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Valencia, Spain

Castillo J.C.,Clinica Fiv Valencia | Dolz M.,Clinica Fiv Valencia | Moreno J.,Clinica Fiv Valencia | Gijon L.,Clinica Fiv Valencia | And 3 more authors.
Reproductive BioMedicine Online

This prospective observational study evaluated the efficacy and safety of oocyte-donation cycles triggered with a gonadotrophin-releasing hormone (GnRH) agonist without monitoring oestradiol concentrations during ovarian stimulation. A total of 97 oocyte donors received recombinant FSH (150-225/day) and GnRH antagonists (0.25 mg/day). Oocyte maturation was triggered with 0.2 mg triptorelin s.c. Donors aged 25.4 ± 4.1 years were stimulated for 8.8 ± 0.9 days and underwent 2.9 ± 0.5 (2-4) ultrasound assessments. Total FSH dose was 1703.4 ± 304.7 IU, antagonists were administered for 4.3 ± 1.0 days, 14.7 ± 8.8 oocytes were retrieved and there were no cases of ovarian hyperstimulation syndrome. Recipients (n = 123) aged 40.3 ± 3.4 years received 10.9 ± 4.3 oocytes, 88.7% of which were metaphase II. Intracytoplasmic sperm injection fertilization rate was 79% and 2.18 ± 0.6 (1-3) embryos were transferred. The pregnancy, clinical pregnancy and twin pregnancy rates were 64.2%, 57.7% and 19.7%, respectively. In conclusion, given the high efficacy and safety of the GnRH-antagonist protocol triggered with a GnRH agonist, the monitoring of oestradiol concentrations is not necessary. Ultrasound monitoring is enough for an adequate follow up of the stimulation cycle in oocyte donors. © 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Source

Castillo J.C.,Clinica Fiv Valencia | Ferrer R.,Clinica Fiv Valencia | Ferrero E.,Clinica Fiv Valencia | Moreno X.,Clinica Fiv Valencia | And 2 more authors.
Revista Iberoamericana de Fertilidad y Reproduccion Humana

Objetive: To evaluate degree of satisfaction, pain aspects and disturbing in normal life after oocyte donation using a protocol without hCG for oocyte final maturation. Material and methods: This is a prospective study including 43 oocyte donation cycles. Seven days after retrieval a checkup was set including multiple-choice questions to estimate the satisfaction with the process of donation. The visual analogue (VAS) scale was used to measure pain. The study was made between May - December 2009. Results: Mean age was 25,4 +- 4,1, stimulation days were 8,8 +- 0,9. The number of evaluations were 3 +- 0,5. Oocytes recovered were 17 +- 8,3. Return of menses occurred 4,9 +- 1,4 days after retrieval. Pain was 4,32 +- 10,2 (range 0 - 50) according to VAS. General satisfaction with the process was 9,7 +- 0,7. The number of evaluations was estimated as sufficient in 95,3% of cases. 97,7% reported minor interference with normal life. Most frequent symptoms were abdominal bloating (13,9%) and nausea/ vomit (4,6%), 83,7% of patients showed no complains. 90,7% felt perfectly well on control. 95,4% were prone to donate again and 100% would recommend friends and close relatives to be donors. Subgroup analysis according to oocytes retrieved (Group A < 15 and Group B ≥ 15) didn't show differences in any variable studied. Conclusions: The protocol described for oocyte donor without using hCG is related to a high degree of satisfaction with the process of donation and minimal pain after retrieval. Discomfort sensations are not increased even in case of high response. This protocol is related to positive attitudes with the process of oocyte donations and must be used particularly in donors. Source

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