Emergency Clinical Hospital of Bucharest

of Bucharest, Romania

Emergency Clinical Hospital of Bucharest

of Bucharest, Romania
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Popescu-Valceanu H.-C.,National Institute of Diabetes | Popescu-Valceanu H.-C.,Carol Davila University of Medicine and Pharmacy | Bratu M.,Emergency Clinical Hospital of Bucharest | Stancu D.M.,National Institute of Diabetes | And 12 more authors.
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2015

Background and aims: Epidemiological evidence suggests that people with diabetes have a significantly increased risk of developing various cancers. The aim of the study was to assess the frequency of various cancers in diabetic patients admitted in the National Institute of Diabetes Nutrition and Metabolic Diseases "Prof. N.C. Paulescu" between 01.01.2011 and 01.09.2014. Material and methods: The study analyzed a total of 24.104 admissions, corresponding to a total of 13.960 patients. A total of 520 hospitalizations with a diagnosis of cancer and diabetes were indentified. Finally, 298 patients meeting the inclusion and exclusion criteria were included in the study. For these patients, personal history, clinical and laboratory data were assessed. Results: The prevalence of cancer in hospitalized diabetic patients was 2.13%. The most frequent types of cancer (number of cases) were: breast - 63 patients, colorectal - 45 patients, pancreatic - 37 patients, lung - 31 patients and prostate - 20 patients. Conclusions: Our data showed that the most common form of cancer associated with diabetes was breast cancer (21%), followed by colorectal cancer (15.10%) and pancreatic cancer (12.42%). Further prospective studies are needed in the long term on larger study groups to evaluate the incidence and prevalence of various forms of cancer in the diabetic population.


Pitha J.,Institute for Clinical and Experimental Medicine | Kralova Lesna I.,Institute for Clinical and Experimental Medicine | Hubacek J.A.,Institute for Clinical and Experimental Medicine | Sekerkova A.,Institute of Clinical and Experimental Medicine | And 10 more authors.
Atherosclerosis | Year: 2016

Background: The connexin 37 (Cx37) gene is considered to be a candidate gene for ischemic heart disease (IHD). We analyzed the association between the C1019 > T (Pro319 > Ser) variant of the Cx37 gene and IHD in patients in the Czech Republic, Croatia, Hungary and Romania with regard to the presence/absence of selected cardiovascular risk factors (RF). In a complementary study, we analyzed the association between the Cx37 gene and circulating stem and endothelial progenitor cells in healthy women. Methods: The study population comprised 2396 patients (663 women) with IHD. The control population comprised 2476 subjects (1, 337 women). Additionally, in 662 healthy women, the association between the Cx37 gene and circulating stem and endothelial progenitor cells was analyzed. Results: The strongest protective effect of the Cx37 T allele was detected in non-smoking patients without diabetes mellitus and hypertension (OR 0.610, 95% CI 0.377-0.990); a similar effect was found in non-smoking men (OR 0.781, 95% CI 0.628-0.971); weaker effect was found in non-smoking women (OR 0.768, 95% CI 0.560-1.050). In non-smoking healthy women, stem cells were significantly higher in TT than in CT and CC carriers (p for trend 0.011). Additionally, non-smoking TT carriers had significantly higher number of stem cells than past and current smoking TT carriers (p for trend = 0.006); no such trend was found in CT and CC carriers. Conclusions: The protective effect of the T allele of the Cx37 gene might be strongly modified by smoking; in women, this effect could be mediated through stem cells. © 2015 Elsevier Ireland Ltd.


PubMed | Emergency Clinical Hospital of Bucharest, Osijek University Hospital, Josip Juraj Strossmayer University of Osijek, Cedars Sinai Medical Center and 4 more.
Type: | Journal: Atherosclerosis | Year: 2016

The connexin 37 (Cx37) gene is considered to be a candidate gene for ischemic heart disease (IHD). We analyzed the association between the C1019 > T (Pro319 > Ser) variant of the Cx37 gene and IHD in patients in the Czech Republic, Croatia, Hungary and Romania with regard to the presence/absence of selected cardiovascular risk factors (RF). In a complementary study, we analyzed the association between the Cx37 gene and circulating stem and endothelial progenitor cells in healthy women.The study population comprised 2396 patients (663 women) with IHD. The control population comprised 2476 subjects (1, 337 women). Additionally, in 662 healthy women, the association between the Cx37 gene and circulating stem and endothelial progenitor cells was analyzed.The strongest protective effect of the Cx37 T allele was detected in non-smoking patients without diabetes mellitus and hypertension (OR 0.610, 95% CI 0.377-0.990); a similar effect was found in non-smoking men (OR 0.781, 95% CI 0.628-0.971); weaker effect was found in non-smoking women (OR 0.768, 95% CI 0.560-1.050). In non-smoking healthy women, stem cells were significantly higher in TT than in CT and CC carriers (p for trend 0.011). Additionally, non-smoking TT carriers had significantly higher number of stem cells than past and current smoking TT carriers (p for trend = 0.006); no such trend was found in CT and CC carriers.The protective effect of the T allele of the Cx37 gene might be strongly modified by smoking; in women, this effect could be mediated through stem cells.


