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Casale M.,Biomedical University of Rome | Pappacena M.,Biomedical University of Rome | Potena M.,Biomedical University of Rome | Vesperini E.,Biomedical University of Rome | And 5 more authors.
Inflammation and Allergy - Drug Targets | Year: 2011

Nasal polyps (NP) are common benign degeneration of nasal sinus mucosa with a prevalence around 4% in the adult population. The causes are still uncertain but there is a strong association with allergy, infection, asthma and aspirin sensitivity. Histologically, the presence of a large quantity of extracellular fluid, mast cell degranulation and eosinophilia has been demonstrated. Typically the patients show nasal obstruction, anosmia and rhinorrhoea. Nasal endoscopic examination and CT imaging allow evaluation of the disease extention. A combined medical and surgical treatment is recommended for symptoms control in preventing symptomatic NP recurrence. We will review the current knowledge in the pathogenesis and treatment of this complex disease entity. © 2011 Bentham Science Publishers Ltd. Source


Casale M.,Biomedical University of Rome | Pappacena M.,Biomedical University of Rome | Setola R.,Biomedical University of Rome | Soda P.,Biomedical University of Rome | And 4 more authors.
American Journal of Rhinology and Allergy | Year: 2010

Background: Nasal obstruction is one of the most frequent symptoms in the ear, nose, and throat (ENT) setting. It can be evaluated either subjectively or objectively. In a subjective way, a visual analog scale (VAS) and the Sino-Nasal Outcome Test 20 (SNOT 20) can rapidly quantify the degree of obstruction, whereas the most commonly used objective methods are nasal endoscopy and active anterior rhinomanometry (AAR). It is still a matter of controversy to what extent the sense of nasal obstruction is associated with objective measures for nasal space and airflow. The aim of the study was to evaluate nasal breathing before and after functional nasal surgery by video-rhino-hygrometer (VRH) comparing the results with widely accepted methods. Methods: Twenty patient candidates for septoplasty and inferior turbinate reduction were included in the study. SNOT-20, VAS, nasal endoscopy, and AAR were analyzed and compared with VRH values. Results: Before surgery VRH showed variability of nasal respiratory flow between individuals and between nostrils. After surgery we had an increase (p < 0.05) of airflow in both nostrils. VRH data were found to be correlated with VAS and SNOT-20 values (p < 0.05) both pre- and postoperatively. Despite the statistically significant correlation of AAR with SNOT-20 and VAS, no statistically significant correlation between AAR and VRH was found. Conclusion: VRH provides an immediate, easy, and noninvasive assessment of nasal respiration. For these reasons it can be used, in association with rhinoscopic data and other instrumental tests, to evaluate nasal breathing in daily ENT practice. Copyright © 2010, OceanSide Publications, Inc. Source


Alfirevic T.,University of Zagreb | Balac D.,University of Zagreb | Susic M.,University of Zagreb | Vrdoljak D.V.,Institute for Tumuors | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

In the so far published literature, no data regarding postoperative symptoms in patients after surgery of small jaw cyst exist. The aim of this research was to determine possible differences in postoperative recovery of the patients after the surgical removal of small jaw cysts. The study involved 35 participants with small jaw cysts, 51.4% male and 48.6% female, age range from 16 to 81 years of age. Cyst location, size and kind of the cysts, including the presence of oedema, swelling, bad breath, consummation of analgesics and antibiotics (pre-and post-operative), and consummation of certain food and drink, The subjective sensation of pain and the working capability of the patients were assesed. The most common symptoms were swelling which appeared on the first, the third and the seventh day in the following percentages: the first day 97.1%, the third day 60% and the seventh day 25.7%. Other difficulties (pain, difficulties with speech and sleeping, bad breath) appeared in a significantly smaller amount, not exceeding 20% out of the total number of the participants. It is also important to mention that 8.6% of the participants had difficulties while eating. The rest of the difficulties (increased temperature, difficulties while eating) did not occuror they did not exceed the frequency of 1 (2.9%).20% of the cysts smaller than 1 cm, followed by 54.3% of the cysts which were between 1 and 2 cm large, and 25.7% of the cysts large between 2 and 3 cm. The most commonly diagnosed were radicular inflammatory cysts (71.4%), followed by the residual cysts (20%), and the rest of the cysts (follicular, lateral periodontal, odontogenic keratocysts) were found in 2.9%.The number of 15 patients experienced troubles sleeping after the procedure, while 73.33% of them were taking antibiotics. The total number of 27 patients experienced difficulties with eating during the period of 14 postoperative days. The total number of 23 participants received analgesics postoperatively, while only two of them did not experience difficulties with feeding. Statistical analysis included Fishers exact test, Chi-square test, Kruskal-Wallis test. The cyst location is not connected to postoperative difficulties, however postoperative difficulties are more frequent with larger cysts. Postoperative difficulties of patients after the surgical removal of small jaw cysts are mostly a result of their own subjective perception. The patients taking postoperative antibiotic and/or analgesic therapy reported a higher intensity of post-operative difficulties. Source


Vucicevic Boras V.,University of Zagreb | Vucicevic Boras V.,Clinical Hospital Center Rebro | Marinovic B.,Clinical Hospital Center Rebro | Marinovic B.,University of Zagreb | And 8 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

We report a case of a 40-year-old male patient who was referred to our department with oral and skin lesions. The skin lesions were pruritic vesicles with clear contents on the erythematous base and were present for the past 9 months. The patient was otherwise healthy and was not taking any medication. Oral lesions were multiple erosions covered with pseudomembranes. Histology finding suggested lichenoid reaction. Direct immunofluorescence showed presence of IgG along the dermo-epidermal border, and the indirect immunofluorescence was negative. Enzyme linked immunoassay was positive for BP-180. The diagnosis of lichen planus pemphigoides was established. Source

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