Abstract: Reducing a barrier that generally hinders the easy generation of new molecules, a team led by City College of New York chemist Mahesh K. Lakshman has devised a method to cleave generally inert bonds to allow the formation of new ones. The study is the cover story in the journal ACS Catalysis published by the American Chemical Society. "Saturated carbon-hydrogen bonds in organic compounds are considered relatively inert and generally difficult to break in order to make other bonds, leading to new molecules," explained Lakshman, professor of chemistry in City College's Division of Science. However, Lakshman and his colleagues demonstrated a method for accomplishing cleavage of carbon-hydrogen bonds and subsequent formation of carbon-nitrogen bonds. Many of the ensuing new molecules bear structural similarities to the class of dideoxynucleosides, which are used as antiviral drugs. "Thus, this research can provide more direct access to novel pharmaceutical entities," said Lakshman, whose research thrust is organic synthesis at the chemistry-biology interface. ### His research team included fellow chemists Manish K. Singh (CCNY and the Graduate Center, CUNY, now a postdoctoral associate at UNC, Chapel Hill), Hari K. Akula (CCNY, the Graduate Center, Ph.D. student), Sakilam Satishkumar (CCNY, postdoctoral associate) and Dr. Lothar Stahl (University of North Dakota). About City College of New York Since 1847, The City College of New York has provided low-cost, high-quality education for New Yorkers in a wide variety of disciplines. More than 15,000 students pursue undergraduate and graduate degrees in the College of Liberal Arts and Science; Bernard and Anne Spitzer School of Architecture; School of Education; Grove School of Engineering; Sophie Davis Biomedical Education/CUNY School of Medicine; and the Colin Powell School for Civic and Global Leadership. U.S. News, Princeton Review and Forbes all rank City College among the best colleges and universities in the United States. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
The neuroscience community is saluting the creation of a "Golden Window" for deep brain imaging by researchers at The City College of New York led by biomedical engineer Lingyan Shi. This is a first for brain imaging, said Shi, a research associate in City College's Institute for Ultrafast Spectroscopy and Lasers, and the biology department. The breakthrough holds promise for the noninvasive study of the brain and breasts in greater detail than possible today. Working with Distinguished Professor of Physics Robert R. Alfano and Adrian Rodriguez-Contreras, an assistant professor of biology, Shi's team proved theoretically and experimentally that deep imaging of the brain is possible using light at wavelength 1600-1880nm (nanometer). This is dubbed the "Golden Window" for imaging. In the past, near-infrared (NIR) radiation has been employed using one and two-photon fluorescence imaging at wavelengths 650-950 nm for deep brain imaging. This is known as optical window 1. Shi, who earned a Ph.D. in biomedical engineering from CCNY's Grove School of Engineering in 2014, said the current research introduces three new optical windows in the NIR region. And she demonstrates the windows' potential for deeper brain tissue imaging due to the reduction of scattering that causes blurring. Published by the Journal of Biophotonics, her study sheds light on the development of next generation of microscopy imaging technique, in which the "Golden Window" may be utilized for high resolution deeper brain imaging. The next step in the research is in vivo imaging in mice using Golden Window wavelength light.
Kalyva E.,City College
Research in Autism Spectrum Disorders
Individuals with autism spectrum disorders (ASD) experience sexuality issues, but there are very few studies looking at sexuality and autism. The present study aims to examine teachers' perceptions of sexual behaviors of 56 children with low functioning autism (LFA) and 20 children with high functioning autism (HFA) or Asperger Syndrome (AS). Teachers perceived children with LFA as exhibiting less socially acceptable behaviors, as possessing lessened awareness of privacy related rules, and as having more limited knowledge of typical sexual responses and behaviors in comparison to children with HFA or AS. However, teachers expressed more concerns for children with HFA or AS. These findings should be taken into consideration when designing intervention programs targeting sexuality of individuals with ASD. © 2009 Elsevier Ltd. All rights reserved. Source
News Article | October 27, 2015
