Saint-Estève, France
Saint-Estève, France

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Edouard P.,Jean Monnet University | Codine P.,Clinique La Pinede | Codine P.,Montpellier University | Samozino P.,Jean Monnet University | And 5 more authors.
Journal of Science and Medicine in Sport | Year: 2013

Background: Isokinetic assessment of shoulder internal and external rotators is commonly used by clinicians to assess muscle performance and to guide rehabilitation. The reliability of isokinetic assessment is fundamental to track small but clinically relevant changes. Objectives: We aimed to analyze the absolute and relative reliability of strength imbalance indices such as peak torque ratios (ERconc/IRconc, ERecc/IRecc, ERecc/IRcon, IRecc/ERcon), bilateral concentric and eccentric strength ratios, and to examine the reliability of external rotator and internal rotator peak torque measured using a Biodex® dynamometer in the seated position. Design: Cross-sectional laboratory study. Methods: Forty-six healthy participants were tested twice with seven days between sessions, at 60. °/s and 120. °/s concentrically, and 30. °/s eccentrically. Results: Low to moderate relative reliability (intraclass correlation coefficient: 0.25-0.81) was found for unilateral and bilateral strength imbalance ratios. High intraclass correlation coefficient values (0.87-0.97) were found for peak torque. Concerning absolute reliability, the standard error of measurement ranged from 9.1 to 25.6% for strength imbalance ratios and from 7.7 to 14.5% for peak torque measurements, and minimal detectable change ranged from 25.2 to 71% for strength imbalance ratios and from 21.3 to 40.2% for peak torque measurements. Conclusions: The standard error of measurement and minimal detectable change reported in the present study should be taken into account when evaluating the individual longitudinal changes in clinical practice. © 2012 Sports Medicine Australia.


Grimaldi-Bensouda L.,LA SER | Grimaldi-Bensouda L.,French National Conservatory of Arts and Crafts | Grimaldi-Bensouda L.,French Institute of Health and Medical Research | Alperovitch A.,French Institute of Health and Medical Research | And 71 more authors.
Annals of the Rheumatic Diseases | Year: 2015

Background: Gout therapy includes xanthine oxidase inhibitors (XOI) and colchicine, which have both been associated with decreased cardiovascular risk. However, their effects on major cardiac events, such as myocardial infarction (MI), need to be investigated further. Objectives: To investigate whether XOIs and colchicine are associated with decreased risk of MI. Methods: This case-control study compared patients with first-ever MI and matched controls. Cases were recruited from the Pharmacoepidemiological General Research on MI registry. Controls were selected from a referent population (n=8444) from general practice settings. Results: The study sample consisted of 2277 MI patients and 4849 matched controls. Use of allopurinol was reported by 3.1% of cases and 3.8 of controls, and 1.1% of cases and controls used colchicine. The adjusted OR (95% CI) for MI with allopurinol use was 0.80 (0.59 to 1.09). When using less stringent matching criteria that allowed for inclusion of 2593 cases and 5185 controls, the adjusted OR was 0.73 (0.54 to 0.99). Similar results were found on analysis by sex and hypertension status. Colchicine used was not associated with a decreased risk of MI (aOR=1.17 (0.70 to 1.93)). Conclusions: Allopurinol may be associated with a reduced risk of MI. No decreased risk of MI was found in colchicine users. Besides its urate-lowering property, allopurinol might have a cardioprotective effect.


Grimaldi-Bensouda L.,LA SER | Grimaldi-Bensouda L.,French National Conservatory of Arts and Crafts | Grimaldi-Bensouda L.,French Institute of Health and Medical Research | Alperovitch A.,French Institute of Health and Medical Research | And 73 more authors.
Annals of the Rheumatic Diseases | Year: 2014

Background: Gout therapy includes xanthine oxidase inhibitors (XOI) and colchicine, which have both been associated with decreased cardiovascular risk. However, their effects on major cardiac events, such as myocardial infarction (MI), need to be investigated further. Objectives: To investigate whether XOIs and colchicine are associated with decreased risk of MI. Methods: This case-control study compared patients with first-ever MI and matched controls. Cases were recruited from the Pharmacoepidemiological General Research on MI registry. Controls were selected from a referent population (n=8444) from general practice settings. Results: The study sample consisted of 2277 MI patients and 4849 matched controls. Use of allopurinol was reported by 3.1% of cases and 3.8 of controls, and 1.1% of cases and controls used colchicine. The adjusted OR (95% CI) for MI with allopurinol use was 0.80 (0.59 to 1.09). When using less stringent matching criteria that allowed for inclusion of 2593 cases and 5185 controls, the adjusted OR was 0.73 (0.54 to 0.99). Similar results were found on analysis by sex and hypertension status. Colchicine used was not associated with a decreased risk of MI (aOR=1.17 (0.70 to 1.93)). Conclusions: Allopurinol may be associated with a reduced risk of MI. No decreased risk of MI was found in colchicine users. Besides its urate-lowering property, allopurinol might have a cardioprotective effect. © 2014 BMJ Publishing Group Ltd & European League Against Rheumatism.


Bernard P.L.,Montpellier University | Edouard P.,Jean Monnet University | Tallon G.,Montpellier University | Perrey S.,Montpellier University | And 4 more authors.
Journal de Traumatologie du Sport | Year: 2016

The aim of the present study was to compare the influence of three rest intervals of 30, 60 and 180 seconds randomly applied between two sets of five isokinetic contractions of flexor-extensor knee muscles in a cohort composed of 14 men (32.5 ± 8 years). The comparison of the isokinetic values measured during the first set of each evaluation session showed no significant differences (0.55 < P < 0.80). The analysis of the time and rest interval interaction demonstrated no significant difference between the isokinetic measures obtained after the rest intervals for peak torque of the quadriceps and of the hamstrings and for the mean power of the quadriceps and the hamstrings. These findings raise questions about a strict energetic approach and a future research should analyze the interaction of force production and fatigue phenomena in relation to the rest interval. © 2016 Elsevier Masson SAS


Bernard P.-L.,Montpellier University | Amato M.,Center Les Cadrans Solaires | Degache F.,Jean Monnet University | Edouard P.,Jean Monnet University | And 4 more authors.
Annals of Physical and Rehabilitation Medicine | Year: 2012

Background: Although peak torque has shown acceptable reproducibility, this may not be the case with two other often used parameters: time to peak torque (TPT) and the angle of peak torque (APT). Those two parameters should be used for the characterization of muscular adaptations in athletes. Methods: The isokinetic performance of the knee extensors and flexors in both limbs was measured in 29 male athletes. The experimental protocol consisted of three consecutive identical paradigms separated by 45. min breaks. Each test consisted of four maximal concentric efforts performed at 60 and 180°/s. Reproducibility was quantified by the standard error measurement (SEM), the coefficient of variation (CV) and by means of intra-class correlation coefficients (ICCs) with the calculation of 6 forms of ICCs. Results: Using ICC as the indicator of reproducibility, the correlations for TPT of both limbs showed a range of 0.51-0.65 in extension and 0.50-0.63 in flexion. For APT, the values were 0.46-0.60 and 0.51-0.81, respectively. In addition, the calculated standard error of measurement (SEM) and CV scores confirmed the low level of absolute reproducibility. Conclusions: Due to their low reproducibility, neither TPT nor APT can serve as independent isokinetic parameters of knee flexor and extensor performance. So, given its reproducibility level, TPT and APT should not be used for the characterization of muscular adaptations in athletes. © 2012 Elsevier Masson SAS.

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