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Malvasi A.,Santa Maria Hospital | Malvasi A.,Moscow Institute of Physics and Technology | Nejkovic L.,Clinic of Gynecology and Obstetrics Narodni Front | Tinelli A.,Moscow Institute of Physics and Technology
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: The effect of gestational age and other factors that could influence the outcome of an electric shock in pregnancy have not been defined yet. Objective of this study is to provide reliable data on medical issues linked to electric shock in pregnancy.Methods: Authors consulted the most important scientific databases investigating reactions to electric shock in pregnancy, analyzing mechanism of electric shock, gestational age at the time of injury, the post-shock complications, interval from injury to delivery and fetal and maternal outcome.Results: The spectrum of electrical injuries in pregnancy ranges from transient unpleasant sensation with no effect on the fetus to sudden maternal and fetal death. The clinical presentation of the fetal injury may manifest immediately or even postnataly. Reported outcomes include spontaneous abortion, placental abruption, cardiac arrhythmias, fetal burn and intrauterine fetal death. If the pregnancy is continued, decreased fetal movements and asphyxia, pathological fetal heart patterns, intrauterine fetal growth retardation, damage to the fetal central nervous system and oligoamnios can occur.Conclusions: More large prospective observational studies are necessary for a proper insight into the expected outcomes of the electric shock in pregnancy as well as for a final definition of monitoring procedures of such pregnancies. © 2015 Informa UK Ltd.

Papic-Obradovic M.,Clinic of Gynecology and Obstetrics Narodni Front | Jeftic B.,University of Belgrade | Matija L.,University of Belgrade
FME Transactions | Year: 2016

Cervical cancer is the second most common invasive cancer of the female genital tract. In this study, samples prepared for standard Pap test were used and examined using digital imaging software that analyzes the difference between reflected diffuse white light and reflected polarized light (opto-magnetic imaging spectrosopy) in order to detect normal, dysplastic and cancerous cells. A digital camera customized for taking OMIS pictures of samples and light-mater interaction software for optomagnetic image analysis guided the diagnostic decision to more refined distinction between normal smear and the one containing either dysplastic or cancerous cells. Since the application of OMIS enables detection of significant differences between standard Pap test categories, this method offers an advantage over classical methods in the area of early detection of suspicious cells. By this method it is possible to obtain the result that is not dependent on the capability, subjectivity, experience and knowledge of the practitioner. © Faculty of Mechanical Engineering, Belgrade.

Vivoda M.,Institute Of Public Health Of Serbia Dr Milan Jovanovic Batut | Arsic B.,Clinic of Gynecology and Obstetrics Narodni Front | Garalejic E.,Clinic of Gynecology and Obstetrics Narodni Front | Garalejic E.,University of Belgrade | And 2 more authors.
Srpski Arhiv za Celokupno Lekarstvo | Year: 2014

Introduction Chlamydia trachomatis infections are the most prevalent bacterial sexually transmitted infections recognized throughout the world. In the last few years, several studies have indicated that predisposition of C. trachomatis to persist within the host cell is recognized as a major factor in the pathogenesis of chlamydial infection. During persistent chlamydial infection, the stress protein hsp60 is synthesized continually as immunopathologic antigen. Antibodies to hsp60 are found in women with tubal occlusion, but these antibodies are not detected in women with the acute C. trachomatis infection, which indicates that hsp60 has an important role in pathogenesis of persistant chlamydial infection. Objective The aim of this study was to determine the role of chlamydial stress proteins (heat shock proteins) in pathogenesis of ectopic pregnancy. Methods The study included 40 women with ectopic pregnancy (experimental group) and 34 women with normal pregnancy (control group). C. trachomatis was detected in endocervical smears by direct immunofluorescence test, while specific antibodies against Chlamydia spp. and against hsp60 were detected by ELISA. Results DIF method detected the presence of C. trachomatis in 12.5% of women with the ectopic pregnancy and 17.6% of women with normal pregnancy. IgG antibodies against Chlamydia spp. were found in 57.5% of women with the ectopic pregnancy and 26.5% of women with normal pregnancy. IgA antibodies were positive in 37.5% of women with the ectopic pregnancy and 2.9% of women with normal pregnancy. IgG antibodies against hsp60 were positive in 37.5% of women with the ectopic pregnancy and 14.7% of women with normal pregnancy. Conclusion The results of this study have proven the correlation between the ectopic pregnancy and the presence of IgG antibodies to chlamydial hsp60.

Dimitrijevic D.,Clinic of Gynecology and Obstetrics Narodni Front | Vasiljevic M.,Clinic of Gynecology and Obstetrics Narodni Front | Anicic R.,Clinic of Gynecology and Obstetrics Narodni Front | Brankovic S.,Clinic of Gynecology and Obstetrics Narodni Front
Clinical and Experimental Obstetrics and Gynecology | Year: 2013

This investigation was a prospective study performed at the Gynecological Clinic "Narodni Front" in Belgrade. In the investigated group, endometrial hyperplasia, endometrial polyp, and myoma were diagnosed as the most frequent causes of bleeding during peri-menopause. The test group of patients was then subjected to hysterosonography in order to diagnose bleeding etiology, followed by hysteroscopy to confirm its etiology based on hysterosonography. Material was sent for histopathological analysis to definitely confirm the diagnosis. The aim of this study was to the compare the findings of hysterosonography and hysteroscopy to evaluate the sensitivity and efficacy of hysterosonography for diagnosing the etiology of uterine bleeding in perimenopausal women. In the diagnostics of submucosal myoma, endometrial hyperplasia, and endometrial polyps, hysterosonography has proven to be a good screening method. By its use for diagnosing intracavitary uterine pathology, and thus also the pathology of bleeding in perimenopausal women, in many cases hysteroscopy can be avoided. This is a method that is easy to perform, less invasive, less costly to perform, and is well-tolerated.

Skoric D.,University of Belgrade | Ivana J.,Clinic of Gynecology and Obstetrics Narodni Front | Tanja R.,Institute of Medical and Clinical Biochemistry | Jovana J.,University of Belgrade | And 2 more authors.
Journal of Pediatric Hematology/Oncology | Year: 2014

BACKGROUND: Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy. OBSERVATION: We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia. CONCLUSIONS: Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. © 2014 by Lippincott Williams & Wilkins.

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