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Stefanello D.,University of Milan | Buracco P.,University of Turin | Sabattini S.,University of Bologna | Finotello R.,University of Liverpool | And 15 more authors.
Journal of the American Veterinary Medical Association | Year: 2015

Objective—To compare the Kiupel (2 categories) and Patnaik (3 categories) histologic grading systems for predicting the presence of metastasis at the time of initial examination in dogs with cutaneous mast cell tumors (MCTs). Design—Retrospective case series. Animals—386 client-owned dogs with cutaneous MCTs. Procedures—Medical records of dogs with newly diagnosed, histologically confirmed cutaneous MCTs that had undergone complete clinical staging were reviewed for clinical and histopathologic data. Results—All Patnaik grade 1 MCTs (n = 52) were classified as Kiupel low-grade MCTs, and all Patnaik grade 3 MCTs (43) were classified as Kiupel high-grade MCTs. Of the 291 Patnaik grade 2 MCTs, 243 (83.5%) were classified as Kiupel low-grade tumors, and 48 (16.5%) were classified as Kiupel high-grade MCTs. Dogs with Patnaik grade 3 MCTs were significantly more likely to have metastases at the time of initial examination than were dogs with grade 1 or 2 MCTs (OR, 5.46), and dogs with Kiupel high-grade MCTs were significantly more likely to have metastases than were dogs with Kiupel low-grade MCTs (OR, 2.54). However, 3 of 52 (5.8%) dogs with Patnaik grade 1 tumors, 48 of 291 (16.5%) dogs with Patnaik grade 2 tumors, and 44 of 295 (14.9%) dogs with Kiupel low-grade tumors had metastatic disease. Conclusions and Clinical Relevance—Findings indicated that in dogs with cutaneous MCTs, prognostication should not rely on histologic grade alone, regardless of grading system used, but should take into account results of clinical staging. © 2015, American Veterinary Medical Association. All rights reserved. Source

Mavropoulou A.,Clinica Veterinaria Gran Sasso | Guazzetti S.,Local Health Unit | Borghetti P.,University of Parma | De Angelis E.,University of Parma | Quintavalla C.,University of Parma
Veterinary Journal | Year: 2016

Inflammation plays an important role in the pathogenesis of congestive heart failure (CHF). In humans with CHF, increased production and high plasma concentrations of tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1, IL-8 and transforming growth factor-β (TGF-β) have been associated with disease progression and a negative prognosis. The aim of this study was to investigate whether differences in cytokine blood mRNA expression exist between clinically healthy dogs and dogs with myxomatous mitral valve disease (MMVD); to determine if the expression was related to the severity of MMVD, and to detect any correlations with echocardiographic parameters of cardiac remodelling. Twenty-three dogs with MMVD of varying severity and six clinically healthy dogs were included in the study. Whole blood samples were obtained for measurement of mRNA expression of IL-1α, IL-1β, IL-6, IL-8, TGF-β1, TNF-α by reverse transcriptase-PCR (RT-PCR).There were statistically significant differences between clinically healthy dogs and dogs with MMVD for IL-8 and TGF-β1 gene expression. IL-8 expression increased with increasing MMVD severity and TGF-β1 expression was higher in asymptomatic dogs with echocardiographic signs of cardiac remodelling (American College Veterinary Internal Medicine class B2) than in all other groups. These results could suggest the involvement of these cytokines at different stages of the disease. © 2016 Elsevier Ltd. Source

Bussadori R.,Clinica Veterinaria Gran Sasso | Provera A.,Clinica Veterinaria Gran Sasso | Martano M.,Ospedale DidatticoVeterinario ODV | Morello E.,Ospedale DidatticoVeterinario ODV | And 5 more authors.
Veterinary Journal | Year: 2011

Conventional treatment of idiopathic chylothorax (IC) involves thoracic duct (TD) ligation (with/without lymphagiography) combined with subphrenic pericardiectomy. Nine dogs and four cats with IC, which received intrathoracic omentalisation with TD en bloc ligation (not preceded by lymphangiography) and subphrenic pericardiectomy, were evaluated retrospectively. Seven of nine dogs and 3/4 cats were still alive and disease-free at the time of reporting (range 10-53 and 19-31. months, respectively). Clinical signs of IC did not decrease after the first surgery in one cat and one dog; in another dog clinical signs recurred after 5. months. Overall efficacy rate of this one-stage combined procedure was 77% (6. months), 73% (12. months), and 57% (24. months). Where a second surgery was performed in case of failure, the success rate in dogs was 89% (6. months) and 80% (24. months). Addition of pleural omentalisation to TD en bloc ligation and subphrenic pericardiectomy does not seem to improve results when compared with published data and at present does not seem advisable as a first choice. © 2010 Elsevier Ltd. Source

Domenech O.,Clinica Veterinaria Gran Sasso | Silva J.,Clinica Veterinaria Gran Sasso | Oliveira P.,Clinica Veterinaria Gran Sasso | Sala E.,Busto Arsizio Hospital | Bussadori C.,Clinica Veterinaria Gran Sasso
Journal of Veterinary Cardiology | Year: 2011

Objectives: Determine whether valve morphology, pulmonary annulus diameter, aortic/pulmonic annulus ratio, balloon-to-annulus ratio (BAR), pre-pulmonary balloon valvuloplasty (PBV), Doppler gradient, and residual Doppler gradient are independent predictors of immediate and long-term results after PBV in dogs as in humans. Animals, materials and methods: Retrospective study. Medical records of dogs that underwent PBV, from January 1999 to December 2008 were reviewed. All dogs with pre- and immediate (24 h) post-PBV echocardiographic examination were included. 126 dogs were selected. Immediate outcome was optimal when the dog survived the PBV and Doppler gradient was ≤50 mmHg. Long-term outcome (1 year) was optimal when the dog survived at least 1-year follow-up without symptoms and Doppler gradient was ≤50 mmHg. Results: Only pre-PBV Doppler gradient was identified as a significant independent predictor of immediate results (P < 0.001; OR 0.97, CI 0.96-0.98). Pre-PBV Doppler gradient and residual Doppler gradient were the only independent predictors of long-term results (P = 0.036; OR 0.98, CI 0.96-0.99 and P = 0.005; OR 0.95, CI 0.92-0.98, respectively). Conclusion: In dogs as in humans higher pre-PBV Doppler gradient is one of the most important independent predictor of suboptimal immediate and long-term results after PBV and must be considered before scheduling this procedure. Moreover higher valvar residual Doppler gradient is an important independent predictors of suboptimal long-term results. © 2010 Elsevier B.V. All rights reserved. Source

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