Clinica Universitaria de Dermatologia

Lisbon, Portugal

Clinica Universitaria de Dermatologia

Lisbon, Portugal
SEARCH FILTERS
Time filter
Source Type

Emerit I.,French National Center for Scientific Research | Antunes J.,Clinica Universitaria de Dermatologia | Silva J.M.,Clinica Universitaria de Dermatologia | Freitas J.,Clinica Universitaria de Dermatologia | And 2 more authors.
Photochemistry and Photobiology | Year: 2011

As previously described, Psoralen plus UVA (PUVA) therapy induces chromosome damage in psoriatic patients. This study evaluates whether these effects are transitory or persistent. In addition, we studied these effects after narrowband UVB (nUVB) and anti-tumor necrosis factor (TNF)-α treatments. Among 40 responder patients, 10 received PUVA, 10 nUVB, 10 Infliximab and 10 Etanercept. Disease activity was determined with Psoriasis Area and Severity Index. Chromosomal breakage was evaluated by the clastogenic factor (CF) test. Potential clastogenic agents, malondialdehyde (MDA) and TNF-α were measured. Before treatment, the plasma-adjusted clastogenic scores (ACS) of patients were increased. During treatment, a further increase in ACS was observed in both phototherapy groups. Chromosome damage persisted for PUVA patients at week 32, while it diminished after nUVB to ACS values lower than before treatment. MDA and TNF-α values were also increased at baseline. MDA decreased during treatment in all groups, but without reaching normal levels. Plasma TNF-α remained unchanged in PUVA and nUVB but decreased in both anti-TNF-α treatment groups. Psoriasis is accompanied by CF-induced chromosomal breakage that increases during PUVA and nUVB treatments. Plasma clastogenic activity persisted in the follow-up after PUVA, while after nUVB ACS returned to values even lower than baseline. Clastogenic activity during the induction phase with anti-TNF-α remained unchanged. Psoriasis is accompanied by clastogenic factor (CF)-induced chromosomal breakage that increases during Psoralen plus UVA (PUVA) and narrowband UVB (nUVB) treatments. CF+ patients were more likely to occur in patients with severe disease (Psoriasis Area and Severity Index > 20). Plasma clastogenic activity persisted in the follow-up after PUVA, while after nUVB clastogenic activity returned to values even lower than baseline. During the induction phase with anti-TNF-α treatments clastogenic activity remained unchanged. © 2011 The American Society of Photobiology.


Uva L.,Clinica Universitaria de Dermatologia | Miguel D.,Clinica Universitaria de Dermatologia | Pinheiro C.,Clinica Universitaria de Dermatologia | Antunes J.,Clinica Universitaria de Dermatologia | And 3 more authors.
International Journal of Endocrinology | Year: 2012

Psoriasis is a lifelong, chronic, and immune-mediated systemic disease, which affects approximately 1-3% of the Caucasian population. The different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity. The use of topical therapy remains a key component of the management of almost all psoriasis patients, and while mild disease is commonly treated only with topical agents, the use of topical therapy as adjuvant therapy in moderate-to-severe disease may also be helpful. This paper focuses on the cutaneous mechanisms of action of corticosteroids and on the currently available topical treatments, taking into account adverse effects, bioavailability, new combination treatments, and strategies to improve the safety of corticosteroids. It is established that the treatment choice should be tailored to match the individual patient's needs and his/her expectations, prescribing to each patient the most suitable vehicle. © 2012 Luís Uva et al.


PubMed | Clinica Universitaria de Dermatologia
Type: Case Reports | Journal: Tropical doctor | Year: 2011

Progressive disseminated histoplasmosis is frequently fatal in HIV patients, and the standard diagnostic techniques can cause treatment delay. Skin biopsy can help in the differential diagnosis, allowing also an earlier treatment initiation.

Loading Clinica Universitaria de Dermatologia collaborators
Loading Clinica Universitaria de Dermatologia collaborators