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Ghemigian A.,National University of Pharmacy | Carsote M.,National University of Pharmacy | Terzea D.,Ciparhon National Institute Of Endocrinology | Capatina C.,National University of Pharmacy
Romanian Journal of Legal Medicine | Year: 2015

Introduction. Primary osteoporosis in men is significantly less frequent than in women but is similarly associated with an increased risk of fractures (including fragility fractures i.e.fractures that occurr without any causal trauma). Vertebrae are common sites for fragility fractures which can be oligo-or completely asymptomatic. Case report. We present the case of a man diagnosed after a traumatic event with both severe spine fractures and agerelated osteoporosis. A 65-year non-smoking Caucasian man with negative medical history suffered a spine trauma during his work in constructions. Fractures at T12 and L1 were diagnosed and surgically managed (T12 laminectomy and T12-L1 bilateral titanium osteosynthesis). Osteoporosis was also confirmed by DXA osteodensitometry. He received antiosteoporotic treatment (bisphosphonates, vitamin D supplementation) but at the 1 year-follow-up visit a new fragility fracture (T7 vertebra) was diagnosed. The occurrence of fragility fractures despite active antiosteoporotic treatment raised significant dillemas related to the individual contributions of osteoporosis and trauma to the initial, apparently posttraumatic vertebral fractures. Conclusion. In the presence of confirmed osteoporosis (a condition with increased risk of spontaneous vertebral fractures, frequently asymptomatic) it is very difficult to correctly discern the contribution of a spinal trauma to the etiopathogenesis of vertebral fractures. © 2015 Romanian Society of Legal Medicine.

Gheorghisan-Galateanu A.A.,Carol Davila University of Medicine and Pharmacy | Gheorghisan-Galateanu A.A.,Ciparhon National Institute Of Endocrinology
BMC Research Notes | Year: 2014

Background: Leydig cell tumors are the most common non-germ cell gonadal tumors with apparent increased incidence in the last few years. They are usually benign tumors. We report a case of Leydig cell tumor of testis in a patient presenting atypical features. Case presentation: A 29-year-old Caucasian man, born with right cryptorchidism, corrected without medical treatment before the age of two years, was diagnosed with Leydig cell tumor. Two years after diagnosis was identified moderately elevated estradiol serum level, in the context of a significant overweight, hormonal changes which had maintained after unilateral orchiectomy and after the patient's return to normal weight. Four years after unilateral orchiectomy, elevated value of estradiol persisted and subdiaphragmatic micro lymphadenopathy was observed. Conclusions: Despite the favorable evolution of the patient four years after unilateral orchiectomy, long-term follow-up is necessary to exclude recurrence or metastasis to the testis. The endocrine profile and imaging investigations need to be repeated periodically. The changes in the hormonal assay and any new aspects on computed tomography scan can be used as a marker of tumor recurrence and require careful screening and the correct therapeutic decisions. © 2014 Gheorghisan-Galateanu; licensee BioMed Central Ltd.

Miulescu R.D.,Carol Davila University of Medicine and Pharmacy | Miulescu R.D.,Nc Paulescu National Institute Of Diabetes | Margina D.,Carol Davila University of Medicine and Pharmacy | Culman M.,Carol Davila University of Medicine and Pharmacy | And 4 more authors.
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2013

Background and Aims. Previous studies have shown that impaired glucose tolerance is present in patients with pheochromocytoma with a prevalence of 25-75%. The aim of this study was to examine glucose tolerance in 12 patients with pheochromocytoma, before and after medical and surgical treatment. Material and Methods. We evaluated 12 patients aged between 44 and 60 years with confirmed pheochromocytoma. Plasma insulin, fasting blood glucose and 2h glucose levels during the oral glucose tolerance test (OGTT) were measured before and three months after surgical removal of the tumor. Results. Surgical removal of the tumor generated significant changes in plasma and urinary metanephrines (plasma normetanephrine 191.15±13.22 pg/ml after treatment vs. 792.54±86.74 pg/ml at baseline, p<0.0001, plasma metanephrine 86.69±4.48 pg/ml vs. 363.62.±21.69 pg/ml, p<0.0001, urinary normetanephrine 718.54±37.59 μg/day after treatment vs. 1855.77±116.54 μg/day at baseline and urinary metanephrine of 258.31±34.00 μg/day vs. 745.38±65.14 μg/day, p<0.0001) but not in insulin, fasting and 2h glucose levels during OGTT. Conclusion. In our study, the prevalence of impaired glucose tolerance in patients with confirmed pheochromocytoma was 8.33% (1 patient with a previous family history of diabetes). After surgical removal of the tumor, normalization of mean glucose levels of OGTT was not achieved. © 2013 ILEX PUBLISHING HOUSE, Bucharest, Roumania.

