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Ter-Ovanesov M.D.,Russian National Research Medical University | Fatuev O.E.,City Clinical Hospital No 40 | Aksarin A.A.,Regional Oncology Dispensary | Baksiyan G.A.,City Clinical Hospital No 40 | And 3 more authors.
Voprosy Onkologii | Year: 2015

Patients with resectable non-small cell lung cancer have a chance to reach a 5-year survival rates ranging from 70% or more for stage IA and 20% for stage IIIA. These figures have remained stable for the past 20 years. Moreover, the inability to improve long-term outcomes is generally determined by a fatal disease progression due to the emergence of distant metastases or local recurrence often in combination with systemic progression process. Thus the use of chemotherapy both in neoadjuvant and adjuvant regimens has stimulated for a long time the search for the optimal scheme and treatment options. This article presents a critical analysis of the current state of the problem of neoadjuvant and adjuvant chemotherapy as well as chemoradiotherapy in order to optimize the tactics of combined treatment of these groups of patients. Source


Ter-Ovanesov M.D.,Russian National Research Medical University | Fatuev O.E.,City Clinical Hospital No 40 | Gaboyan A.S.,City Clinical Hospital No 40 | Levitsky A.V.,City Clinical Hospital No 40 | And 3 more authors.
Voprosy Onkologii | Year: 2015

Despite the modern achievements of different methods of treatment, primarily surgical, with recognized need of standardization of lymphadenectomy D2, gastric cancer still remains one of the most difficult malignant tumors characterized by high rates of one-year mortality and low rates of survival that are far from satisfactory. According to experts such unsatisfactory results are determined by a combination of factors: the characteristics of ill people, their functional status, age characteristics, the prevalence of the disease at diagnosis with the presence of systemic micrometastases, resistance to treatment, etc. Moreover, a factor of resistance to treatment i.e. to existing schemes and methods is mostly a key one that determines low levels of long-term survival. Source

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