Civil Veterinary Hospital

Fāzilka, India

Civil Veterinary Hospital

Fāzilka, India
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Ahmad M.,Civil Veterinary Hospital | Khan M.N.,University of Agriculture at Faisalabad | Sajid M.S.,University of Agriculture at Faisalabad | Muhammad G.,University of Agriculture at Faisalabad | And 2 more authors.
Veterinaria Italiana | Year: 2017

This study describes the epidemiology, the economic significance of small ruminant fasciolosis in animals slaughtered in the abattoirs of the Sargodha district, Punjab, Pakistan between January and June 2012. In vivo fasciolicidal efficacy of commercially available compounds was examined using a randomised complete block design. Microscopically screened faecal samples revealed 40.51% positive animals for fasciolosis. The prevalent species included Fasciola hepatica (35.64%) and Fasciola gigantica (8.21%). Mixed infections were noted in 3.33% subjects. Prevalence rates were significantly higher in females (42.25%) than in males (39.52%; p < 0.05), and in adults (51.20%) compared to younger animals (33.98%; p < 0.05). The disease was recorded more often in emaciated animals (63.63%) followed in order by average (43.45%), thin (43.22%), and fat (32.12%) animals. Between January and June 2012, fasciolosis in Sargodha district, Punjab, Pakistan, was estimated to incur US$0.036 million and US$0.177 million direct (liver condemnation) and indirect (carcass depreciation) economic losses, respectively. In vivo fasciolicidal efficacy of oxyclozanide proved to be the most effective method of control, compared to triclabendazole, and levamisole. Results provide useful information on the frequency distribution of fasciolosis and its economic significance. Finally, data on in vivo fasciolicidal trials show that oxyclozanide is the most efficacious compound for the treatment of the disease in the district Sargodha, Punjab, Pakistan. © 2017, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G.Caporale". All rights reserved.

Saleem U.,Government College University at Faisalabad | Ahmad B.,University of Punjab | Rehman K.,University of Punjab | Mahmood S.,Lahore General Hosipital | And 2 more authors.
Pakistan Journal of Pharmaceutical Sciences | Year: 2012

Oxidative stress causes the generation of reactive oxygen species (ROS) that lead to nephrotoxicity. An aminoglycoside, gentamicin, has pronounced nephrotoxic effect in humans and animals and this study was planned to observe the nephro-protective effect of antioxidants, vitamin C and Nigella sativa oil. Serum creatinine, blood urea nitrogen, and antioxidant activity were measured as indicators of nephrotoxicity for all the groups of rabbits. Results showed that vitamin C and Nigella sativa oil both had nephro-protective effect as they lowered the values of nephrotoxicity indicators (serum creatinine, blood urea nitrogen, and antioxidant activity) as compared to gentamicin control group values. When these two antioxidants were given as combination, they proved to have synergistic nephroprotective effect.

Sharma S.,Civil Veterinary Hospital | Dhaliwal G.S.,Civil Veterinary Hospital
Indian Veterinary Journal | Year: 2010

Over a period of 7 consecutive breeding seasons (1998-2005), based on 734 foaling records of Thoroughbred stud farms, the incidence of dystocia and veterinary intervention for removal of fetal membrane was recorded to be 3.14% and 4.9%, respectively. The occurrence of other peripartum reproductive disorder was uncommon.

Sharma S.,Civil Veterinary Hospital | Morel M.D.,Aberystwyth University | Dhaliwal G.S.,Guru Angad Dev Veterinary and Animal Sciences University
Theriogenology | Year: 2010

Decreased reproductive performance due to summer stress is a well known phenomenon in farm livestock. Whether this occurs in the mare and specifically how this might affect postpartum reproductive activity and performance, especially at Foal Heat (FH), is unknown. This study, therefore, aims to investigate this and the factors that might affect postpartum reproductive activity. Reproductive records of 228 Thoroughbred mares (694 mare years) bred in subtropical north-western India were retrospectively analysed. Overt oestrous activity occurred within 21 d postpartum in 92.94% (645/694) of mares. Significantly (p < 0.001) more April foaling mares (97.37%, 185/190) expressed postpartum oestrous activity than those foaling in January (83.61%; 51/61) and February (88.49; 123/ 139). Similarly significantly (p < 0.01) fewer multiparous mares failed to demonstrate oestrous activity than primiparous mares (6.12% vs.15.07%; 38/621 vs. 11/73, respectively). 190 of these 694 mares were additionally monitored to confirm ovulation; in these mares onset of FH (oestrus plus confirmed ovulation) occurred 8.42 ± 0.17 d and first ovulation 13.64 ± 0.20 d postpartum. Month, stud farm, year, and parity did not affect interval from parturition to FH onset or to first ovulation; or FH onset to ovulation. In FH bred mares Day 16 pregnancy rate and overall foaling rate were 53.76% (100/186) and 46.24% (86/186) respectively and were similar to those of mares bred later postpartum. FH pregnancy rates were not affected by stud, season, month, year, number of matings, or day of ovulation but were significantly (p < 0.008) lowered by increasing mare age. Significantly (p < 0.01) lower Day 16 pregnancy rates were observed in uterine treated mares compared to untreated mares (31.09% vs. 57.96%; 9/29 vs. 91/157, respectively), this difference was not evident during the rest of pregnancy. In conclusion, postpartum reproductive and ovarian activity appears to be affected by environment, i.e., delayed in subtropical kept Thoroughbred mares compared to those kept in temperate climates. However, resulting reproductive performance at FH and the factors affecting postpartum reproductive activity are similar. © 2010 Elsevier Inc. All rights reserved.

