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Farber C.M.,Immunodeficiency Treatment Unit | Van Der Biest-Cardinal C.,Cliniques Universitaires Of Bruxelles
Acta Clinica Belgica | Year: 2011

New applications are always being developed for immunoglobulins; new recommendations are regularly published. We wished to know the indications used in a large hospital. A hundred and thirty-six adult patients were prescribed immunoglobulins from January to December 2008. Three preparations in intravenous immunoglobulins were available (one liquid, 2 freeze-dried). Fourteen charts were rejected for clerical errors. A hundred and twenty two charts were available for statistical study. Thirty-six patients were on immunoglobulins for antibody deficiency, 19 were followed in haematology for chronic lymphoid leukaemia or multiple myeloma, 19 were treated after lung transplantation, 17 had received a kidney transplant, 1 after heart transplantation: these indications were substitution. Twenty for Guillain Barré and chronic demyelinating polyneuropathy, 10 in immune thrombocytopenic purpura: this was for immunomodulation. Recommendations were followed by the prescribers; charts were reviewed in March and November 2009. Side-effects were rare. (0.6%) (1). Source


Forfia P.R.,University of Pennsylvania | Vachiry J.-L.,Cliniques Universitaires Of Bruxelles
American Journal of Cardiology | Year: 2012

In the context of pulmonary arterial hypertension (PAH), echocardiographic assessment of right ventricular (RV) function is key to determining disease severity and prognosis. Using Doppler echocardiography (ECHO) there are numerous ways that RV function can be measured, either directly or indirectly, to capture the triad of changes in RV geometry, right-to-left interaction, and RV systolic dysfunction in response to high pulmonary vascular resistance states, such as PAH. To fully evaluate and characterize the nature and extent of the impact of PAH on the RV in an individual patient, it is critical to assess a combination of these direct and indirect measures of RV function. In order to predict changes in status and have prognostic significance, the variables used must be easy to measure, reproducible, and clinically relevant. This review assesses the relative value of different ECHO parameters and looks at what the future holds for ECHO imaging of the right heart in PAH. © 2012 Elsevier Inc. Source


Kingman M.,Southwestern Medical Center | Hinzmann B.,Bayer AG | Vachiery J.-L.,Cliniques Universitaires Of Bruxelles
BMJ Open | Year: 2014

Objectives: To better understand the patient's perspective of pulmonary hypertension (PH), including the impact of living with PH, disease management and treatment. Design: This qualitative ethnographic study collected observational video footage, supplemented by field notes and patient diaries to assess the impact of PH on the patient's life. Setting: Patients were observed and filmed in their home for up to 6 h, capturing the environment, interactions and activities of everyday life. Participants: Patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic PH who were receiving PAH-specific medication were recruited through healthcare professionals (HCPs) and patient associations in seven countries across four continents. Sampling was purposive and subgroup analysis was not intended. Results: Overall, 39 patients with PH were enrolled. Many patients had a poor understanding of PH and found their 'invisible' disease difficult to explain to others. An important finding was the secrecy surrounding PH. Feelings of insecurity and isolation were regularly reported, and many patients admitted to hiding their symptoms. The marked improvement in symptoms after therapy initiation made assessment of disease progression more difficult as patients compared their quality of life (QoL) against pretreatment levels. Extensive planning and adherence to daily routines were required in patients' everyday life. Conclusions: Ethnography was used for the first time, in several countries, to evaluate the patient's perception of living with PH. This approach revealed key findings that would not typically be uncovered using other qualitative techniques, including the secrecy surrounding PH, the difficulties in describing the disease and the challenges in assessing disease progression. A more tailored dissemination of information from HCPs and development of a simple and understandable PH definition may be beneficial in alleviating the secrecy reported by patients. A greater appreciation of how patients perceive their disease and QoL has the potential to improve PH management. Source


Ayadi D.,University of Mons | Etienne P.,University of Mons | Burny F.,University of Mons | Schuind F.,University of Mons | Schuind F.,Cliniques Universitaires Of Bruxelles
Acta Orthopaedica Belgica | Year: 2011

