Clinical and Hospital Center Bezanijska Kosa

Belgrade, Serbia

Clinical and Hospital Center Bezanijska Kosa

Belgrade, Serbia

Time filter

Source Type

Filipovic B.F.,Clinical and Hospital Center Bezanijska Kosa | Randjelovic T.,Clinical and Hospital Center Bezanijska Kosa | Kovacevic N.,Institute for Digestive Disease | Milinic N.,Clinical and Hospital Center Bezanijska Kosa | And 3 more authors.
European Journal of Internal Medicine | Year: 2011

Background: To investigate differences in laboratory markers, nutritional status parameters and eating patterns among newly diagnosed patients with functional dyspepsia. Method: The investigation was performed on 180 newly diagnosed patients with functional dyspepsia, aged 20-79, which were referred to the gastroenterology unit of the Clinical and Hospital Center "Bezanijska Kosa" from April to October 2009. Rome II criteria were used for further classification. Results: ANOVA Bonferroni post hoc correction outlined that concentrations of serum magnesium and calcium were significantly lower in subjects with ulcer-like dyspepsia, while vitamin B12, glucose and immunoglobulin G level was significantly higher in group with dismotility-like dyspepsia. Statistical analysis revealed that the numbers of meal taken per day were significantly different. There was a statistical trend to skipping meals and to eat fast in patients with ulcer-like and dismotility-like functional dyspepsia when compared with non-specific dyspeptic subjects. Conclusion: Patients with ulcer-like functional dyspepsia suffered from epigastric pain and burning and from heartburn, while persons with dismotility-like dyspepsia were complaining about postprandial fullness, bloating and early satiety. They skipped meals more frequently and avoided intake of certain supplies which, together with eating habits, provoked or emphasized the annoying symptoms. © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.


Filipovic B.F.,Clinical and Hospital Center Bezanijska Kosa | Gajic M.,Institute for Medical Statistics | Milinic N.,Clinical and Hospital Center Bezanijska Kosa | Milovanovic B.,Clinical and Hospital Center Bezanijska Kosa | And 3 more authors.
World Journal of Gastroenterology | Year: 2010

Aim: To investigate and compare efficacy and differences in the nutritional status evaluation of gastroenterology patients by application of two Methods: subjective global assessment (SGA) and nutritional risk index (NRI). Methods: The investigation was performed on 299 hospitalized patients, aged 18-84 years (average life span 55.57 ± 12.84), with different gastrointestinal pathology, admitted to the Department of Gastroenterohepatology, Clinical and Hospital Center "Bezanijska Kosa" during a period of 180 d. All the patients, after being informed in detail about the study and signing a written consent, underwent nutritional status analysis, which included two different nutritional indices: SGA and NRI, anthropometric parameters, bioelectrical impedance analysis, and biochemical markers, within 24 h of admission. Results: In our sample of 299 hospitalized patients, global malnutrition prevalence upon admission varied from 45.7% as assessed by the SGA to 63.9% by NRI. Two applied methods required different parameters for an adequate approach: glucose level (5.68 ± 1.06 mmol/L vs 4.83 ± 1.14 mmol/L, F = 10.63, P = 0.001); body mass index (26.03 ± 4.53 kg/m2 vs 18.17 ± 1.52 kg/m2, F = 58.36, P < 0.001); total body water (42.62 ± 7.98 kg vs 36.22 ± 9.32 kg, F = 7.95, P = 0.005); basal metabolic rate (1625.14 ± 304.91 kcal vs 1344.62 ± 219.08 kcal, F = 9.06, P = 0.003) were very important for SGA, and lymphocyte count was relevant for NRI: 25.56% ± 8.94% vs 21.77% ± 10.08%, F = 11.55, P = 0.001. The number of malnourished patients rose with the length of hospital stay according to both nutritional indices. The discriminative function analysis (DFA) delineated the following parameters as important for prediction of nutritional status according to SGA assessment: concentration of albumins, level of proteins, SGA score and body weight. The DFA extracted MAMC, glucose level and NRI scores were variables of importance for the prediction of whether admitted patients would be classified as well or malnourished. Conclusion: SGA showed higher sensitivity to predictor factors. Assessment of nutritional status requires a multidimensional approach, which includes different clinical indices and various nutritional parameters. © 2010 Baishideng.