Sharma S.K.,Guru Angad Dev Veterinary and Animal Sciences University | Sharma S.K.,Civil Veterinary Hospital
Indian Journal of Animal Sciences | Year: 2015

The pharmacokinetics and urinary excretion of pazufloxacin was investigated in buffalo calves following a single subcutaneous administration (5 mg/kg b.wt.). Pharmacokinetic analysis of disposition data indicated that subcutaneous administration data were best described by 1-compartment open model. The peak plasma levels of pazufloxacin were 1.12±0.05 μg/ml at 45 min and the drug was detected up to 16 h. The absorption half-life and elimination half-life were 0.26±0.04 h and 3.01±0.18h, respectively. The apparent volume of distribution and total body clearance were 2.96±0.20 L/kg and 0.67±0.02 L/kg/h, respectively. The urinary excretion of pazufloxacin in 24 h was 23.8±2.30 % of total administrated dose. From the data of surrogate markers (AUC/MIC, Cmax/MIC), it was determined in the buffalo calves that when administered by the subcutaneous route at 5 mg/kg, pazufloxacin is likely to be effective against bacterial isolates with MIC ≤ 0.05 μg/ml. © 2015 Indian Journal of Animal Sciences.

Sharma S.,Civil Veterinary Hospital | Davies Morel M.C.G.,Aberystwyth University | Dhaliwal G.S.,Guru Angad Dev Veterinary and Animal Sciences University | Dadarwal D.,Guru Angad Dev Veterinary and Animal Sciences University
Reproduction in Domestic Animals | Year: 2010

Ultrasonographic pregnancy records of 195 mares from six Thoroughbred stud farms, over a period of 7 years were retrospectively analysed to assess the effect of various factors on embryonic vesicle (EV) fixation pattern and pregnancy outcome. Of the total of 746 pregnancies analysed, significantly (p < 0.01) more EV fixations were evident in the right uterine horn than in the left (53.35% vs 46.65% respectively). There was no significant effect of either, the side of ovulation, or age of the mare, on the side of EV fixation. However, EV fixation, was significantly (p < 0.001) more likely to occur in the right uterine horn in maiden and barren mares (65.75% vs 57.45% respectively). The age and reproductive status of the mare as well as foal heat breeding failed to demonstrate a consistent effect on pregnancy loss relative to the side of EV fixation. In lactating and foal heat bred mares, EVs were significantly (p < 0.0001) more frequently established in the contralateral horn to the one from which the mare delivered her most recent foal. In lactating mares, significantly (p < 0.05) higher embryonic and pregnancy losses were observed in the ipsilateral horn. In conclusion, (a) side of EV fixation was (i) independent of the side of ovulation and mare age (ii) significantly (p < 0.001) affected by reproductive status, (b) neither age of mare nor reproductive status had any effect on pregnancy loss rates relative to the side of EV fixation and (c) in lactating mares the EV had a greater chance of fixation and survival in the horn contralateral to the one from which the mare delivered her most recent foal. © 2009 Blackwell Verlag GmbH.

Sharma S.,Civil Veterinary Hospital | Dhaliwal G.S.,Guru Angad Dev Veterinary and Animal Sciences University | Dadarwal D.,Guru Angad Dev Veterinary and Animal Sciences University
Animal Reproduction Science | Year: 2010

Service records of 253 mares (1181 mare-years) spanning over 7 consecutive years, from nine organized Thoroughbred stud farms, situated in the subtropical northwestern India were retrospectively analyzed to assess their reproductive performance. The overall per cycle pregnancy rate at Day 16 and overall foaling rates were 50.30% and 68.95%, respectively, and were significantly higher in mares aged 3-7 years than ≥18 years old mares. The late embryonic losses (9.86%) that occurred between Days 16 and 39 post-ovulation contributed more than 50% of the overall detected pregnancy losses (19.11%). The overall percent detected pregnancy losses were lower in mares at ages 3-7 years compared to those at ages ≥18 years (14.78% vs. 46.43%, respectively; P < 0.0001). Chronic barren and habitual aborter mares tended to affect reproductive efficiency of mares. Fifty percent of the mares that experienced ≥2 consecutive abortions or barren years, again stayed aborted or barren in the next seasons, respectively. No effect of numbers of matings per oestrus was observed on overall fertility. Neither the induction of oestrus nor ovulation by exogenous hormonal treatment had any effect on most of the analyzed reproductive parameters. Regarding breeding month or years, the reproductive efficiency did not differ significantly. The incidence of multiple pregnancies was 5.40% and percent late embryonic loses were higher (P = 0.0016) in twin (21.98%) than singleton (8.64%) pregnancies. In conclusion, comparatively lower fertility rates were recorded in Thoroughbred mares bred under Indian subtropical climatic conditions than those reported from temperate regions that might be due to difference in breeding management rather than prevailing environment. © 2009 Elsevier B.V. All rights reserved.

