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San Marino, Italy

Bianchi V.E.,Center for Clinical Nutrition | Ribisl P.M.,Wake forest University
Journal of Cardiopulmonary Rehabilitation and Prevention | Year: 2015

Reactive oxygen species (ROS) are implicated in cardiovascular disease and in the pathogenesis of type 2 diabetes and its complications, and it has been shown to increase insulin resistance. The purpose of this study was to examine the effect of aerobic exercise training and weight loss on ROS in overweight and obese patients as applied in a community clinical setting.


Bianchi V.E.,Center for Clinical Nutrition | Herbert W.G.,Virginia Polytechnic Institute and State University | Myers J.,Stanford University | Ribisl P.M.,Wake forest University | And 2 more authors.
Sleep and Breathing | Year: 2015

Purpose: This study seeks to determine the risks for obstructive sleep apnea (OSA) and cardiometabolic disease (CMR) in elderly patients with mild-moderate abdominal aortic aneurysms (AAA).Methods: Three hundred two elderly patients with diagnosed small AAA disease were subjects. CMR was assessed by several biomarkers, with special focus on the Lipid Accumulation Product (LAP) and the Triglyceride-Glucose Index (TyG Index), two validated screening indicators of CMR related to central obesity and insulin resistance, respectively. Analysis of OSA risk was assessed with the Berlin Questionnaire.Results: The patients (60.6 %) had increased risk of OSA; those at high risk also were at increased (p < 0.05) risk for CMR (15/25 biomarkers).Conclusions: As a group, elderly AAA patients are at risk for both OSA and cardiometabolic disease. Given that OSA and CMR may both amplify risk for AAA expansion, these patients should be screened for OSA, and when indicated, referred for definitive evaluation and treatment. © 2014, Springer-Verlag Berlin Heidelberg.

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