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Casals G.,Institute Clinic of Gynaecology | Ordi J.,Institute dinvestigacions Biomediques August Pi i Sunyer IDIBAPS | Creus M.,Institute Clinic of Gynaecology | Fabregues F.,Institute Clinic of Gynaecology | And 3 more authors.
Reproductive BioMedicine Online | Year: 2010

The osteopontin: αvβ3 integrin complex has been proposed as a means of distinguishing receptive from non-receptive endometrium in clinical practice, thus offering new directions for the development of contraceptive approaches targeted to the endometrium as well as a better understanding of occult causes of infertility in women. Histological dating and immunohistochemical study were performed in control and study cycles in seven groups of women including 10 subjects per group and who received clomiphene citrate, ovarian stimulation for IVF, oral contraception, dehydrogesterone for endometrial luteal phase defect, two different regimens of hormone replacement therapy, or no treatment. Ten healthy fertile women served as a general control group. Osteopontin and αvβ3 integrin expression in the human endometrium was closely related to endometrial maturation and this was irrespective of the endometrium being in-phase or out-of-phase and the hormonal treatment (or no treatment) received. In conclusion, immunohistochemical assessment of the endometrium indicates that the use of osteopontin and αvβ3 integrin or the osteopontin: αvβ3 integrin complex as targets for the development of contraceptive approaches or the understanding of the pathogenesis of female infertility offer little benefit compared with simple histological dating. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.


Casals G.,Institute Clinic of Gynaecology | Ordi J.,University of Barcelona | Creus M.,Institute Clinic of Gynaecology | Fbregues F.,Institute Clinic of Gynaecology | And 3 more authors.
Human Reproduction | Year: 2012

Background To study endometrial receptivity in terms of osteopontin (OPN) and αvβ3 integrin expression and co-expression in infertile women with early stages of endometriosis.Methods We investigated the immunohistochemical expression and co-expression of OPN and αvβ3 integrin in the endometrium of 20 infertile patients with Stage I or II endometriosis as the only detectable cause of infertility, 20 infertile patients with unexplained infertility and 20 fertile women undergoing tubal sterilization. Two endometrial biopsies were performed during a single menstrual cycle (postovulatory Day 7 to 8 and 4 days later) in each subject. Results No statistically significant differences regarding OPN and αvβ3 integrin expression were found between infertile patients with endometriosis and the two control groups. There was no significant correlation between OPN and αvβ3 integrin staining intensity in the mid-luteal phase biopsies in any of the groups studied. Conclusions Endometrial OPN and αvβ3 integrin expression or co-expression is not impaired during the window of implantation in patients with Stage III endometriosis. Further studies are needed to determine whether these results imply normal endometrial receptivity in such patients or add to the increasing uncertainty about the clinical value of assessing the endometrium with these markers of implantation. © 2012 The Author.

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