Milovanovic B.,Clinical and Hospital Center Bezanijska Kosa | Milovanovic B.,University of Belgrade | Filipovic B.,Clinical and Hospital Center Bezanijska Kosa | Mutavdzin S.,Clinical and Hospital Center Bezanijska Kosa | And 4 more authors.
World Journal of Gastroenterology | Year: 2015

AIM: To investigate autonomic nervous function in patients with a diagnosis of gastroesophageal reflux disease (GERD). METHODS: The investigation was performed on 29 patients (14 men), aged 18-80 years (51.14 ± 18.34). Who Were Referred to Our Neurocardiology Lab. at the Clin. and Hosp. Ctr. bezanijska Kosa with A Diagn. of GERD. One Hundred Sixteen Healthy Volunteers Matched in Age and Sex with the Examinees Served As the Contr. Grp.. the Stud. Protocol Included the Eval. of Autonomic Funct. and Hemodynamic Status, Short-term Heart Rate Variability Anal., 24 H Ambulatory ECG Monitoring with Long-term HRV Anal. and 24 H Ambulatory Blood Pressure Monitoring. RESULTS: Pathologic Results of Cardiovasc. Reflex Test Were More Com. among Patients with Reflux Compared to the Contr. Grp.. Severe Autonomic Dysfunction Was Detected in 44.4% of Patients and in 7.9% of Controls . Parameters of Short-term Anal. of RR Variability, Which Are the Indicat. of Vagal Activ., Had Lower Values in Patients with GERD Than in the Contr. Grp.. Long-term HRV Anal. of Time-domain Parameters Indicated Lower Values in Patients with Reflux Dis. When Compared to the Contr. Grp.. Pwr. Spectral Anal. of Long-term HRV Revealed Lower Low-and High-frequency Values. Detailed 24 H Ambulatory Blood Pressure Anal. Showed Significantly Higher Values of Systolic Blood Pressure and Pulse Pressure in the Reflux Grp. Than in the Contr. Grp.. CONCLUSION: Patients with GERD Have Distortion of Sympathetic and Parasympathetic Components of the Autonomic Nerv. Syst., but Impaired Parasympathetic Funct. Appears More Congruent to GERD. 2015 Baishideng Publ. Grp. Inc. All Rights Reserved.


Filipovic B.R.,Niko Niko | Filipovic B.R.,University of Belgrade | Filipovic B.F.,Clinical and Hospital Center Bezanijska Kosa
World Journal of Gastroenterology | Year: 2014

Ulcerative colitis and Crohn's disease, commonly known as inflammatory bowel disease (IBD), draw attention from specialists of various disorders, including gastroenterology, psychiatry, and radiology. The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBD. The involvement of structures the limbic system, such as the anterior cingulate cortex, the prefrontal cortex, and the amygdala, paves the way for the discovery of the mechanisms underlying depression depression, anxiety, alexithymia, personality traits, and other psychological impairments following the onset of IBD. Psychiatric therapy in IBD patients is almost as important as the gastroenterological approach and consists of pharmacological treatment and psychotherapy. Neither of the available psychiatric treatment methods is considered the golden standard because both methods have side effects, and psychotropic medication can provoke the worsening of IBD symptoms. Thus, both approaches must be applied with awareness of the possibility of side effects. We suggest that psychiatrists and gastroenterologists work together to reach a consensus on IBD therapy to ensure success and to reduce side effects and relapse to the lowest possible rates. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.


