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Dumache R.,Victor Babes University of Medicine and Pharmacy Timisoara | Rogobete A.F.,Clinic of Anaesthesia and Intensive Care | Rogobete A.F.,Victor Babes University of Medicine and Pharmacy Timisoara | Rogobete A.F.,West University of Timisoara | And 10 more authors.
Analytical Cellular Pathology | Year: 2015

Sepsis is one of the most common causes of death in critical patients. Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. Moreover, monitoring, evaluation, and therapy management often become extremely difficult for the clinician in this type of patients. Current methods of diagnosing sepsis vary based especially on the determination of biochemical-humoral markers, such as cytokines, components of the complement, and proinflammatory and anti-inflammatory compounds. Recent studies highlight the use of new biomarkers for sepsis, namely, miRNAs. miRNAs belong to a class of small, noncoding RNAs with an approximate content of 19-23 nucleotides. Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly. Moreover, its stability, specificity, and selectivity make miRNAs ideal candidates for sepsis biomarkers. In conclusion, we can affirm that stable species of circulating miRNAs represent potential biomarkers for monitoring the evolution of sepsis. © 2015 Raluca Dumache et al. Source


Bedreag O.H.,Clinic of Anaesthesia and Intensive Care | Bedreag O.H.,Victor Babes University of Medicine and Pharmacy Timisoara | Rogobete A.F.,Clinic of Anaesthesia and Intensive Care | Rogobete A.F.,Victor Babes University of Medicine and Pharmacy Timisoara | And 12 more authors.
Biomarkers and Genomic Medicine | Year: 2015

MicroRNAs species are short, noncoding RNAs formed of 19-24 nucleotides. MicroRNAs play an essential role in the regulation of the humoral biochemical processes, cellular proliferation, or other biological processes in the human body. Tissue injuries, biochemical dysfunction, and physiological imbalances are followed by a significant change in the expression of microRNAs in biological fluids. With the recent advances in bioanalysis techniques, it is now possible to identify the microRNA species in biological fluids in specific situations for polytrauma patients. In this paper, we present the importance and the clinical significance of using microRNAs as diagnostic biomarkers for critically ill polytrauma patients. © 2015. Source

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