Villafranca di Verona, Italy
Villafranca di Verona, Italy

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Di Francesco V.,Clinica Geriatrica | Antonioli A.,Clinica Geriatrica | Fantin F.,Clinica Geriatrica | Bissoli L.,Clinica Geriatrica | And 2 more authors.
Biochimica Clinica | Year: 2010

The "anorexia of aging" is defined as a condition associated with reduced appetite and consequent decrease in food intake in apparently healthy elderly people; this may lead to malnutrition. It is still unclear if meal composition can affect this condition. The aim of this study was to evaluate satiety and hunger sensation as well as hormone concentrations after meals with different fat contents. Twelve aged healthy community-dwelling subjects and twelve younger controls were asked to score their hunger sensation, using a visual analogical scale, under fasting condition and at 30-min interval for up to 4 h after two 800-kcal meals, where 20% and 40% of the calories were derived from fats, respectively. Serum samples were collected at -30, 60, 120, and 240 min after meal to measure glucagon-like peptide 1 (GLP-1), acylated and desacylated ghrelin, triglycerides, glucose, and insulin. In the elderly group serum concentrations of GLP-1 were higher after the 40% fat meal than after the 20% fat meal. In this group, after the 40% fat meal a lower acylated to desacylated ghrelin ratio, higher triglycerides and a lower hunger sensation were also observed. In conclusion, in apparently healthy elderly people larger amounts of fat in meals increase the satiety signal from GLP-1 and lower the acylated to desacylated ratio of ghrelin, consequently decreasing hunger. These data may explain the reduction in calory intake often observed in elderly people and should be taken into account in planning their diet composition.


Di Francesco V.,UOC 3 Geriatria d.O. | Bissoli L.,Clinica Geriatrica
Rivista Italiana della Medicina di Laboratorio | Year: 2011

Malnutrition has been defined by the Council on Food and Nutrition of the American Medical Association as a functional, structural and developmental alteration of the organism, caused by a discrepancy between nutritional needs and intake (or utilization) of energy and essential nutrients. This condition has a high prevalence among elderly people. Malnutrition has medical and social causes, and it is a well-known morbidity and mortality risk factor. Nutrition status evaluation needs several diagnostic approaches such as clinical observation, laboratory indexes, and anthropometric measurements. Great attention should be paid to prevention of malnutrition through risk factor evaluation using a multidimensional approach, before evident clinical and biochemical abnormalities become apparent. © Springer 2011.

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