Rochefort, Belgium
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Muyldermans G.,OD Public Health and Surveillance | Ducoffre G.,OD Public Health and Surveillance | Leroy M.,OD Public Health and Surveillance | Dupont Y.,OD Public Health and Surveillance | And 96 more authors.
PLoS ONE | Year: 2016

In 1983 the sentinel laboratory network was established because of the need to describe the epidemiological evolution of infectious diseases. During the study period of 30 years (1983-2013), microbiology laboratories reported on weekly basis the laboratory diagnosed cases for a selection of infectious diseases. This resulted in a large longitudinal laboratory based database allowing to provide trends over time and distribution by person and place. During this period, adaptations to data collection were made due to changes in diagnostic methods and public health priorities, introduction and application of digital revolution, and multiple reorganizations of the laboratories. Since the surveillance network is dynamic, it necessitates a continuous evaluation to ensure that, over time, it continues to be representative of the general epidemiological trends in the country. Secondly the aim is to examine the robustness and stability of this surveillance system. Here we demonstrated that the flexibility of the data collection methodology by the sentinel laboratory network is unique and that adaptations do not affect the capacity of the system to follow trends. Therefore, the surveillance by this network is representative of the current epidemiological situation in Belgium. To our knowledge, no such surveillance network with such a long-term follow-up and demonstrated stability for multiple infectious diseases in the general population was earlier described. Furthermore, expected trends due to the implementation of vaccination or other events were accurately detected. The collected data obtained from this network allows interesting comparisons with other national and international information sources. © 2016 Muyldermans et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Blumental S.,Free University of Colombia | Sabbe M.,Scientific Institute of Public Health SIPH | Lepage P.,Free University of Colombia | Asscherickx W.,Algemeen Ziekenhuis Diest | And 100 more authors.
Archives of Disease in Childhood | Year: 2016

Background: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. Methods: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. Results: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/105 person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/105 person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had ≥ 1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/552) received acyclovir. Incidence of complicated hospitalised cases was 19/105 person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/106 and fatality ratio 0.2% among our cohort. Conclusions: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium.


The aim of the study was to evaluate the effects of exenatide on glycemic control and weight after 3 and 6 month treatment in patients failing glycemic control with metformin and a sulfonylurea. Our data clearly demonstrate a reduction in glycated hemoglobin as well as a marked weight loss at 3 and 6 month.


Poot F.,Free University of Colombia | Antoine E.,Clinique Notre Dame de Grace | Gravellier M.,Free University of Colombia | Hirtt J.,Free University of Colombia | And 6 more authors.
Acta Dermato-Venereologica | Year: 2011

Family history can provide important information about a patient's psychological status, and thus their disease risk. A multicentric case-control study on family dysfunction was performed on 59 patients with psoriasis (63.7%), atopic dermatitis (11.9%) or alopecia areata (25.4%), and 47 patients with minor skin problems (controls), all attending a dermatological clinic or a psychodermatological consultation. The mean age of subjects was 47.7 years in the cases and 48.8 years in the controls. Women represented 53% of cases and 62% of controls. Patients and controls frst completed the General Health Questionnaire (GHQ-12) and the Toronto Alexithymia Scale (TAS-20) questionnaire. The overall prevalence of anxiety and/or depression in cases was 43.3% (71.4% in atopic dermatitis). To collect the family history a genogram was built by the interviewer during a semi-structured interview. It can show dysfunction in the family, as it highlights alliances and ruptures, generational repetition of behaviours of dependence or vulnerability, and traumatic events. The mean (± standard deviation) genogram score was 6.7 ± 3.3 in the cases and 3.0 ± 2.4 in the controls (p < 0.001). The cases had three times the risk of having moderate family dysfunction compared with controls and 16 times the risk of having a severe family dysfunction. The genogram score was correlated with the severity of the disease as evaluated by the patient. In conclusion, family dysfunction may play an important role in the onset or the exacerbation of psoriasis, alopecia, and atopic dermatitis. © 2011 Acta Dermato-Venereologica.


Delefortrie Q.,Clinique Notre Dame de Grace | Schatt P.,Clinique Notre Dame de Grace | Grimmelprez A.,Clinique Notre Dame de Grace | Gohy P.,Clinique Notre Dame de Grace | And 3 more authors.
Clinical Biochemistry | Year: 2016

