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Duderstadt, Germany

Rajasekaran P.,Ruhr University Bochum | Mertmann P.,Ruhr University Bochum | Bibinov N.,Ruhr University Bochum | Wandke D.,CINOGY GmbH | And 3 more authors.
Plasma Processes and Polymers | Year: 2010

The reported dielectric barrier discharge (DBD) source comprises of a ceramic-covered copper electrode, and plasma can be ignited in ambient air with grounded Opposite' electrodes or with objects of high capacitance (e.g., human body), when breakdown conditions are satisfied. Filamentary plasma mode is observed when the same source is operated using grounded opposite electrodes like aluminium plate and phosphate buffered saline solution, and a homogeneous plasma mode when operated on glass. When the source is applied on human body, both homogeneous and filamentary discharges occur simultaneously which cannot be resolved into two separate discharges. Here, we report the characterization of filamentary and homogeneous modes of DBD plasma source using the above mentioned grounded electrodes, by applying optical emission spectroscopy, microphotography and numerical simulation. Averaged plasma parameters like electron velocity distribution function and electron density are determined. Fluxes of nitric oxide, ozone and photons reaching the treated surface are simulated. These fluxes obtained in different discharge modes namely, single-filamentary discharge (discharge ignited in same position), stochastical filamentary discharge and homogeneous discharge are compared to identify their applications in human skin treatment. It is concluded that the fluxes of photons and chemicallyactive particles in the single filamentary mode are the highest but the treated surface area is very small. For treating larger area, the homogeneous DBD is more effective than stochastical filamentary discharge. (Figure Presented) © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Brehmer F.,University of Gottingen | Haenssle H.A.,University of Gottingen | Daeschlein G.,University of Greifswald | Ahmed R.,Institute fur Anwendungsorientierte Forschung und Klinische Studien IFS GmbH | And 6 more authors.
Journal of the European Academy of Dermatology and Venereology | Year: 2015

Background: Cold atmospheric plasma (CAP, i.e. ionized air) is an innovating promising tool in reducing bacteria.Objective: We conducted the first clinical trial with the novel PlasmaDerm® VU-2010 device to assess safety and, as secondary endpoints, efficacy and applicability of 45 s/cm2 cold atmospheric plasma as add-on therapy against chronic venous leg ulcers.Methods: From April 2011 to April 2012, 14 patients were randomized to receive standardized modern wound care (n = 7) or plasma in addition to standard care (n = 7) 3× per week for 8 weeks. The ulcer size was determined weekly (Visitrak®, photodocumentation). Bacterial load (bacterial swabs, contact agar plates) and pain during and between treatments (visual analogue scales) were assessed. Patients and doctors rated the applicability of plasma (questionnaires).Results: The plasma treatment was safe with 2 SAEs and 77 AEs approximately equally distributed among both groups (P = 0.77 and P = 1.0, Fisher's exact test). Two AEs probably related to plasma. Plasma treatment resulted in a significant reduction in lesional bacterial load (P = 0.04, Wilcoxon signed-rank test). A more than 50% ulcer size reduction was noted in 5/7 and 4/7 patients in the standard and plasma groups, respectively, and a greater size reduction occurred in the plasma group (plasma -5.3 cm2, standard: -3.4 cm2) (non-significant, P = 0.42, log-rank test). The only ulcer that closed after 7 weeks received plasma. Patients in the plasma group quoted less pain compared to the control group. The plasma applicability was not rated inferior to standard wound care (P = 0.94, Wilcoxon-Mann-Whitney test). Physicians would recommend (P = 0.06, Wilcoxon-Mann-Whitney test) or repeat (P = 0.08, Wilcoxon-Mann-Whitney test) plasma treatment by trend.Conclusion: Cold atmospheric plasma displays favourable antibacterial effects. We demonstrated that plasma treatment with the PlasmaDerm® VU-2010 device is safe and effective in patients with chronic venous leg ulcers. Thus, larger controlled trials and the development of devices with larger application surfaces are warranted. © 2014 European Academy of Dermatology and Venereology. Source


Helmke A.,HAWK University of Applied Sciences and Arts | Grunig P.,HAWK University of Applied Sciences and Arts | Fritz U.-M.,HAWK University of Applied Sciences and Arts | Wandke D.,CINOGY GmbH | And 3 more authors.
Recent Patents on Anti-Infective Drug Discovery | Year: 2012

The effects of low-temperature plasma treatment on microorganisms typically related to skin diseases are studied qualitatively by the inhibition of growth and viability assays to evaluate the potential for classifying as a prospective antiseptic agent. A variety of microorganisms enveloping gram- negative and gram-positive bacteria as well as one genus of yeast and fungus each were exposed to plasma in vitro. In a comparative approach, two power supplies, both of which produce high voltage pulses yet at different temporal characteristics, are applied for the growth study. While operation with both devices led to growth inhibition of all microbes, the results indicate a superior antimicrobial efficacy for high voltage pulse lengths in the nanosecond scale. Fluorescence assays reveal the efficacy of nanosecond-pulse driven plasma in reducing germ viability. Furthermore, the technical background for patents related to low-temperature plasma technology in the field of plasma medicine is discussed. © 2012 Bentham Science Publishers. Source


Rajasekaran P.,Ruhr University Bochum | Oplander C.,RWTH Aachen | Hoffmeister D.,University of Science and Arts of Iran | Bibinov N.,Ruhr University Bochum | And 3 more authors.
Plasma Processes and Polymers | Year: 2011

Atmospheric-pressure dielectric barrier discharge (DBD) in air is investigated for medical applications, especially for skin treatment. When the DBD was tested on mouse skin, a homogeneous discharge accompanied by filamentary microdischarges is observed. For characterization of the homogeneous discharge, averaged plasma parameters (namely electron density and electron velocity distribution function) and gas temperature are determined by optical emission spectroscopy, microphotography and numerical simulation. Chemical kinetics in the active plasma volume and in the afterglow is simulated. Fluxes of biologically useful molecules like nitric oxide (NO) and ozone reaching the treated surface and irradiation by UV photons are determined. Skin biopsy results show that DBD treatment causes no inflammation and no changes in the skin-collagen. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Patent
CINOGY GmbH | Date: 2013-07-18

An electrode arrangement for forming a dielectrically impeded plasma between an active surface of a flexible, planar electrode that can be connected to a high voltage source has a planar, flexible dielectric that forms the active surface which is connected to the planar electrode to form an electrode element where the electrode is completely covered towards to surface to be treated. The electrode arrangement is adaptable to irregular surfaces using a contact with surface elasticity for pressing onto the rear face of the electrode element facing away from the surface such that the electrode element by local deformation is automatically adapted to the irregularities.

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