While most who know her would describe Bevy Smith as a woman about town, the radio host and TV personality admits that she rarely leaves Harlem. Born and raised in the northern Manhattan neighborhood, Smith credits growing up uptown with everything from her career courage to her love of a stiletto heel and wrap dress. When she left a thriving career—and big paycheck—doing fashion ad sales for magazines to become an entertainer, Smith knew she could do it. And this was from day one, before she landed countless media appearances, a three-season Bravo series (Fashion Queens) and her brand-new show, Bevelations, on Sirius Radio. What gave her all that confidence? Harlem, of course. Here, Smith talks about the neighborhood's gravitational pull. When did you fall in love with Harlem? Since I was a kid I knew it was one of the great places of Manhattan. And as an adult, I can really appreciate how the community is rich with a legacy that belongs to me and mine. When I’m on Lenox Avenue, I’m on the same avenue that Langston Hughes and Zora Neale Hurston walked. It's where Malcolm X became a magical orator. I can stand on 140th Street, where Sammy Davis Jr. used to tap dance on the corner for money. Then, I can get on the subway at 145th Street, and two stops later, I’m in midtown, on 59th Street—it’s a no-brainer that it’s wonderful. Imagine you could only spend 24 hours ever again in Harlem. What are you doing that day? I would go to the Schomburg, then to the block where I grew up on 150th and 8th Avenue. Next, I’d hang out with neighborhood kids at the public pool down the block from my house—the pool is next to the projects. It’s not fancy and the kids love it; it’s a real reminder that happiness doesn’t have to mean money. Afterwards, I would go to the Apollo—hopefully it’s a Wednesday night, so I can see Amateur Night. Harlem is all about peacocking, and that’s how it has influenced my style. Then [Marcus Samuelsson’s restaurant] Red Rooster. I would have to reopen the [recently closed] Lenox Lounge so I could head over there around 2 o’clock in the morning. There are so many things I would reopen, including M&Gs, where I’d play the jukebox and have scrambled eggs, cheese, salmon croquettes and grits at like 5 a.m. Lunch would be barbecue shrimp and a mai tai at Sylvia’s. I’d walk through St. Nicholas Park and take the stairs three at a time. I would definitely go to the vista of City College where you can overlook all of Harlem and take the river walk at 125th Street. Other than your love of Harlem as a place to hang out, how has it affected the rest of your life? Harlem is all about peacocking, and that’s how it has influenced my style. I love a bright color and a body-con dress. This place on Lenox Avenue, The Cove—there you’ll see women enjoying themselves dancing and having fun. These are women who maybe mainstream society wouldn’t deem attractive. But they are all that, with this real joy and confidence that inspires me. It’s quite interesting: People try to compare Harlem to Brooklyn, and you can’t compare the two. Brooklyn is a borough, Harlem is a neighborhood. Harlem folks have such a leg up from people from outer boroughs because we are a part of Manhattan, which is the epicenter of the world. And I’m already here—I didn’t have to go anywhere to make my dreams come true. How does that translate to your work? Everything I do professionally is connected to who I am as a black woman from this vibrant community. When I host a Dinner with Bevy (an invitation-only event where I connect people from art, entertainment, fashion and philanthropy), it’s what I saw barmaids do as a kid—entertaining the guests, remembering their cocktail, introducing them to people who I think might be interested in each other, like sitting Nelson George next to Misty Copeland and two years later he makes a documentary on her [A Ballerina’s Tale]. That’s just being a barmaid at the Dunbar on 150th Street! My podcast, Bevy Says, is all about women’s empowerment and finding the power to express who you are. And that is all Harlem women, having an authentic voice and a swagger and an approach to life that is fearless. It’s about being an explorer and experimenter.
The nitrogen-vacancy (NV) center is an optically active defect in diamond comprising a nitrogen atom and an adjacent vacancy, replacing carbon atoms in the diamond lattice. This defect has electrons that are capable of storing quantum information. To utilize this special property for quantum computation, it is required to create a network of interacting NV centers. The research so far has focused on using photons emitted by the NV centers to create this interaction under a special low temperature environment. In a complementary approach the research team at City College in collaboration with researchers at the Australian National University (ANU) in Canberra are envisioning an electron-transport-based interaction that is realizable in ambient conditions. In one of the key experiments reported a focused green laser beam was used to remove the electrons from the NV centers, which later diffused radially in the diamond. A red laser scan was used to image NV centers that trapped these diffused charges as far as 30 microns. The team exploited the difference in luminescence intensities of the NV centers with and without the electron to create a map of the trapped carriers. "These are very promising initial results" said lead author Dr. Harishankar Jayakumar, a postdoctoral fellow at the Meriles group. Other key contributors are CCNY team members Dr. Siddharth Dhomkar, and graduate student Jacob Henshaw, as well as Dr. Marcus Doherty and Prof. Neil Manson at ANU. The article appearing in the journal Nature Communications also discusses in detail the complex interactions of the charge carriers with other defects in diamond, uncovered by this technique. The National Science Foundation supported the research. More information: Harishankar Jayakumar et al. Optical patterning of trapped charge in nitrogen-doped diamond, Nature Communications (2016). DOI: 10.1038/ncomms12660