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Orsolic N.,University of Zagreb | Bevanda M.,Clinical Hospital Mostar | Kujundi N.,University of Zagreb | Plazonic A.,Agency for Medicinal Products and Medical Devices | And 2 more authors.
Planta Medica

The presence of peritoneal carcinomatosis arising from gastrointestinal and gynecologic tumors is associated with a poor prognosis. Animal models of peritoneal carcinomatosis are important in the evaluation of new treatment modalities. The purpose of this study was to investigate the effect of local chemoimmunotherapy and hyperthermal intraperitoneal chemotherapy (HIPEC) in an animal model of induced peritoneal carcinomatosis in the mouse. For induction of peritoneal carcinomatosis, cells from transplantable mammary carcinoma (MCa) were implanted intraperitoneally in CBA mice. Seven or 3 days before implantation of MCa cells (5×103) the mice were injected with lyophilized water extract from Caucalis platycarpos L. (CPL; 200mgkg 1) into the abdominal cavity. Immediately after implantation of MCa cells in the abdominal cavity, mice were treated two times with 2mL of saline that was heated either at 37°C or 43°C (hyperthermal treatment) and cytostatics (doxorubicin 20mgkg1, cisplatin 10mgkg1, mitomycin 5mgkg1, 5-FU 150mgkg1). We followed the survival of animals and the side effects appearing with different forms of treatment. CPL increased the life span of mice with peritoneal carcinomatosis without hyperthermal treatment (ILS%=32.55%) but showed no effect on the life span of mice with hyperthermal treatment (ILS%=1.44). Combined treatment with CPL and cytostatics (CIS, DOX, and MIT) significantly affected the development of peritoneal carcinomatosis and increased the survival of mice (ILS% 37°C=144.17, 415.46, and 124.13, ILS% 43°C=311.42, 200.74, and 138.33, respectively). However, intraperitoneal chemotherapy with 5-FU alone resulted in greater survival time of mice than the treatment with 5-FU + CPL. Results suggest the synergistic effect of hyperthermia, chemotherapy, and immunotherapy. CPL significantly increases the antitumor activity of the hyperthermic chemotherapy and the survival rate of mice with peritoneal carcinomatosis. The stimulative effect of CPL on immunomodulation may be a possible mechanism which protects mice from developing peritoneal carcinomatosis and reduces the side effects of chemotherapy, increasing the life span of mice. © Georg Thieme Verlag KG Stuttgart · New York. Source

Gabric Panduric D.,University of Zagreb | Seiwerth S.,University of Zagreb | Manojlovic S.,Clinical Hospital Center Dubrava | Vucicevic Boras V.,University of Zagreb | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences

A 77 year old male was referred to the Department of Oral surgery due to the palatal lesion located on the border between hard and soft palate which was exophytic, asymptomatic and slowly growing. Excisional biopsy was performed, histopathological finding was consistent with diagnosis of sialoadenoma papiliferum. List of possible clinical and histological differential diagnosis is included. Source

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