Filipovic B.F.,University of Belgrade | Filipovic B.F.,Clinical and Hospital Center Bezanijska Kosa | Filipovic B.F.,Niko Niko | Randjelovic T.,University of Belgrade | And 10 more authors.
European Journal of Internal Medicine | Year: 2013

Background: Psychosocial stressors either acute or more sustained frequently precede the onset and exacerbation of the symptoms of the functional dyspepsia (FD). Depressive mood and quality of life have been already reported for interference in functional dyspepsia suffering patients. Methods: The examination were performed on 60 FD patients (30 females and 30 males), aged 20-79 years, 60 peptic ulcer subjects and 60 healthy volunteers in which we have investigate levels of anxiety and depression, personality traits and quality of life. Result: According to the Hamilton Depression and Anxiety Rating Scales, the population with FD had the average score which classified them into the group of patients with the moderate depression (20.57 ± 4.45). Personality traits estimation based on data obtained by the Eysenck personality questionnaire revealed higher neuroticism scores in the group with functional dyspepsia. Both parameters, level of the neuroticism and anxiety level, expressed highly significant level of mutual concordance. Patients with functional dyspepsia reported a greater adverse impact of symptoms of emotional distress and food and drink problems. Conclusion: Results are indicating that the depression and anxiety level is the highest in patients with functional dyspepsia and that anxiety level corroborates with the neuroticism level from the Eysenck scale. Psychological disturbances are influencing the quality of life mostly in patients with dyspepsia in the form of emotional distress and the problem with the food and beverage intake. © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.


Filipovic B.,University of Belgrade | Stijak L.,University of Belgrade | Filipovic B.,Clinical and Hospital Center Bezanijska Kosa
Journal of Medical Case Reports | Year: 2012

Introduction: Variations in the number and course of the testicular arteries, often coexisting with variations of the other branches arising from the abdominal aorta, are still reported to be of interest to urology surgeons. Case presentation: During a routine dissection course, an unusual origin of the double left testicular artery was observed in the cadaver of a 68-year-old Caucasian man who donated his body to the Institute of Anatomy. Conclusions: A deeper understanding of the variations of the testicular arteries is necessary for all physicians whose practice is related to the testicles and their vascular stalk. © 2012 Filipovic et al.; licensee BioMed Central Ltd.


PubMed | University of Belgrade and Clinical and Hospital Center Bezanijska Kosa
Type: | Journal: The American journal of case reports | Year: 2016

Carbohydrate tumor-associated antigen (CA 19-9) has been shown to be upregulated in other malignant tumors including gastric, ovarian, hepatocellular, and colorectal carcinoma as well as benign diseases of the biliary track such as pancreatitis, cholangitis, and choledocholithiasis. According to the available literature, in several cases of benign hydronephrosis and in a few cases of benign renal diseases, elevated CA 19-9 has been noted.A 58-year-old Caucasian male patient was admitted in our clinic with complaints about blunt abdominal pain in the past two-month period localized in the right lumbar region and irradiating into the right inguinal area, constipation, abdominal bloating, and intermittent hematuria. The concentration of serum CA 19-9 was 3500 U/mL. Urine cytology provided no signs of abnormality. Intravenous urography visualized right-sided pyelon and ureter duplex with the defect in contrast shade of the pyelon, caused by a stag horn calculus. Contrast added computerized axial tomography of the abdomen and pelvis visualized the pyelon casted concretion spreading throughout the right pyelon, with ureterohydronephrosis with the distal block for passage of the contrast to the distal part of the ureter.There is no doubt that CA 19-9 level is occasionally elevated in patients with obstructive urolithiasis as it was in our case. In the routine medical praxis, urolithiasis should not be neglected in the differential diagnosis of elevated concentrations of CA 19-9 marker.


