ck Science Center

Claremont, CA, United States

ck Science Center

Claremont, CA, United States
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Milton J.G.,ck Science Center
European Physical Journal: Special Topics | Year: 2012

The extent to which the occurrence of falls, the dominant feature of human attempts to balance a stick at their fingertip, can be predicted is examined in the context of the "Dragon-King" hypothesis. For skilled stick balancers, fluctuations in the controlled variable, namely the vertical displacement angle θ, exhibit power law behaviors. When stick balancing is made less stable by either decreasing the length of the stick or by requiring the subject to balance the stick on the surface of a table tennis racket, systematic departures from the power law behaviors are observed in the range of large θ. This observation raises the possibility that the presence of departures from the power law in the large length scale region, possibly Dragon-Kings, may identify situations in which the occurrence of a fall is more imminent. However, whether or not Dragon-Kings are observed, there is a Weibull-type survival function for stick falling. The possibility that increased risk of falling can, at least to some extent, be predicted from fluctuations in the controlled variable before the event occurs has important implications for the development of preventative strategies for the management of phenomena ranging from earthquakes to epileptic seizures to falls in the elderly. © 2012 EDP Sciences and Springer.


Milton J.G.,ck Science Center
European Journal of Neuroscience | Year: 2012

Power-law behaviors in brain activity in healthy animals, in the form of neuronal avalanches, potentially benefit the computational activities of the brain, including information storage, transmission and processing. In contrast, power-law behaviors associated with seizures, in the form of epileptic quakes, potentially interfere with the brain's computational activities. This review draws attention to the potential roles played by homeostatic mechanisms and multistable time-delayed recurrent inhibitory loops in the generation of power-law phenomena. Moreover, it is suggested that distinctions between health and disease are scale-dependent. In other words, what is abnormal and defines disease it is not the propagation of neural activity but the propagation of activity in a neural population that is large enough to interfere with the normal activities of the brain. From this point of view, epilepsy is a disease that results from a failure of mechanisms, possibly located in part in the cortex itself or in the deep brain nuclei and brainstem, which truncate or otherwise confine the spatiotemporal scales of these power-law phenomena. © 2012 The Author. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.


Lundberg J.,Carleton University | McFarlane D.A.,ck Science Center
Geomorphology | Year: 2012

The Gomantong cave system of eastern Sabah, Malaysia, is well-known as an important site for harvesting edible bird-nests and, more recently, as a tourist attraction. Although the biology of the Gomantong system has been repeatedly studied, very little attention has been given to the geomorphology. Here, we report on the impact of geobiological modification in the development of the modern aspect of the cave, an important but little recognized feature of tropical caves. Basic modeling of the metabolic outputs from bats and birds (CO 2, H 2O, heat) reveals that post-speleogenetic biogenic corrosion can erode bedrock by between ~3.0mm/ka (1m/~300ka) and ~4.6mm/ka (1m/~200ka). Modeling at high densities of bats yields rates of corrosion of ~34mm/ka (or 1m/~30ka). Sub-aerial corrosion creates a previously undescribed speleological feature, the apse-flute, which is semicircular in cross-section and ~80cm wide. It is vertical regardless of rock properties, developing in parallel but apparently completely independently, and often unbroken from roof to floor. They end at a blind hemi-spherical top with no extraneous water source. Half-dome ceiling conch pockets are remnants of previous apse-fluting. Sub-cutaneous corrosion creates the floor-level guano notch formed by organic acid dissolution of bedrock in contact with guano. Speleogenetic assessment suggests that as much as 70-95% of the total volume of the modern cave may have been opened by direct subaerial biogenic dissolution and biogenically-induced collapse, and by sub-cutaneous removal of limestone, over a timescale of 1-2Ma. © 2011 Elsevier B.V.


Lundberg J.,Carleton University | McFarlane D.A.,ck Science Center
Quaternary Research | Year: 2012

A distinctive white sediment in the caves of Mulu, Sarawak, Borneo is a well-preserved tephra, representing a fluvially transported surface air-fall deposit, re-deposited inside the caves. We show that the tephra is not the Younger Toba Tephra, formerly considered as most likely. The shards are rod-shaped with elongate tubular vesicles; the largest grains ~170μm in length; of rhyolitic composition; and 87Sr/ 86Sr ratio of 0.70426±0.00001. U-Th dating of associated calcites suggest that the tephra was deposited before 125±4ka, and probably before 156±2ka. Grain size and distance from closest potential source suggests an eruption of VEI 7. Prevailing winds, grain size, thickness of deposit, location of potential sources, and Sr isotopic ratio limit the source to the Philippines. Comparisons with the literature give the best match geochemically with layer 1822 from Ku et al. (2009a), dated by ocean core stratigraphy to 189ka. This tephra represents a rare terrestrial repository indicating a very substantial Plinian/Ultra-Plinian eruption that covered the Mulu region of Borneo with ash, a region that rarely receives tephra from even the largest known eruptions in the vicinity. It likely will be a valuable chronostratigraphic marker for sedimentary, palaeontological and archaeological studies. © 2012 University of Washington.


