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News Article | May 5, 2017
Site: www.eurekalert.org

New York, NY, May 5, 2017 - An international group of experts has concluded that, for patients with schizophrenia and related psychotic disorders, antipsychotic medications do not have negative long-term effects on patients' outcomes or the brain. In addition, the benefits of these medications are much greater than their potential side effects. These findings, by Jeffrey Lieberman, MD, Lawrence C. Kolb Professor and Chairman of Psychiatry at Columbia University College of Physicians and Surgeon and Director of the New York State Psychiatric Institute, and colleagues from institutions in the United States, Germany, The Netherlands, Austria, Japan, and China, were published today in the American Journal of Psychiatry. Nearly seven million Americans take antipsychotic medications for the treatment of schizophrenia and related conditions. The medications are prescribed to alleviate the symptoms of psychosis and longer-term, to prevent relapse. In recent years, however, concerns have been raised that these medications could have toxic effects and negatively impact long-term outcomes. This view, if not justified by data, has the potential mislead some patients (and their families) to refuse or discontinue antipsychotic treatment. For this reason, the researchers undertook a comprehensive examination of clinical and basic research studies that examined the effects of antipsychotic drug treatment on the clinical outcomes of patients and changes in brain structure. "The evidence from randomized clinical trials and neuroimaging studies overwhelmingly suggests that the majority of patients with schizophrenia benefit from antipsychotic treatment, both in the initial presentation of the disease and for longer-term maintenance to prevent relapse," said Dr. Lieberman. Moreover, whatever side effects that these medications might cause are greatly outweighed by their therapeutic benefits. "Anyone who doubts this conclusion should talk with people whose symptoms have been relieved by treatment and literally given back their lives," Lieberman added. The studies also revealed that delaying or withholding treatment has been associated with poorer long-term outcomes. "While a minority of patients who recover from an initial psychotic episode may maintain their remission without antipsychotic treatment, there is currently no clinical biomarker to identify them, and it is a very small number of patients who may fall into this subgroup," said Dr. Lieberman. "Consequently, withholding treatment could be detrimental for most patients with schizophrenia." And while preclinical studies in rodents suggested that antipsychotic medications can sensitize dopamine receptors, there is no evidence that antipsychotic treatment increases the risk of relapse. While antipsychotic medications can increase the risk for metabolic syndrome, which is linked to heart disease, diabetes, and stroke, the study did not include a risk-benefit analysis. "While more research is needed to address these questions, the strong evidence supporting the benefits of antipsychotic medications should be made clear to patients and their families, while at the same time they should be used judiciously" said Dr. Lieberman. The paper is entitled, "The Long-Term Effects of Antipsychotic Medication on Clinical Course in Schizophrenia." The authors are Donald Goff, MD (New York University School of Medicine, New York, NY), Peter Falkai, MD, PhD (Ludwig-Maximilians-University Munich, Germany), Wolfgang Fleischhacker, MD, (Medical University of Innsbruck, Austria), Ragy Girgis, MD (Columbia University Medical Center), Rene M. Kahn, MD, PhD (University Medical Center, Utrecht, The Netherlands;), Hiroyuki Uchida, MD, PhD (Keiyo University, Tokyo, Japan), Jingping Zhao, MD, Ph.D. (Central South University, Chengsha, China), and Jeffrey Lieberman, MD (Columbia University Medical Center and New York State Psychiatric Institute). Dr. Goff has received research support from Avanir Pharmaceuticals, the National Institute of Mental Health, and the Stanley Medical Research Institute. Dr. Fleischhacker has received research support from Boehringer-Ingelheim, Janssen, Lundbeck, and Otsuka; he has received honoraria for serving as a consultant to and/or on advisory boards for Allergan, Dainippon-Sumitomo, GedeonRichter, Janssen, Lundbeck, Otsuka, Takeda, and Teva; and he has received speaker's fees and travel support from AOP Orphan, Dainippon Sumitomo, Gedeon Richter, Janssen, Lundbeck, Pfizer, Otsuka, and Teva. Dr. Girgis receives research support from Allergan, BioAdvantex, Genentech, and Otsuka. Dr. Kahn has received consulting fees from Alkermes, Forrest, Forum, Gedeon-Richter, Janssen-Cilag, Minerva Neurosciences, and Sunovion and speaker's fees from Janssen-Cilag and Lilly. Dr. Uchida has received grants from Astellas Pharmaceutical, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Meiji-Seika Pharmaceutical, Mochida Pharmaceutical, Novartis, Otsuka Pharmaceutical, and Shionogi; speaker's honoraria from Dainippon-Sumitomo Pharma, Eli Lilly, Janssen Pharmaceutical, Meiji-Seika Pharma, MSD, Otsuka Pharmaceutical, Pfizer, Shionogi, and Yoshitomi Yakuhin; and advisory panel payments from Dainippon-Sumitomo Pharma. All other authors report no financial relationships with commercial interests. New York State Psychiatric Institute and Columbia University Department of Psychiatry (NYSPI/Columbia Psychiatry). New York State Psychiatric Institute (founded in 1896) and the Columbia University Department of Psychiatry have been closely affiliated since 1925. Their co-location in a New York State facility on the New York-Presbyterian/Columbia University Medical Center campus provides the setting for a rich and productive collaborative relationship among scientists and physicians in a variety of disciplines. NYSPI/Columbia Psychiatry is ranked among the best departments and psychiatric research facilities in the nation and has contributed greatly to the understanding of and current treatment for psychiatric disorders. The Department and Institute are home to distinguished clinicians and researchers noted for their clinical and research advances in the diagnosis and treatment of depression, suicide, schizophrenia, bipolar and anxiety disorders and childhood psychiatric disorders. Their combined expertise provides state of the art clinical care for patients, and training for the next generation of psychiatrists and psychiatric researchers. Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. The campus that Columbia University Medical Center shares with its hospital partner, NewYork-Presbyterian, is now called the Columbia University Irving Medical Center. For more information, visit cumc.columbia.edu or columbiadoctors.org.


