaded control system. The experimentally obtained open loop models are used to design conventional controllers for primary and secondary loops using Cohen-Coon tuning method. Both flow and temperature processes have also been modeled stochastically and with the help of ANN technique which have been validated with experimental data. The parameters of the model are estimated using Auto Regressive eXogenous (ARX) identification techniques. The conventional PI controller response is compared with Internal Model Control (IMC). Further the Integral Absolute Error (IAE) is computed separately for the conventional controller and the IMC controller to select better performance of controller. In the cascade loop, temperature process is kept in primary loop and flow is considered in the secondary loop. Results indicate that it can be implemented in commercial. Changes in the inlet flow of water to the heating tank affect the temperature of the process fluid directly and hence it is important to control the nonlinear behavior of the flow process in order to control the temperature process. © 2015 Hindustan University.


Hima Bindu T.V.L.,Institute of Pharmaceutical Technology | Vidyavathi M.,Institute of Pharmaceutical Technology | Kavitha K.,Institute of Pharmaceutical Technology | Sastry T.P.,CLRI | Kumar R.V.S.,Veterinary University
Trends in Biomaterials and Artificial Organs | Year: 2010

Natural polymers are used as lead compounds for design of therapeutic drugs in treatment of different ailments. Chitosan and gelatin have proven wound healing properties individually. As both have wound healing property, the combination of two polymers shown improvement in wound healing property. Thus, the composite films were evaluated for various in vitro and invivo tests to ascertain the applicability of prepared combination for wound healing activity. The composite films were prepared with increase in gelatin concentration and were evaluated for thickness, folding endurance, water absorption capacity, tensile strength and for biological properties like antimicrobial activity and in vivo wound healing performance by excision wound model. With increase in gelatin concentration, thickness, folding endurance, water absorption capacity and tensile strength were increased. Percentage of wound contraction was more in wounds treated with chitosan-gelatin composite film. With the above results, it was concluded that chitosan-gelatin combination has improved wound healing property than chitosan film alone.


Khadeer Basha S.,P.A. College | Suresh Kumar R.V.,P.A. College | Haragopal V.,P.A. College | Srilatha C.H.,P.A. College | Sastry T.P.,CLRI
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Dogs with cutaneous wound were selected and randomly divided into two groups, to study the efficacy of fish scales extracted collagen biocasings on cutaneous wound healing. The wounds in both groups of dogs were protected with sterile external bandage after cleaning with normal saline to prevent infection. The efficacy of biocasings on wound healing was studied based on gross, physiological, hematological, biochemical and histological findings at different time intervals of observation. The changes in gross, physiological, biochemical and hematological parameters were due to stress in control group and due to presence of foreign body reaction in biocasings applied group. The histological sequences such as inflammatory reaction, edema, fibroblast proliferation, collagen synthesis, capillary vascularization and re epithelialization were more evident in collagen biocasings applied wounds. Fish scales extracted collagen biocasing did not allow accumulation of wound fluid compared to non applied wounds. Healing time was significantly low in collagen biocasing applied wounds (15.00±0.82 days) compared to untreated group (23.67±0.99 days). The fish scales extracted biocasings were moderately adherent to wound surface but produced good haemostatic effect and resorption was evident in 48 hrs of post application. The biocasings applied wounds gained nearly normal tensile strength at 28th post operative day. The use of fish scales extracted collagen biocasings for cutaneous wound healing in dogs was effective and helped in augmentation of wound healing activity. © 2010 RJPBCS.


Pandurangan M.,Catholic University of Daegu | Pandurangan M.,Catholic University of Korea | Moorthy H.,CLRI | Sambandam R.,Catholic University of Daegu | And 3 more authors.
Cytotechnology | Year: 2014

The present investigation was carried out to evaluate the effect of stress hormone cortisol on the myogenic markers in the C2C12 cells co-cultured with 3T3-L1 preadipocytes. Co-culturing was achieved by transwell inserts with a 0.4 μm porous membrane. C2C12 and 3T3-L1 cells were grown independently on the transwell plates. After differentiation, inserts containing 3T3-L1 cells were transferred to C2C12 plates for co-culturing. 10 μg/μl of cortisol was added to the medium. After 72 h of treatment, C2C12 cells which were in the lower well were harvested for analysis. RT-PCR analysis of myogenic markers such as of myogenin, MyoD, Myf5, PAX3 and PAX7 showed a significant reduction in the mRNA expression of these myogenic markers. In addition, cortisol increased calpain activity, which led to accelerated protein degradation, which in turn reduced the myogenic rate. In conclusion, cortisol treatment reduced mRNA expression of myogenic markers in the co-cultured C2C12 cells, which is quite distinct from one dimensional mono-cultured C2C12 cells. © 2013, Springer Science+Business Media Dordrecht.


Trigunait A.,University of Madras | Malathy P.,University of Madras | Ramachandiran K.,CLRI | Perumal P.T.,CLRI | Gunasekaran K.,University of Madras
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

In the title compound, C25H23BrN2O 4, the seven-membered ring adopts a twisted-boat conformation. The indole ring system is planar within 0.021 (2) Å and the ester group [-C(=O) - O - C-] is almost coplanar with it [dihedral angle = 3.0 (2)°]. The conformation of the ester group is influenced by intra-molecular C - H⋯O inter-actions. In the crystal structure, mol-ecules are linked into chains along the b axis by C - H⋯N hydrogen bonds.

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