Severe posttraumatic elbow stiffness represents a significant invalidity. Between 1990 and 2005 two surgeons performed open elbow arthrolysis in 30 adult patients (6 women, 24 men, mean age 30.8 years). All cases resulted from severe initial trauma, which had occurred on average 15.5 months previously. Four patients had extrinsic and 18 had mixed contractures ; 13 had heterotopic ossifications. Operative complications included two peroperative joint instabilities and 3 transient nerve palsies. Seven elbows were remobilized under anaesthesia, one month after the arthrolysis. Twenty-two patients could be reviewed, on average 56 months after the arthrolysis. Seventy seven percent of the patients were satisfied. At final follow-up, the average arc of flexion-extension was 95° ± 15° (average flexion 120° ± 13°, average flexion contracture 31° ± 6°), with a mean improvement of 51° relative to the preoperative range (p < 0.001). The average arc of forearm rotation at final follow-up was 151° ± 23°, with a mean improvement of 41° (p < 0.05). No patient suffered persistent weakness or instability. The average VAS was 5/10, the average MEPI score 76, with 6 excellent, 6 good, 6 fair and 4 poor results, mainly because of persisting pain. The average DASH score was 31.6 and the average SF-36 was 66. Significant correlations were observed between VAS and DASH, MEPI and SF-36. This series demonstrates that open arthrolysis may restore acceptable elbow motion in young active patients presenting with elbow stiffness following major trauma. However, full restoration of motion is rare ; only 18% of the patients regained the functional arcs of motion reported by Morrey, but the majority were satisfied, given their preoperative degree of elbow stiffness. The ultimate result from both the patient's and the surgeon's perspectives is strongly dependent on persisting pain, which was frequent in this series and influenced the DASH, MEPI and the SF-36 scores. Arthrolysis did not address the issue, if pain was the chief complaint. © 2011, Acta Orthopædica Belgica. Source


Pepersack T.,Cliniques Universitaires Of Bruxelles | Gilles C.,Center Hospitalier Of Lardenne | Petrovic M.,Universitair Ziekenhuis Gent | Spinnewine A.,Catholic University of Louvain | And 8 more authors.
Acta Clinica Belgica | Year: 2013

Introduction: Orthostatic hypotension (OH) is said to be highly prevalent in older people. Drugs are often involved as causative factor. Nevertheless, few data are available about the prevalence of OH and its relationship with drugs in olders. Objectives: To review data about (i) the prevalence and characteristics of OH in older patients; and (ii) the relationship between OH and drugs. Methods: Review of publications from Ovid (PubMed) from 1980 to May 2011 using the following key words: "orthostatic hypotension" combined with "elderly" or equivalent for the analysis of prevalence (first search) and "orthostatic hypotension" combined with "drugs" or equivalent to assess the relationship between OH and drugs (second search). Results: Fifty-one publications (of which 14 with original data) were retrieved from the prevalence search, 31 for the second search (8 with original data: 7 retrospective studies and 1 prospective cohort study) and 12 reviews or experts opinions. Prevalence of OH varies according to the characteristics of the subjects, the settings of the studies, and the procedures of blood pressure measurement. In acute geriatrics units, two studies reported a prevalence of over 30% and one study mentioned that 68% of the patients presented with at least one episode during the day. OH was associated with several geriatric problems: gait disorders, balance disorders, falls, cerebral hypoperfusion, transient ischemic attacks, cognitive impairment, acute myocardial infarct and systolic hypertension. OH can also be asymptomatic or with atypical presentation: falls, gait disorders and confusion. Psychotropic agents (antipsychotics, sedatives, antidepressants), and cardiovascular drugs (antihypertensive agents, vasodilators, diuretics) were associated with OH. Discussion: If the hypothesis of causality between drug treatment and OH is confirmed, the identification of the involved drugs could be of value for the prevention of OH and its complications. In this context, the Working Group Pharmacology Pharmacotherapy and Pharmaceutical Care of the Belgian Society of Gerontology and Geriatrics proposes to conduct a multicentre study to assess the prevalence of OH in Belgian acute geriatrics units and its relationship with drugs. Source

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