Astudillo-De La Vega H.,Hospital Of Cardiologia |
Gaceta Mexicana de Oncologia | Year: 2010
Chemoresistance is a specific resistance acquired by any cell to the action of certain chemicals. Most of the cancer patients, who initially respond to chemotherapy, will have a progression or recurrence sometimes after treatment. Multi-drug resistance (MDR) is the principal mechanism by which many cancers develop resistance to chemotherapy drugs. Genetic and resistance bacteria research plus DNA recombinant techniques had help to understand the resistance mechanism of cancer cells. The study of cells genetic mutation that develops resistance, have define two types of resistance: an intrinsic and acquire. The expression of MDR1 gene in tumors with intrinsic and acquire resistance, suggests his participation into the mechanism of chemoresistance. The cellular phenotype of MDR is a consequence of a genetic abnormality that increased proteins production, consistently inhibits the action of some drugs. For example slow growing cells could be resistant to chemotherapy that specifically works into that enzyme. The epothilones A and B can inhibit P-glycoprotein- who is responsible of drug resistance. Azaepothilone B (ixabepilone) belongs to a novel class of drugs that stops cell division because they are nontaxane microtubule-stabilizing agent.
Martinez-Mier G.,Corporativo San Gabriel Alacio Perez 928 |
Canas-Acar J.,Cirugia Pediatrica |
Gomez-Dorantes S.,Pediatria Oncologica |
Santos-Aguilar U.,Cirugia |
And 2 more authors.
Cirugia y Cirujanos | Year: 2012
Background: mesenchymal hamartoma of the liver is a rare benign liver tumor in children, usually arising from the right liver lobe and represents about 5 to 6% of all primary hepatic tumors. Complete surgical resection of the tumor is curative. Clinical case: a 30 months old male presented with epigastrium abdominal pain and a palpable mass over a period of two days with no other symptom. The mass was excised completely. Postoperatively the patient recovered with an uneventful course and was discharge 13 days following surgery. All microscopic findings were consistent with the diagnosis of mesenchymal hamartoma of the liver. Conclusions: approximately 75% of mesenchymal hamartoma of the liver occur in the right lobe of the liver. Several diagnostic considerations should be elucidated to differentiate these type of tumors in the left lobe from other benign liver tumors. Sometimes a multidisciplinary approach is necessary to complete a successful complete surgical excision. Our case exemplifies a rare entity in a rare location, an adequate treatment in a third level reference hospital setting.
Blugerman G.,Clinica BandS |
Schavelzon D.,Clinica BandS |
D'Angelo S.,Clinica BandS |
D'Angelo W.,Cirugia |
Prensa Medica Argentina | Year: 2010
Introduction: The surgical dermoabration consists in the removal of the superficial dermis through out an abrasive process with sandpaper and/or diamonds drills that intends the attenuation of facial wrinkles, acne sequels and skin hiperpigmentation. The platelets rich plasma (PRP) is an autologous, nontoxic, nonalergenic product obtained from the patient's blood centrifugation, it contains 95% of platelet and it can be used topically over the post dermoabration wound and it accelerates the repair and healing of the wounds. Material and method: We treated 32 patients (12 male and 20 female) of 38 years average: 15 with acne sequels, 13 with facial wrinkles and 4 because of facial rejuvenation. We did the surgical dermoabration with local tumescent anesthesia infiltration using sandpaper and/or diamonds drill. The PRP is obtained from the patient's autologous venous blood centrifugation. Results: All the patients had satisfactory results with less scar formation and a faster reepitelization process Conclusion: In cosmetic and esthetic medicine there are many ways of uses the PRP. This paper shows our experience in the topical use of PRP in patients submitted to a surgical dermoabration. It's observed that when placing PRP in the wound the process of reepitelization of the wound is accelerated, allowing a better healing which is noticed as a shorter recovery time, avoiding infections and hematomas. It has not contraindications because is an autologous, nontoxic, nonalergenic product obtained by the patient blood centrifugation.
Gonzalez-Gonzalez M.,University of Salamanca |
Montero J.A.A.,CirugIa |
Fernandez L.M.G.,CirugIa |
Bengoechea O.,Hospital Universitario Of Salamanca Iibsal |
And 4 more authors.
Cancer Genomics and Proteomics | Year: 2013
Sporadic colorectal cancer (sCRC) is one of the most frequent types of cancer in Europe. Despite understanding of its tumorigenesis, the metastatic process is not yet clear. In this article, we review the most significant genetic and proteomic advances that have been made in regards to research of the sCRC metastatic process, and the new biomarkers that are able to predict disease prognosis or response to treatments, in order to define personalized medicine.
PubMed | Cirugia
Type: Letter | Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva | Year: 2016
The authors present a case of early hiatal hernia (HH), 30 days after surgery, that recurred a week after. Our purpose in this case report is to discuss briefly the potential cause and to enhance the importance of CT.