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Bitola, Macedonia

Avramovski P.,Clinical Hospital | Sikole A.,Ss. Cyril and Methodius University of Skopje
Korean Journal of Internal Medicine | Year: 2012

Background/Aims: The aim of this study was to compare the progression of bone mass loss in chronic hemodialysis patients (CHPs) with that in general population patients (GPPs) over an 18-month period. Methods: The control group consisted of 60 patients (aged 57.5 ± 10.9 years) with a glomerular filtration rate > 60 mL/min/1.73 m2. The study group included 80 patients undergoing hemodialysis (aged 59.3 ± 11.8 years; duration of dialysis 5.47 ± 5.16 years). Bone mineral density (BMD) testing was conducted in both groups using dual energy X-ray absorptiometry at hip and lumbar spine regions at baseline and after 18 months. Biochemical parameters (albumin, C-reactive protein, calcium, ionized calcium, alkaline phosphatase, and parathyroid hormone) were determined in all participants using standard laboratory procedures. Results: The mean values of BMD (average hip + lumbar spine) were 0.900 ± 0.14 g/cm2 and 0.866 ± 0.14 g/cm2 in the GPP and 0.823 ± 0.16 g/cm2 and 0.769 ± 0.13 g/cm2 in the CHP groups at baseline and 18 months, respectively. The statistical significance (p value) of hip bone loss progression over 18 months was 0.0577 for GPP and 0.0002 for CHP, whereas that of lumbar spine bone loss progression was 0.6820 for GPP and 0.5389 for CHP. Conclusions: The of progression bone mass loss was significantly greater in CHP than in GPP. Bone mass loss was evident even over 1 month, albeit in only the CHP with accelerated osteoporosis. © 2012 The Korean Association of Internal Medicine. Source


Objectives: The study was designed to determine the accuracy of using systolic (SBP) and diastolic blood pressure (DBP), mean arterial pressure (MAP), and increase of blood pressure (BP) to predict Preeclampsia (PE). Materials and Methods: We examined 300 normotensive and 100 PE pregnancies divided in two subgroups: mild (n=67) and severe (n=33) PE. The patients had a BP check in first and second trimester (SBP, DBP, and MAP). Results: We found out significant difference between the groups, but what is more important is that the difference in BP values (especially diastolic and MAP) existed before the pathological increase of the BP above the normal values. This was happening most often after 31 wg (at 92.5%) and less often after 26 wg (at 7.5%) at the pregnancies with mild PE while at the pregnancies with severe PE, 18,2% had increased tension after 21 wg; 24% in the period of 26-30 wg and 57.58% after 31 wg. Conclusion: Based on the results we could conclude that when BP is measured in the first or second trimester of pregnancy, the MAP is a better predictor for PE than SBP and DBP. © Polskie Towarzystwo Ginekologiczne. Source


Pletersek A.,IDS D.o.o | Sok M.,Clinical Hospital
Journal of Medical Systems | Year: 2012

This work demonstrates the developed application for disinfection control by the sensing of chemical agents. The objective was to develop an Automatic Disinfectant Tracker (ADT) that would verify the disinfection of the hands of nurses, doctors, staff, patients, and visitors in hospitals within a required time frame. We have successfully investigated the development of hand disinfection control mechanisms and demonstrated two approaches, both based on the wireless Ultra-High-Frequency-based Radio-Frequency Identification (UHF-RFID) technology. The 100 % efficacy of detecting propanol and ethanol concentration was achieved by using the static disinfectant control (SDC-ADT) method. The time domain response provides an accurate determination of their performance in practice simply by measuring the applied disinfectant concentration and the duration of application. The present paper resulted from the measurements of a capacitive chemical sensor fabricated in the Laboratory for Microelectronics, (LMFE) and on measurements, based on a commercially available resistive type of sensor. A graphic user interface (IDS-GUI) is designed to successfully set the logger parameters and display the results. © 2012 Springer Science+Business Media, LLC. Source


Alvarez M.,Hospital Rio Hortega | Pastor E.,C.S. Rondilla I | Eiros J.M.,Clinical Hospital
Infezioni in Medicina | Year: 2012

Spain presents a high level of systemic antibiotic consumption and subsequently shows important rates of bacterial resistance. Diverse parameters explain the uneven distribution of their consumption such as the epidemiology of infectious processes, population-dependent factors, and factors dependent on the prescribing doctor. The aim of this study was to investigate demographic parameters that may affect antibiotic consumption. We carried out a retrospective longitudinal study from 2001 to 2005 on the basis of antibiotic consumption data provided by the information system of the drugstore "Concylia". The consumption indicator used is the number of defined daily doses per 1000 inhabitants per day (DID). The area studied was the region of Castile and Leon, with nine provinces and eleven health districts. Global consumption per health district under study was as follows: Avila (22.37 DID), Zamora (21.83 DID), Salamanca (21.0 DID), Soria (20.67 DID), Palencia (18.97 DID), Leon (17.56 DID), Burgos (16.59 DID), Segovia (16.50 DID), East Valladolid (16.36 DID), The Bierzo (16 DID) and the lowest consumer, West Valladolid (13.46 DID). Different patterns of consumption were found in the study period, according to the variability of infectious diseases and demographic factors such as population age and population density. Significant area-dependent global consumption differences were observed in relation to acute respiratory infections and population-dependent factors. The differences were more marked when studying the geographical distribution of the consumption of the principal active ingredients. Source


Britez M.E.M.,Clinical Hospital | Llano C.C.,Instituto Nacional Del Cancer | Chaux A.,Research Laboratory
European Journal of Plastic Surgery | Year: 2012

Background Silicone gel-containing breast implants have been widely used for aesthetic and reconstructive mammoplasty. The development of a periprosthetic capsule is considered a local reparative process against the breast implant in which a variety of inflammatory cells may appear. Nevertheless, only few reports have evaluated the immunophenotypes of those inflammatory cells. Herein, we aim to provide more information in this regard evaluating 40 patients with breast implants. Methods We studied the immunophenotype of the inflammatory cells of capsular implants using antibodies against lymphocytes (CD3, CD4, CD8, CD20, CD45, and CD30) and histiocytes (CD68). Percentages of CD3 and CD20 positive cells were compared using the unpaired Student'st test. Fisher's test was also used to compare Baker grades by implant type, implant profile, and location and the presence of inflammatory cells by implant type. Results The associations between Baker grades and implant type and location were statistically nonsignificant (p00.42 in both cases). However, the use of low profile implants was significantly associated (p00.002) with a higher proportion of Baker grades 3 and 4. We found evidence of inflammation in 92.5 % of all implant capsules, with a statistically significant (p00.036) higher proportion in textured breast implants. T cells predominated over B cells. Textured implants elicited a more marked response to T cells than smooth implants, with a similar proportion of helper and cytotoxic T cells. Textured implants showed statistically significant higher percentages of CD3 positive cells than smooth implants. Percentages of CD20 positive cells were similar in textured and smooth implants. Conclusions These results suggest that textured breast implants might induce a stronger local T cell immune response. Our findings could shed some light to understand the association of silicone breast implants and some cases of anaplastic large cell lymphomas. Level of Evidence: Level III, prognostic study. © The Author(s) 2012. Source

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