Insperger T.,Budapest University of Technology and Economics | Milton J.,ck Science Center
Biological Cybernetics | Year: 2014

The effects of sensory input uncertainty, ε, on the stability of time-delayed human motor control are investigated by calculating the minimum stick length, ℓcritℓ crit, that can be stabilized in the inverted position for a given time delay, τ. Five control strategies often discussed in the context of human motor control are examined: three time-invariant controllers [proportional-derivative, proportional-derivative- acceleration (PDA), model predictive (MP) controllers] and two time-varying controllers [act-and-wait (AAW) and intermittent predictive controllers]. The uncertainties of the sensory input are modeled as a multiplicative term in the system output. Estimates based on the variability of neural spike trains and neural population responses suggest that ≈ 7ε ≈ 7 -13 %. It is found that for this range of uncertainty, a tapped delay-line type of MP controller is the most robust controller. In particular, this controller can stabilize inverted sticks of the length balanced by expert stick balancers (0.25-0.5 m when τ ≈ 0.08τ ≈ 0.08 s). However, a PDA controller becomes more effective when ε > 15 %. A comparison between ℓcritℓ crit for human stick balancing at the fingertip and balancing on the rubberized surface of a table tennis racket suggest that friction likely plays a role in balance control. Measurements of ℓcrit, τ, and a variability of the fluctuations in the vertical displacement angle, an estimate of ε, may make it possible to study the changes in control strategy as motor skill develops. © 2014 Springer-Verlag Berlin Heidelberg.


Thines B.C.,University of California at Berkeley | Thines B.C.,ck Science Center | Youn Y.,University of California at Berkeley | Duarte M.I.,University of California at Berkeley | And 3 more authors.
Journal of Experimental Botany | Year: 2014

Warm temperature promotes flowering in Arabidopsis thaliana and this response involves multiple signalling pathways. To understand the temporal dynamics of temperature perception, tests were carried out to determine if there was a daily window of enhanced sensitivity to warm temperature (28 C). Warm temperature applied during daytime, night-time, or continuously elicited earlier flowering, but the effects of each treatment were unequal. Plants exposed to warm night (WN) conditions flowered nearly as early as those in constant warm (CW) conditions, while treatment with warm days (WD) caused later flowering than either WN or CW. Flowering in each condition relied to varying degrees on the activity of CO, FT, PIF4, and PIF5, as well as the action of unknown genes. The combination of signalling pathways involved in flowering depended on the time of the temperature cue. WN treatments caused a significant advance in the rhythmic expression waveform of CO, which correlated with pronounced up-regulation of FT expression, while WD caused limited changes in CO expression and no stimulation of FT expression. WN- and WD-induced flowering was partially CO independent and, unexpectedly, dependent on PIF4 and PIF5. pif4-2, pif5-3, and pif4-2 pif5-3 mutants had delayed flowering under all three warm conditions. The double mutant was also late flowering in control conditions. In addition, WN conditions alone imposed selective changes to PIF4 and PIF5 expression. Thus, the PIF4 and PIF5 transcription factors promote flowering by at least two means: inducing FT expression in WN and acting outside of FT by an unknown mechanism in WD. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.


Higdon J.C.,ck Science Center | Lingenfelter R.E.,University of California at San Diego
Astrophysical Journal | Year: 2013

The Galactic spatial distribution of OB associations and their surrounding superbubbles (SBs) reflect the distribution of a wide range of important processes in our Galaxy. In particular, it can provide a three-dimensional measure not only of the major source distribution of Galactic cosmic rays, but also the Galactic star formation distribution, the Lyman continuum ionizing radiation distribution, the core-collapse supernova distribution, the neutron star and stellar black hole production distribution, and the principal source distribution of freshly synthesized elements. Thus, we construct a three-dimensional spatial model of the massive-star distribution based primarily on the emission of the H II envelopes that surround the giant SBs and are maintained by the ionizing radiation of the embedded O stars. The Galactic longitudinal distribution of the 205 μm N II radiation, emitted by these H II envelopes, is used to infer the spatial distribution of SBs. We find that the Galactic SB distribution is dominated by the contribution of massive-star clusters residing in the spiral arms. © 2013. The American Astronomical Society. All rights reserved..


Milton J.G.,ck Science Center
Journal of Neural Engineering | Year: 2011

Recent advances in the study of delay differential equations draw attention to the potential benefits of the interplay between random perturbations ('noise') and delay in neural control. The phenomena include transient stabilizations of unstable steady states by noise, control of fast movements using time-delayed feedback and the occurrence of long-lived delay-induced transients. In particular, this research suggests that the interplay between noise and delay necessitates the use of intermittent, discontinuous control strategies in which corrective movements are made only when controlled variables cross certain thresholds. A potential benefit of such strategies is that they may be optimal for minimizing energy expenditures associated with control. In this paper, the concepts are made accessible by introducing them through simple illustrative examples that can be readily reproduced using software packages, such as XPPAUT. © 2011 IOP Publishing Ltd.


The current era of science and science education began in the 17th century, made possible by the earlier spread of the printing press. Science remains embedded in its 17th century context, and it is precisely these Gutenberg-era foundations that the Internet is replacing with new ones. The directions in which this is likely to lead science, given the ways in which the Internet is altering our social organizations are discussed. © 2010 American Chemical Society.


Milton J.G.,ck Science Center
IFAC Proceedings Volumes (IFAC-PapersOnline) | Year: 2015

This special session provides an introduction for engineers to the applications of delay differential equations to biological control. Topics include the regulation of populations of organisms and neurons, the stabilization of unstable states and the design of drug delivery systems. © 2015, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

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