Miulescu R.D.,Carol Davila University of Medicine and Pharmacy | Miulescu R.D.,Ncpaulescu National Institute Of Diabetes | Margina D.,Carol Davila University of Medicine and Pharmacy | Sfetea R.C.,Carol Davila University of Medicine and Pharmacy | And 4 more authors.
Romanian Journal of Diabetes, Nutrition and Metabolic Diseases | Year: 2013

Background and Aims. Previous studies have shown that aging is an important risk factor for insulin resistance and type 2 diabetes. The beneficial effects of exercise on glucose metabolism are well known. Our goal was to examine whether physical activity improves insulin levels in older individuals. Material and Methods. Plasma glucose and insulin were measured in fasting state and 2 h after a 75-g oral glucose tolerance test in young lean, sedentary, non-diabetic subjects (n=34, age 25±2 years, body mass index-BMI 24.4±0.7 kg/m2) and older, lean, sedentary, non-diabetic subjects (n=36, age 75±3 years, BMI 24.8±0.4 kg/m2), before and after 8 weeks of aerobic exercise. Training consisted of exercise (such as cycling or fast walking) 5 days/week for approximately 30 min/day. Results. Fasting plasma insulin and 2-h serum insulin levels at baseline were significantly higher in older than young subjects (11.6 μU/ml vs 10.0 μU/ml, p=0.0001, 46.3 μU/mlvs 34.0 μU/ml, p=0.0001). Fasting and 2h plasma insulin levels were reduced after 8 weeks of aerobic exercise in older subjects, with no change in body weight. Conclusion. In our study the hyperinsulinemia associated with aging can be blunted significantly by aerobic exercise in older individuals independent of any changes in body composition. © 2013 ILEX PUBLISHING HOUSE, Bucharest, Roumania.

Gheorghisan-Galateanu A.,Ciparhon National Institute Of Endocrinology | Gheorghisan-Galateanu A.,Carol Davila University of Medicine and Pharmacy | Terzea D.C.,Ciparhon National Institute Of Endocrinology | Terzea D.C.,Carol Davila University of Medicine and Pharmacy | And 5 more authors.
Journal of Ovarian Research | Year: 2013

This study aimed to investigate an unusual case of immature ovarian teratoma with onset of mature glial cells implanted on the contralateral ovary, a challenge in the diagnosis of the second ovarian tumor. We report the case of a 31- yr-old woman, who developed at the age of 16 an immature teratoma in the right ovary that was surgically removed. Six years later mature glial implants were present on the left ovary and six months later at the level of peritoneum that relapsed after other six months. The patient suffered three surgical resections after the initial one. Paraffin sections and immunohistochemical examinations using antibodies against glial and neuronal antigens were performed. In the teratoma, the neuroectodermal tissue expressed Glial fibrillary acidic protein (GFAP), S100 protein, Epithelial membrane antigen (EMA) and Cytokeratin 34 beta E12 (Ck34beta E12), wheares the implants expressed only GFAP and S100 protein. The immature teratoma is the rarest type of ovarian teratomas. Gliomatosis peritonei is an exceptional finding, expecially with onset on the contralaterally ovary. The implant of the mature glial cells has a high risk of relapse, as seen in our case, thus close follow-up of the patient is necessary. © 2013 Gheorghisan-Galateanu et al.; licensee BioMed Central Ltd.

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