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Yang J.,Capital Medical University | Wang G.,Civil Aviation General Hospital | Gao C.,Capital Medical University | Shao G.,Shanghai Minxing Wujing Hospital | Kang N.,Capital Medical University
Life Sciences | Year: 2013

Aims: To evaluate the effects of hyperbaric oxygen (HBO) therapy on MMP-2 and MMP-9 expression and spinal cord edema after acute spinal cord injury (SCI). Main methods: Ninety-six healthy adult Sprague - Dawley rats were randomly divided into 4 groups: sham, sham + HBO, SCI, and SCI + HBO. Each group was subdivided into 4 subgroups of 6 rats each: 24 h, 48 h, 72 h, and 5 d post-injury. The expression levels of matrix metalloproteinase-2 (MMP-2), MMP-9, interleukin (IL-6), and vascular endothelial growth factor (VEGF) were measured using ELISA. The water content of the spinal cord was also measured by Elliot equation. Key finding: MMP-2 and MMP-9 levels and spinal cord water content increased significantly in the SCI group compared to those in the sham and sham + HBO groups at different time points after SCI (P < 0.01). The MMP-2 level was significantly different between the SCI and SCI + HBO groups at 72 h after SCI (P < 0.05), while the MMP-9 level was significantly different at 48 h, 72 h, and 5 d (P < 0.05). The water content of the spinal cord was significantly higher in the SCI group at 5 d after SCI (P < 0. 01). MMP-2 (P < 0.05) and MMP-9 (P < 0.01) levels were positively correlated with spinal cord water content. Significance: HBO reduced SCI-induced spinal cord edema, stabilized the blood-spinal cord barrier, and promoted recovery of neuronal function by down regulating the expression of IL-6, MMP-2, and MMP-9 and up regulating the expression of VEGF. © 2013 Elsevier Inc. All rights reserved. Source


Jing C.-J.,Tsinghua University | Ye J.-Q.,Civil Aviation General Hospital
International Journal of Ophthalmology | Year: 2011

Age-related macular degeneration (AMD) is the chief cause of severe and irreversible loss of vision and blindness for elderly people, and it severely affects the elderly and their family members' physical and mental health. Based on the analysis of clinical features and pathogenesis of AMD, the latest clinical applications of AMD treatments are reviewed, and the adaptability of various treatments and their limitations are elaborated and explained. Source


Zhang H.-L.,Civil Aviation General Hospital
International Eye Science | Year: 2016

AIM: To investigate and analyze the prevalence and the influencing factors on retinal arteriosclerosis in civil aviators of different ages. METHODS: Two thousand seven hundred and seventy-eight commissioned civil aviators who received medical exa mination in Civil Aviation General Hospital from July 2014 to July 2015 were randomly divided into three groups: group A (1311 aviators aged 22-39), group B (618 aviators age 40-49), group C (849 aviators age 50-59). Aviators over 40 years old, were divided into two groups: group with retinal atherosclerosis and group without retinal atherosclerosis according to the results of fundus exa mination. Medical exa mination data of the aviators were analyzed. RESULTS: Of 2 778 aviators, 334 (12.02%) were detected with retinal arteriosclerosis, among which 318 aviators were classified as grade I, and 16 aviators as grade II. The retinal arteriosclerosis prevalence of group A, B, and C increased with age, and the difference was statistically significant (P<0.05). Biochemical tests showed that the prevalence of hypertension, hyperlipidemia, high fasting blood glucose and overweight increased in group with retinal arteriosclerosis compared with that in group without retinal arteriosclerosis, and the difference was statistically significant (P<0.05). CONCLUSION: The prevalence of retinal arteriosclerosis in commissioned civil aviators was 12.02%, and most of the retinal arteriosclerosis was classified as grade I. In aviators over 40 years old, hypertension, hyperlipidemia, high fasting blood glucose and overweight were important factors in the development of retinal arteriosclerosis. Copyright 2016 by the IJO Press. Source


Yang J.,Capital Medical University | Liu X.,Capital Medical University | Zhou Y.,Shenyang Medical College | Wang G.,Civil Aviation General Hospital | And 2 more authors.
Spine | Year: 2013

