Clinical Biophysics International Research Group

Lugano, Switzerland

Clinical Biophysics International Research Group

Lugano, Switzerland
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Pokorny J.,Academy of Sciences of the Czech Republic | Pokorny J.,ASCR Institute of Physics Prague | Foletti A.,Institute of Translational Pharmacology | Foletti A.,Clinical Biophysics International Research Group | And 2 more authors.
Pharmaceuticals | Year: 2015

Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy. © 2015 by the authors; licensee MDPI, Basel, Switzerland.


Foletti A.,National Research Council Italy | Foletti A.,Clinical Biophysics International Research Group | Cozzolino M.,University of Milan
Progress in Electromagnetics Research Symposium | Year: 2015

Chronic Kidney Disease (CKD) and its subsequent complications and consequences are an increasing concern in general population. A biophysical integrated approach in early stages of CKD was investigated in 30 patients with a 12-month follow-up. A clinical approach based on the use of an electro medical device (Medselect 729) was employed following previous reports as well as the procedure of electromagnetic information transfer through aqueous systems. Interestingly, we observed a significant increase in the estimated glomerular filtration rate (e GFR) according to CKD-EPI formula (+11.57 ml/min; +18.43%, p < 0.0001). Beside further studies are certainly recommended, a biophysical integrated approach in the management of early stages of Chronic Kidney Disease seems actually to be feasible, effective, and promising.


Ferrara I.,Clinical Biophysics International Research Group | Foletti A.,Clinical Biophysics International Research Group | Foletti A.,National Research Council Italy
Progress in Electromagnetics Research Symposium | Year: 2015

Refractory gynecological infections are often very difficult to treat. The need for new strategies in their management is therefore continuously increasing. Some researchers have recently pointed up that microorganisms could emit specific electromagnetic signals. Moreover electromagnetic signals could be able to yield response from immune system. The aim of this study was to assess the possibility to employ electromagnetic signals from swabs of refractory gynecological infections to rise a response of the immune system able to erase them. Twenty-two consecutive patients with refractory gynecological infections, since at least 3 months, participate into this study employing an electro medical device (Med Matrix) to perform the electromagnetic information delivery procedure. Vaginal swabs was picked up for microbiological assessment at baseline and after 7 days. Out of 22 swabs performed, 15 were positive for microbiological assessment at baseline. Out of the 15 positive at baseline only 2 were still positive after one week of biophysical treatment (p < 0.0031). Biophysical treatment of refractory gynecological infections seems to be an useful and promising second line clinical tool.


Foletti A.,CNR Institute of Neuroscience | Foletti A.,Clinical Biophysics International Research Group | Pokorny J.,Academy of Sciences of the Czech Republic
Electromagnetic Biology and Medicine | Year: 2015

Since biophysical treatment has been reported to be effective in the general management of pain, we decided to assess the specific effect and treatment duration of this therapeutic strategy in low back pain. We were interested in verifying the possibility that a single clinical procedure could reduce pain and improve patients' quality of life within a period of three months. An Electromagnetic Information Transfer Through Aqueous System was employed to record endogenous therapeutic signals from each individual using an electromagnetic recording device (Med Select 729). A highly significant reduction in the Roland Morris low back pain and disability questionnaire score was observed after 3 months following a single biophysical intervention (11.83 ± 6 at baseline versus 2.3 ± 3.25 at 3 months, p<0.0001). This preliminary report provides further evidence of the theoretical implications and clinical applications of Quantum Electro Dynamic concepts in biology and medicine. © 2015 Informa Healthcare USA, Inc. All rights reserved.


Foletti A.,CNR Institute of Neuroscience | Foletti A.,Clinical Biophysics International Research Group | Baron P.,Clinical Biophysics International Research Group | Sclauzero E.,Clinical Biophysics International Research Group | And 3 more authors.
Journal of Biological Regulators and Homeostatic Agents | Year: 2014

Pain management is a daily part of current medical practice. The aim of this pilot study was to assess the efficacy of a biophysical procedure (Med Select 729) compared to a usual pain killer drug (Ibuprofen), and to placebo in order to disclose some effective procedures to be employed especially in elderly people with multiple comorbidities, in patients with allergy to chemical drugs or previous side effects, in non-responders to usual medications, and in chronic diseases to reduce overload. A total of 66 patients were divided in 3 groups. After one week of biophysical therapy they showed similar effect to ibuprofen and after one month the statistical significance was achieved with p<0.02 in comparison to placebo. We conclude that biophysical therapy was shown to be an effective and safe procedure for the management of pain in current medical practice. Copyright © by BIOLIFE, s.a.s.


PubMed | CNR Institute of Neuroscience and Clinical Biophysics International Research Group
Type: Comparative Study | Journal: Journal of biological regulators and homeostatic agents | Year: 2014

Pain management is a daily part of current medical practice. The aim of this pilot study was to assess the efficacy of a biophysical procedure (Med Select 729) compared to a usual pain killer drug (Ibuprofen), and to placebo in order to disclose some effective procedures to be employed especially in elderly people with multiple comorbidities, in patients with allergy to chemical drugs or previous side effects, in non-responders to usual medications, and in chronic diseases to reduce overload. A total of 66 patients were divided in 3 groups. After one week of biophysical therapy they showed similar effect to ibuprofen and after one month the statistical significance was achieved with p less than 0.02 in comparison to placebo. We conclude that biophysical therapy was shown to be an effective and safe procedure for the management of pain in current medical practice.

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