Clinical Pathology Operative Unit

San Donato di Ninea, Italy

Clinical Pathology Operative Unit

San Donato di Ninea, Italy
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Dogliotti G.,University of Milan | Dozio E.,University of Milan | Agrifoglio M.,University of Milan | Costa E.,Clinical Pathology Operative Unit | And 5 more authors.
In Vivo | Year: 2011

Background/Aim: The purpose of this study was to assess the oxidative stress of aircraft pilots by evaluating different markers of oxidative stress and any imbalance between free radicals and antioxidants in plasma. Patients and Methods: A group of 13 supersonic aircraft pilots, following regular exercise and personalized diet, were compared with a group of 40 healthy controls. Oxidative stress indicators, such as reactive oxidative metabolites, carbonyl proteins, 8-hydroxy-2-deoxyguanosine and total antioxidant status, were evaluated after three months of intense flight. Results: Reactive oxygen metabolites, carbonyl protein and 8-hydroxy-2-deoxyguanosine plasma levels did not differ in supersonic aircraft pilots and healthy controls. The two groups also had similar total antioxidant status levels. Conclusion: We suggest that supersonic aircraft pilots working at high altitude, even if exposed to physiological stresses, can, with proper diet, regular exercise and periodical medical examinations, maintain a healthy balance between oxidant and antioxidant status.


Lombardi G.,Irccs Instituto Ortopedico Galeazzi | Corsetti R.,Cannondale | Lanteri P.,Irccs Instituto Ortopedico Galeazzi | Grasso D.,Irccs Instituto Ortopedico Galeazzi | And 10 more authors.
Scandinavian Journal of Medicine and Science in Sports | Year: 2014

Calcium and phosphate are essential for cell functions, and their serum concentrations result from the balance between intestinal absorption, bony storage, and urinary excretion. Fibroblast growth factor 23 (FGF23), expressed by osteocytes and osteoblasts, acts in the kidney, leading to hypophosphatemia and low 1,25-dihydroxycholecalciferol synthesis, but suppresses parathyroid function. The aim of this study was to explore the effects of a high-energy demanding cycling race on this bone-kidney-parathyroid axis. We studied nine cyclists during the 2011 Giro d'Italia stage race. Pre-analytical and analytical phases followed academic and anti-doping recommendations. Serum parathyroid hormone (PTH), 25(OH)D, total calcium, inorganic phosphorus, and plasma FGF23 were measured on days -1, 12, and 22 and corrected for changes in plasma volume. Dietary calcium and phosphorus, anthropometric parameters (height, weight, and body mass index) and indexes of metabolic effort (net energy expenditure, power output) were recorded. Dietary calcium and phosphorus intakes were kept at the same levels throughout the race. Twenty-five (OH)D, PTH, and calcium concentrations remained stable. FGF23 increased 50% with a positive correlation with the indexes of metabolic effort and, consequently, phosphorous decreased, although only in the first half. The strong metabolic effort acts on the bone-kidney-parathyroid system, and the rise in FGF23 plasma concentration might be aimed at maintaining calcium and phosphorus homeostasis. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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