Ghuman S.P.S.,Guru Angad Dev Veterinary and Animal Sciences University | Honparkhe M.,Guru Angad Dev Veterinary and Animal Sciences University | Singh J.,Guru Angad Dev Veterinary and Animal Sciences University | Dhami D.S.,Guru Angad Dev Veterinary and Animal Sciences University | And 4 more authors.
Indian Journal of Animal Sciences | Year: 2012

The objective of present study was to elucidate the efficacy of 3 estrus synchronization regimens for optimizing fertility in lactating anestrous buffaloes. Regimen1 (9, GPG), buffaloes were administered (i/m) gonadotropin releasing hormone (GnRH, 0.02 mg) on day 0 and 9, and prostaglandin F 2α (PGF 2α, 500μg cloprostenol sodium) on day 7; regimen 2 (17, GPG+CIDR), in addition to regimen 1, buffaloes were inserted per-vaginally a controlled internal drug release (CIDR, 1.38g progesterone) device for 7 days (day 0-7); regimen 3 (14, GP-hCG), in this regimen, the second- GnRH of the GPG regimen was replaced by human chorionic gonadotropin (hCG, 3000 IU, i/m). Artificial insemination was carried out on days 10 and 11 at 24 h interval. Buffaloes failing to conceive and returning to estrus were again inseminated at their spontaneous estrus. Subsequent to first-GnRH, with or without CIDR device, a good synchrony in the stage of estrous cycle on day 7 was evident as the diameter of largest follicles was not less than 10 mm and was similar between regimens. On day 10, the diameter of largest follicle was more in buffaloes synchronized with CIDR. Buffaloes administered a CIDR device exhibited better estrus behaviour at 48 (day 9) and 72 (day 10) h after CIDR withdrawal compared to controls (GPG). First service conception rate and total % of buffaloes conceived were higher in the buffaloes of GPG+CIDR regimen compared to other regimens. Treatment with CIDR withdrawal had no additional beneficial impact on plasma estradiol at induced-estrus. The body condition score, lactation status, thyroid hormone status and blood biochemical (glucose, total cholesterol, triglycerides, total proteins, creatinine and blood urea nitrogen) profiles were similar between buffaloes of various regimens. In brief, GPG+CIDR based synchronization regimen followed by AI at 72 h and 96 h after CIDR withdrawal is most suitable for optimizing the fertility status of lactating anestrous buffaloes.

Sharma S.K.,Guru Angad Dev Veterinary and Animal Sciences University | Aditi,Guru Angad Dev Veterinary and Animal Sciences University | Aditi,Civil Veterinary Hospital | Haq S.A.U.,Guru Angad Dev Veterinary and Animal Sciences University
Indian Journal of Animal Sciences | Year: 2014

The pharmacokinetics of pazufloxacin was studied in healthy and febrile buffalo calves (5 mg/kg, IV). The fever was induced with Escherichia coli lipopolysaccharide. The drug concentration in plasma was detected by HPLC method.At 2.5 min the concentration of pazufloxacin in healthy and febrile animals were 17.8 0.6 -g/ml and 15.4-0.5 mg/ml,respectively and drug was detected up to 16 h. The distribution half-life of pazufloxacin increased from 0.09-0.01 h in healthy animals to 0.16-0.01 h in febrile animals. Drug distribution was altered by fever as febrile animals showed higher volume of distribution (1.35 0.09 L/kg) higher than normal animal (1.03-0.06 L/kg). Total body clearances in healthy and febrile animals were 539.7-28.3 and 510.6-18.2 ml/kg/h, respectively. To maintain minimum therapeutic concentration of 0.1 -g/ml, a satisfactory dosage regimen of pazufloxacin in healthy and febrile buffalo calves would be 4.7 mg/kg and 4 mg/kg body weight, respectively,to be repeated at 12 h intervals.

Manzoor S.,Inside Civil Veterinary Hospital | Hussain Z.,Civil Veterinary Hospital | Rahman S.U.,University of Agriculture at Faisalabad | Hussain I.,University of Agriculture at Faisalabad
British Poultry Science | Year: 2013

1. Domestic fowl and free-living birds were examined for the presence or absence of antibodies against hydropericardium syndrome (HPS) using an indirect haemagglutination assay. 2. Two-hundred and eighty serum samples of commercial (45 broilers, 20 adult layers and 15 Fayoumi fowl) and wild birds, including 65 peafowl, 45 pigeons, 10 crows, 30 house sparrows, 10 doves, 15 ducks, 10 parrots and 15 guinea fowl, were collected and examined. 3. The percentage of HPS-positive serum samples was 80% in house crows, 78% in pigeons, 7% in house sparrows and 6% in peafowl. 4. The sera obtained from parrots, doves, ducks and guinea fowl were all negative. 5. This study suggests that crows and pigeons could be carriers of the HPS agent. © 2013 Copyright © 2013 British Poultry Science Ltd.

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