News Article | April 24, 2017
Site: www.prnewswire.co.uk

Republic Group Budapest, one of the most well-known Hungarian, international award winning (e.g. Cannes Golden Media Lion) agencies in Hungary, and also the organizer of Brand Festival (Central Europe's well-established brand strategy and advertising conference) started a cooperation with Branded Content Marketing Association Worldwide in order to educate the CEE. Background: Media has changed tremendously over the last decade and the consumers are explicitly expressing their opinion about Ad Agencies' achievements: 615 million computers are running ad blockers and one of ten users deliberately blocking out ads from their everyday life. These figures are alarmingly high but the situation is not hopeless indeed. According to the same researches, 77% of the interviewed users are open to new and exciting solutions, and do not reject advertising completely. They just simply want new forms, new content and new language. A brand new solution like branded content. "If we won't be not able to create incredibly useful, enjoyable and inspirational content for our customers, we will be out of business within the next few years" - said Gabor Fabricius, strategic director of Republic Group Budapest. Therefore Republic Group Budapest in alliance with BCMA would like not only to introduce the opportunities of using the tools of branded content but also to raise awareness regarding (mostly declining) advertising consumption of Generation Y and Z. About Republic Group Budapest: Republic Group Budapest is not just strategically supported by the New York based , but also one of the few, independent advertising agencies, whose outstanding professional work is shown in the number of national and international awards. In the last two decades the agency has worked for: Raiffeisen Bank, Unicredit Bank, UNIQA, K&H, ING, Budapest Bank, BMG, Formatex, Transparency International, Quicksilver, Nike, GSK, Bayer, Janssen-Cilag, Saint-Goban, Market, Garnier, L'Oreal, Rossmann, Vodafone, T-Mobile, Four Seasons Budapest, British Council, EON, GVH, EMIH, Audi, Mercedes Benz, Honda, Opel, Coca-Cola, British American Tobacco, Imperial Tobacco, Hell, Brau Union, Rauch, Gösser, Kaiser, Danone.


