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Donini L.M.,University of Rome La Sapienza | Donini L.M.,Clinical Rehabilitation Institute | Cuzzolaro M.,University of Rome La Sapienza | Cuzzolaro M.,Clinical Rehabilitation Institute | Spera G.,University of Rome La Sapienza
Agro Food Industry Hi-Tech | Year: 2010

Obesity incidence and prevalence rates are extremely high and growing, in both sexes and in all age groups. The consequences on physical and psychological status, on disability, on the quality of life call for complex and coordinated action strategies, both in terms of primary prevention and in terms of treatment and secondary prevention. The definition of these strategies must concern authorities in charge of public health, research centres, scientific societies, basic and specialist health facilities. On the basis of international scientific literature and experiences carried out in Italy, the rehabilitation approach proves to be the most appropriate for the treatment of obesity: it is best suited for the chronic features and the presence of co-morbidity and disabilities and the need to have various professionals involved in the treatment. This approach must be adjusted to the clinical, functional and psychological features of the patient and must become intensive when the level of seriousness and co-morbidity of obesity is high, when the psychic status is particularly fragile and disturbed, when the impact on disability and the quality of life of the patient is burdensome and invalidating. Source

Rondanelli M.,University of Pavia | Opizzi A.,University of Pavia | Perna S.,University of Pavia | Faliva M.,University of Pavia | And 10 more authors.
Endocrine | Year: 2013

This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and l-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m2) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group. We observed that consumption of the dietary supplement was associated with a significantly greater decrease in insulin resistance, assessed by homostasis model assessment (p < 0.001), leptin/adiponectin ratio (p < 0.04), respiratory quotient (p < 0.008). LDL-cholesterol levels (p < 0.01). Moreover, statistically significant differences were recorded between the two groups in relation to urinary norepinephrine levels (p < 0.001). Leptin, ghrelin, C-reactive protein decreased and resting energy expenditure increased significantly in the supplemented group (p < 0.05, 0.03, 0.02 and 0,02 respectively), but not in the placebo group; adiponectin decreased significantly in the placebo group (0.001) but not in the supplemented group, although no statistical significance between the groups was elicited. BMI, fat mass (assessed by DXA) and vascular endothelial growth factor significantly decreased, whilst the resting energy expenditure/free fat mass significantly increased in both groups. In general, a greater change was recorded in the supplemented group compared to the placebo, although no statistically significant difference between the two groups was recorded. These results suggest that the combination of bioactive food ingredients studied might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions. © 2012 The Author(s). Source

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