Neagu T.P.,Emergency Clinical Hospital of Bucharest | Neagu T.P.,Carol Davila University of Medicine and Pharmacy | Enache V.,Emergency Clinical Hospital of Bucharest | Cocolos I.,Emergency Clinical Hospital of Bucharest | And 6 more authors.
Romanian Journal of Morphology and Embryology | Year: 2016

There are many studies that investigate indirect and direct fracture healing but few mention the effect of periosteum stripping on consolidation of fractures. Most of these studies use only one method of osteosynthesis for each group. Therefore, we reported a new developed murine model in order to assess if limited periosteum stripping influence significantly the quality of the fracture healing process by comparing two different osteosynthesis methods to reduce simultaneously bilateral femur fractures. We applied the experimental protocol for a number of 12 rats. We used plates and screws to reduce femoral osteotomy for the right hind limb and intramedullary Kirschner wire for the left hind limb. Clinical, radiological and histological assessments were made for a period of eight weeks. The absence of a healthy hind limb led to a slower healing process based on the histological findings and to implant failure based on radiological findings. In summary, complete fracture healing was not achieved during this experimental study. Therefore, we consider that future studies are needed for a better understanding of the effects of periosteum removal on the fracture healing process. © 2016, Editura Academiei Romane. All rights reserved.


Oprita B.,Emergency Clinical Hospital of Bucharest | Atena G.D.,Emergency Clinical Hospital of Bucharest | Aignatoaie B.,Emergency Clinical Hospital of Bucharest
Therapeutics, Pharmacology and Clinical Toxicology | Year: 2012

When determining whether to observe, admit, transfer, or discharge a person who has beenpoisoned, there are several factors to consider. For unstable patients, admission to an intensive care unitis appropriate, and transfer to a tertiary care facility should be considered, especially with children. Forstable patients, the amount of observation time is based on the half-life of a medication, the amountingested, and the formulation. Any patient who develops signs or symptoms of toxicity that do not reverseduring the observation period should be admitted for further observation.[6] Triage is the initialassessment and sorting of patients in an emergency setting to determine clinical priority of need and, insome emergency departments (Eds), appropriate area for treatment. Overcrowding of EDs makes accuratetriage category assignment a priority if patient safety and timeliness of care are to be assured.[29]. Thepurpose of this research consists in the formulation of a pre-therapeutic and prognostic score, correlatingvital parameters of patients, toxicology and post-therapy scores, so we can decide whether to maintainthe patient in the Emergency Department for treatment, to discharge him/her in safety conditions or toadmit him/her in Toxicology Unit. © 2012.


PubMed | Emergency Clinical Hospital of Bucharest
Type: Journal Article | Journal: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | Year: 2016

There are many studies that investigate indirect and direct fracture healing but few mention the effect of periosteum stripping on consolidation of fractures. Most of these studies use only one method of osteosynthesis for each group. Therefore, we reported a new developed murine model in order to assess if limited periosteum stripping influence significantly the quality of the fracture healing process by comparing two different osteosynthesis methods to reduce simultaneously bilateral femur fractures. We applied the experimental protocol for a number of 12 rats. We used plates and screws to reduce femoral osteotomy for the right hind limb and intramedullary Kirschner wire for the left hind limb. Clinical, radiological and histological assessments were made for a period of eight weeks. The absence of a healthy hind limb led to a slower healing process based on the histological findings and to implant failure based on radiological findings. In summary, complete fracture healing was not achieved during this experimental study. Therefore, we consider that future studies are needed for a better understanding of the effects of periosteum removal on the fracture healing process.


PubMed | Emergency Clinical Hospital of Bucharest
Type: Journal Article | Journal: Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | Year: 2016

Osteosynthesis using Kirschner (K) wires and plates with screws were compared on the same subject in a previous experimental protocol, but none of them led to fracture healing. We designed a new murine study in order to compare this two methods on different subjects in order to obtain histological proofs of which one is better and to see how limited periosteum removal influence fracture healing. Divided in two equal groups, femoral osteotomies were performed on 30 Brown Norway rats, then reduced using plates and screws in the OPS (osteosynthesis using plates and screws) group and using K-wires in the OIKW (osteosynthesis using Kirschner wire) group. The animals underwent clinical, radiological and histological assessment for eight weeks. The quality of the fracture healing was associated with a higher number of osteocytes/microscopic field at eight weeks. The difference between the groups regarding the number of osteocytes inside lacuna was statistically significant (t-test for equal variances not assumed, p=0.001), which confirms a mean difference of 32 cellsmicroscopic field (mf) with a 95% confidence interval of 15-50 cellsmf. In conclusion, limited periosteum removal did not influence negatively fracture healing. Therefore, we considered that osteosynthesis using plates and screws led to better results compared to fracture fixation using K-wires.

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