Cincinnati Center for Growth Disorders

Cincinnati, Ohio, United States

Cincinnati Center for Growth Disorders

Cincinnati, Ohio, United States
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Rosenfeld R.G.,Oregon Health And Science University | Hwa V.,Cincinnati Center for Growth Disorders | Hwa V.,Cincinnati Childrens Hospital Medical Center
Annales d'Endocrinologie | Year: 2017

Normal growth requires that pituitary-secreted growth hormone (GH) bind to its specific receptor and activate a complex signaling cascade, leaving to production of insulin-like growth factor-I (IGF-I), which, in turn, activates its own receptor (IGF1R). The GH receptor (GHR) is preformed as a dimer and is transported in a nonligand bound state to the cell surface. Binding of GH to the GHR dimer, results in a conformational change of the dimer, activation of the intracellular Janus Kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription (STAT) 5B. Phosphorylated STAT5B dimers are then translocated to the nucleus, where they transcriptionally activate multiple genes, including those for IGF-I, IGF binding protein-3 and the acid-labile subunit (ALS). © 2017 Elsevier Masson SAS.

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