Milisavljevic N.,Clinical and Hospital Center Bezanijska kosa | Cvetkovic M.,Clinical and Hospital Center Bezanijska kosa | Nikolic G.,Clinical and Hospital Center Bezanijska kosa | Filipovic B.,Clinical and Hospital Center Bezanijska kosa | Milinic N.,Clinical and Hospital Center Bezanijska kosa
Vojnosanitetski Pregled | Year: 2013

Introduction. The association between celiac disease and eating disorders has been very rarely reported. This is the first report on celiac disease associated with bulimia in this part of Europe. Case report. An adult female patient with history of bulimia and one uncomplicated pregnancy was admitted to the Gastroenterology Department, due to long lasting dyspeptic symptoms, constipation, major weight loss and fatigue. After positive serological screening, the diagnosis of celiac disease was confirmed with histopathology examination of duodenal biopsy specimen. Conclusion. Complicated interactions between celiac disease and bulimia can make them difficult to diagnose and treat. It is important to consider the presence of celiac disease in patients with bulimia and gastrointestinal symptoms.


Filipovic B.,Clinical and Hospital Center Bezanijska Kosa | Kovcevic N.,Institute for Digestive Diseases | Randjelovic T.,Clinical and Hospital Center Bezanijska Kosa | Kostic S.,Clinical and Hospital Center Bezanijska Kosa | Filipovic B.,Niko Niko
Hepato-Gastroenterology | Year: 2011

Background/Aims: Malnutrition appears to be a major and noticeable problem for hospitalized patients and often present in patients with gastrointestinal diseases. This study attempts to evaluate differences in nutritional status parameters and nutritional state differences among hospitalized patients with various gastrointestinal diseases and disorders. Methodology: Our study included 154 males and 146 females, aged 18-84 years old, with various gastrointestinal diseases and disorders. All patients underwent baseline nutritional assessment, including subjective global assessment (SGA), anthropometric measurements, bioelectrical impedance analysis (BIA), and biochemical markers. Results: Prevalence of malnutrition was 45.7%. The highest prevalence was detected among patients suffering from gastrointestinal malignancies and chronic pancreatitis. All parameters decreased with malnourishment levels, except CRP and in-hospital stay which rose with malnourishment grade. SGA and length of hospital stay negatively correlated with all analyzed variables of nutritional assessment, except CRP. Conclusions: Patients suffering from gastrointestinal malignancies, inflammatory bowel disease and peptic ulcer disease have more pronounced level of malnutrition. Body mass index, triceps skin fold thickness, mid-arm circumference, MAMC, wrist circumference, total protein level, albumin, cholesterol, glucose level, lymphocyte count, basal metabolic rate, body fat mass, fat free mass, muscle mass, total body water and resistance appeared to be inversely correlated with malnutrition. However, CRP level correlated positively with the malnutrition severity. SGA malnutrition level is dependant of hospitalization length. © H.G.E. Update Medical Publishing S.A.


PubMed | Clinical and Hospital Center Bezanijska Kosa
Type: Journal Article | Journal: European journal of internal medicine | Year: 2011

To investigate differences in laboratory markers, nutritional status parameters and eating patterns among newly diagnosed patients with functional dyspepsia.The investigation was performed on 180 newly diagnosed patients with functional dyspepsia, aged 20-79, which were referred to the gastroenterology unit of the Clinical and Hospital Center Bezanijska Kosa from April to October 2009. Rome II criteria were used for further classification.ANOVA Bonferroni post hoc correction outlined that concentrations of serum magnesium and calcium were significantly lower in subjects with ulcer-like dyspepsia, while vitamin B12, glucose and immunoglobulin G level was significantly higher in group with dismotility-like dyspepsia. Statistical analysis revealed that the numbers of meal taken per day were significantly different. There was a statistical trend to skipping meals and to eat fast in patients with ulcer-like and dismotility-like functional dyspepsia when compared with non-specific dyspeptic subjects.Patients with ulcer-like functional dyspepsia suffered from epigastric pain and burning and from heartburn, while persons with dismotility-like dyspepsia were complaining about postprandial fullness, bloating and early satiety. They skipped meals more frequently and avoided intake of certain supplies which, together with eating habits, provoked or emphasized the annoying symptoms.

Loading Clinical and Hospital Center Bezanijska Kosa collaborators
Loading Clinical and Hospital Center Bezanijska Kosa collaborators