Background: Although colonoscopy associated with histopathological sampling remains the gold standard in the diagnostic and follow-up of inflammatory bowel disease (IBD), calprotectin is becoming an essential biomarker in gastroenterology. The aim of this work is to compare a newly developed kit (Liaison® Calprotectin - Diasorin®) and its two distinct extraction protocols (weighing and extraction device protocol) with a well established point of care test (Quantum Blue® - Bühlmann-Alere®) in terms of analytical performances and ability to detect relapses amongst a Crohn's population in follow-up. Methods: Stool specimens were collected over a six month period and were composed of control and Crohn's patients. Amongst the Crohn's population disease activity (active vs quiescent) was evaluated by gastroenterologists. Results: A significant difference was found between all three procedures in terms of calprotectin measurements (weighing protocol = 30.3 μg/g (median); stool extraction device protocol = 36.9 μg/g (median); Quantum Blue® (median) = 63; Friedman test, P value = 0.05). However, a good correlation was found between both extraction methods coupled with the Liaison® analyzer and between the Quantum Blue® (weighing protocol/extraction device protocol Rs = 0.844, P = 0.01; Quantum Blue®/extraction device protocol Rs = 0.708, P = 0.01; Quantum Blue®/weighing protocol, Rs = 0.808, P = 0.01). Finally, optimal cut-offs (and associated negative predictive values - NPV) for detecting relapses were in accordance with above results (Quantum Blue® 183.5 μg/g and NPV of 100% > extraction device protocol + Liaison® analyzer 124.5 μg/g and NPV of 93.5% > weighing protocol + Liaison® analyzer 106.5 μg/g and NPV of 95%). Conclusions: Although all three methods correlated well and had relatively good NPV in terms of detecting relapses amongst a Crohn's population in follow-up, the lack of any international standard is the origin of different optimal cut-offs between the three procedures. © 2015 The Canadian Society of Clinical Chemists.


Deltour D.,Clinique Notre Dame de Grace | Veys E.,Clinique Notre Dame de Grace
Acta Chirurgica Belgica | Year: 2011

Tailgut cysts, also called retro-rectal cystic hamartomas or mucin-secreting cysts, are uncommon vestigial masses. They can become complicated with infection or neoplastic degeneration. Surgery is the only treatment. We report here a case of a tailgut cyst in a 60-year-old female, that was discovered 10 years ago but not investigated.


Goudetsidis L.,Clinique Notre Dame de Grace | Titeca G.,Clinique Notre Dame de Grace | Poot F.,Clinique Notre Dame de Grace
Revue Medicale de Bruxelles | Year: 2015

Introduction: Orofacial granulomatosis represents a group of pathologies characterized by a granulomatous inflammation of the face and the oral mucosa. Its etiology is unknown. Since the macrocheilitis resulting from an inflammation could be associated to different pathologies, an accurate diagnosis has to be established. Observation: A 74-year old woman developed a swelling of the inferior lip spreading towards the chin. No lesions was present on the oral mucosa. No other symptoms were reported. The biopsy and further exams concluded to an idiopathic orofacial granulomatosis. Triamcinolone 10 mg/ml was used as treatment and has allowed a lasting improvement of the swelling. Discussion: This rare observation, especially with an older patient, has allowed to illustrate the importance of an accurate diagnosis when facing a macrocheilitis. Indeed, macrocheilitis can be associated to pathologies such as Crohn disease, sarcoidosis or tuberculosis, requiring an appropriate care.


PubMed | Clinique Notre Dame de Grace and Center Hospitalier Regional Du Val Of Sambre
Type: Journal Article | Journal: Clinical biochemistry | Year: 2016

Although colonoscopy associated with histopathological sampling remains the gold standard in the diagnostic and follow-up of inflammatory bowel disease (IBD), calprotectin is becoming an essential biomarker in gastroenterology. The aim of this work is to compare a newly developed kit (Liaison Calprotectin - Diasorin) and its two distinct extraction protocols (weighing and extraction device protocol) with a well established point of care test (Quantum Blue - Bhlmann-Alere) in terms of analytical performances and ability to detect relapses amongst a Crohns population in follow-up.Stool specimens were collected over a six month period and were composed of control and Crohns patients. Amongst the Crohns population disease activity (active vs quiescent) was evaluated by gastroenterologists.A significant difference was found between all three procedures in terms of calprotectin measurements (weighing protocol=30.3g/g (median); stool extraction device protocol=36.9g/g (median); Quantum Blue (median)=63; Friedman test, P value=0.05). However, a good correlation was found between both extraction methods coupled with the Liaison analyzer and between the Quantum Blue (weighing protocol/extraction device protocol Rs=0.844, P=0.01; Quantum Blue/extraction device protocol Rs=0.708, P=0.01; Quantum Blue/weighing protocol, Rs=0.808, P=0.01). Finally, optimal cut-offs (and associated negative predictive values - NPV) for detecting relapses were in accordance with above results (Quantum Blue 183.5g/g and NPV of 100%>extraction device protocol+Liaison analyzer 124.5g/g and NPV of 93.5%>weighing protocol+Liaison analyzer 106.5g/g and NPV of 95%).Although all three methods correlated well and had relatively good NPV in terms of detecting relapses amongst a Crohns population in follow-up, the lack of any international standard is the origin of different optimal cut-offs between the three procedures.

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