STUDY DESIGN.: We presented an insight into the effect of hyperbaric oxygen (HBO) on spinal cord injury (SCI), aiming to uncover the dynamics of high-mobility group protein B1 (HMGB1) and nuclear factor κB (NF-κB) after HBO intervention in rats with acute SCI. OBJECTIVE.: Prognosis of SCI is directly linked with the control of secondary injury, in which the inflammatory response plays a leading role. HBO therapy can reduce this secondary damage to the spinal cord. We used an animal model to characterize the therapeutic effect of HBO on SCI. SUMMARY OF BACKGROUND DATA.: A growing number of studies have confirmed that HBO has gradually become an indispensable element after SCI in reducing neurological disorders, and improving the physical function and quality of life of patients. The role of HBO in the process of HMGB1/NF-κB- related secondary inflammatory responses in SCI has yet to be characterized. METHODS.: Rats were randomly categorized into sham, sham + HBO, SCI, and SCI + HBO groups. The expression levels of HMGB1 and NF-κB were measured at days 1, 3, 7, and 14 after SCI. RESULTS.: After SCI, significant increases in mRNA and protein expression were observed for both HMGB1 and NF-κB (P< 0.01) compared with sham group. HMGB1 mRNA and protein expression levels were decreased after HBO intervention. The decreases were significant at days 7 and 14 (P< 0.05) post-HBO. In the SCI + HBO group, the significant decreases in NF-κB mRNA and protein expression levels were also observed at days 3, 7, and 14 (P< 0.05). After HBO intervention, a significant increase was seen in the Basso, Beattie, and Bresnahan score at days 7 and 14 (P< 0.05). CONCLUSION.: HBO intervention may reduce the secondary damage of SCI caused by inflammatory responses via downregulating the expression of HMGB1/NF-κB, and promoting the repair of neurological function. Copyright © 2013 Lippincott Williams &Wilkins. Source


Wang J.,Capital Medical University | Wang P.,Civil Aviation General Hospital | Wang X.,Capital Medical University | Zheng Y.,Peking University | And 2 more authors.
JAMA Internal Medicine | Year: 2014

IMPORTANCE: Appropriate antibiotic use is a key strategy to control antibacterial resistance. The first step in achieving this is to identify the major problems in antibiotic prescription in health care facilities, especially in primary health care settings, which is where most patients receive medical care. OBJECTIVE: To identify current patterns of antibiotic use and explore the reasons for inappropriate prescription in primary health care settings in China. DESIGN, SETTING, AND PARTICIPANTS: A total of 48 primary health care facilities in China were randomly selected from 6 provinces at various levels of economic development. Data for the years 2009 through 2011 from 39 qualifying facilities (23 city and 16 rural primary health care centers) were analyzed retrospectively. The study sample consisted of prescription records for 7311 outpatient visits and 2888 inpatient hospitalizations. MAIN OUTCOMES AND MEASURES: General health center information, drug usage, disease diagnoses, and antibiotic use by outpatients and inpatients were surveyed. Cases of inappropriate antibiotic prescription were identified. RESULTS: Most staff in the primary health care facilities had less than a college degree, and the medical staff consisted primarily of physician assistants, assistant pharmacists, nurses, and nursing assistants. The median (range) governmental contribution to each facility was 34.0% (3.6%-92.5%) of total revenue. The facilities prescribed a median (range) of 28 (8-111) types of antibiotics, including 34 (10-115) individual agents. Antibiotics were included in 52.9% of the outpatient visit prescription records: of these, only 39.4%were prescribed properly. Of the inpatients, 77.5%received antibiotic therapy: of these, only 24.6%were prescribed properly. Antibiotics were prescribed for 78.0% of colds and 93.5%of cases of acute bronchitis. Of the antibiotic prescriptions, 28.0%contained cephalosporins and 15.7% fluoroquinolones. A total of 55.0%of the antibiotic prescriptions were for antibiotic combination therapy with 2 or more agents. In nonsurgical inpatients in cities, the mean (SD) duration of antibiotic therapy was 10.1 (7.8) days. Of the surgical patients, 98.0%received antibiotics, with 63.8% of these prescriptions for prophylaxis. CONCLUSIONS AND RELEVANCE: Antibiotics are frequently prescribed in Chinese primary health care facilities, and a large proportion of these prescriptions are inappropriate. Frequent and inappropriate use of antibiotics in primary health care settings in China is a serious problem that likely contributes to antimicrobial resistance worldwide. Copyright 2014 American Medical Association. All rights reserved. Source

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