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Gonzalez-Mosquera A.,University of Santiago de Compostela | Seoane J.,University of Santiago de Compostela | Garcia-Caballero L.,University of Santiago de Compostela | Lopez-Jornet P.,Clinica Odontologica Universitaria | And 2 more authors.
British Journal of Oral and Maxillofacial Surgery | Year: 2012

Our aim was to assess wounds made by lasers (CO2 and Er,Cr:YSGG) for their epithelial architectural changes and width of damage. We allocated 60 Sprague-Dawley® rats into groups: glossectomy by CO2 laser at 3 different wattages (n = 10 in each); glossectomy by Er,Cr:YSGG laser at two different emissions (n = 10 in each), and a control group (n = 10). Histological examination assessed both prevalence and site of thermal artefacts for each group. Both lasers (CO2 and Er,Cr:YSGG) caused the same type of cytological artefacts. The 3 W Er,Cr:YSGG laser produced the fewest cytological artefacts/specimen, and was significantly different from the other experimental groups: 3 W CO2 laser (95% CI = 0.8 to 1.0); the 6 W CO2 laser (95% CI = 0.1 to 2.0) and the 10 W CO2 laser (95% CI = 1.1 to 3.0). CO2 lasers (3-10 W) generate epithelial damage that can simulate dysplastic changes with cytological atypia that affects mainly the basal and suprabasal layers. Irradiation with Er,CR:YSGG laser (2-4 W) produces significantly fewer cellular artefacts and less epithelial damage, which may be potentially useful for biopsy of oral mucosa. © 2011 The British Association of Oral and Maxillofacial Surgeons.


Lopez-Jornet P.,Clinica Odontologica Universitaria | Camacho-Alonso F.,Clinica Odontologica Universitaria | Salazar-Sanchez N.,Clinica Odontologica Universitaria
Journal of Oral Pathology and Medicine | Year: 2010

Background: The search for new drugs capable of controlling the symptoms and signs of oral lichen planus (OLP) with minimal side-effects remains an important challenge. Objective: A literature review is made to evaluate the effectiveness and safety of topical tacrolimus and pimecrolimus in the treatment of OLP. Material and method: A review was made of the studies published between 1999 and 2008 in relation to the topical application of tacrolimus and pimecrolimus in OLP. Results: The data obtained point to the need for larger randomized, placebo-controlled studies with carefully selected and standardized endpoints, to allow adequate comparison between treatments. The adverse effects were fundamentally of a local nature, and in particular included burning sensation in the application zone. All the studies consulted found the treatment to be effective over short periods of time, with lesion recurrences after suppression of the drug. The long-term safety remains to be established. Conclusion: There is need for larger placebo-controlled, randomized studies with carefully selected and standardized outcome measures. © 2009 John Wiley & Sons A/S.


Bermejo-Fenoll A.,Clinica Odontologica Universitaria | Sanchez-Siles M.,Clinica Odontologica Universitaria | Lopez-Jornet P.,Clinica Odontologica Universitaria | Camacho-Alonso F.,Clinica Odontologica Universitaria | Salazar-Sanchez N.,Clinica Odontologica Universitaria
Journal of Oral Pathology and Medicine | Year: 2010

Objectives: This study describes the clinicopathological characteristics of a group of patients with oral lichen planus (OLP) in south-eastern Spain. Materials and methods: A retrospective descriptive study was made of 550 patients clinically and histopathologically diagnosed with OLP in the period 1991-2007. Patient gender, age, the prevalence of hepatitis C, symptoms and malignization were recorded. The clinical forms were classified as reticular-papular and atrophic-erosive. Results: Of the 550 patients, 128 (23.3%) were men and 422 (76.7%) women. The mean age was 56.35 ± 13.67 years (range 14-91). The prevalence of hepatitis C was 3.5%. The red clinical forms were the most frequent, with 359 cases (64.2%). The lesions were asymptomatic in 159 patients (28.9%). Five patients developed oral squamous cell carcinoma (0.9%); none of these subjects was smokers. Conclusions: Patients with OLP present different clinical manifestations. Women were more frequently affected by the disease, and the malignant transformation rate was under 1%. © 2010 John Wiley & Sons A/S.

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