News Article | April 24, 2017
Site: www.prnewswire.com

Republic Group Budapest, one of the most well-known Hungarian, international award winning (e.g. Cannes Golden Media Lion) agencies in Hungary, and also the organizer of Brand Festival (Central Europe's well-established brand strategy and advertising conference) started a cooperation with Branded Content Marketing Association Worldwide in order to educate the CEE. Background: Media has changed tremendously over the last decade and the consumers are explicitly expressing their opinion about Ad Agencies' achievements: 615 million computers are running ad blockers and one of ten users deliberately blocking out ads from their everyday life. These figures are alarmingly high but the situation is not hopeless indeed. According to the same researches, 77% of the interviewed users are open to new and exciting solutions, and do not reject advertising completely. They just simply want new forms, new content and new language. A brand new solution like branded content. "If we won't be not able to create incredibly useful, enjoyable and inspirational content for our customers, we will be out of business within the next few years" - said Gabor Fabricius, strategic director of Republic Group Budapest. Therefore Republic Group Budapest in alliance with BCMA would like not only to introduce the opportunities of using the tools of branded content but also to raise awareness regarding (mostly declining) advertising consumption of Generation Y and Z. About Republic Group Budapest: Republic Group Budapest is not just strategically supported by the New York based , but also one of the few, independent advertising agencies, whose outstanding professional work is shown in the number of national and international awards. In the last two decades the agency has worked for: Raiffeisen Bank, Unicredit Bank, UNIQA, K&H, ING, Budapest Bank, BMG, Formatex, Transparency International, Quicksilver, Nike, GSK, Bayer, Janssen-Cilag, Saint-Goban, Market, Garnier, L'Oreal, Rossmann, Vodafone, T-Mobile, Four Seasons Budapest, British Council, EON, GVH, EMIH, Audi, Mercedes Benz, Honda, Opel, Coca-Cola, British American Tobacco, Imperial Tobacco, Hell, Brau Union, Rauch, Gösser, Kaiser, Danone.


ALLSCHWIL/BASEL, SWITZERLAND - 15 May 2017 - Actelion Ltd (SIX: ATLN) today announced changes to its executive team that would only take effect upon closing of the transaction with Johnson & Johnson expected towards the end of the second quarter 2017. Johnson & Johnson has appointed Jane Griffiths as the Global Head of Actelion, to take effect upon closing of the transaction. Dr. Griffiths, PhD has served as the Company Group Chairman, Janssen EMEA, since January 2011. Prior to leading Janssen EMEA, she was responsible for the EMEA Market Access unit. She has also served as International Vice President for Janssen-Cilag Northern Europe; Vice President, EMEA Biopharmaceuticals; and Managing Director, Ortho Biotech UK & Ireland. Otto Schwarz, PhD, will retire from his position as Chief Operating Officer, upon close of the transaction. He will work closely with Jane Griffiths as senior advisor for the 12 months following the completion of the transaction on the smooth integration of Actelion into Janssen/Johnson & Johnson and the seamless execution of Actelion's commercial strategies to maintain the strong momentum. Jean-Paul Clozel, MD, Chief Executive Officer, commented: "I would like to thank Otto for his very significant contributions to the success of Actelion in the almost 9 years since he joined the company. Under his leadership Tracleer was built into a global brand with almost 1.7 billion Swiss francs in peak sales. He also led and managed the highly successful launches of Opsumit, Uptravi and Veletri, thus replacing the leading drug in the category with a diversified, outcome-based portfolio, which has a strong long-term growth potential to achieve leading positions in shaping the treatment paradigms in PAH, an achievement which is a rare feat  in our industry." NOTES TO EDITORS                     Actelion Ltd. Actelion Ltd. is a leading biopharmaceutical company focused on the discovery, development and commercialization of innovative drugs for diseases with significant unmet medical needs. Actelion is a leader in the field of pulmonary arterial hypertension (PAH). Our portfolio of PAH treatments covers the spectrum of disease, from WHO Functional Class (FC) II through to FC IV, with oral, inhaled and intravenous medications. Although not available in all countries, Actelion has treatments approved by health authorities for a number of specialist diseases including Type 1 Gaucher disease, Niemann-Pick type C disease, Digital Ulcers in patients suffering from systemic sclerosis, and mycosis fungoides in patients with cutaneous T-cell lymphoma. Founded in late 1997, with now over 2,600 dedicated professionals covering all key markets around the world including the US, Japan, China, Russia and Mexico, Actelion has its corporate headquarters in Allschwil / Basel, Switzerland. Actelion shares are traded on the SIX Swiss Exchange (ticker symbol: ATLN). All trademarks are legally protected. For further information please contact: Andrew C. Weiss Senior Vice President, Head of Investor Relations & Corporate Communications Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil +41 61 565 62 62 www.actelion.com The above information contains certain "forward-looking statements", relating to the company's business, which can be identified by the use of forward-looking terminology such as "estimates",  "believes", "expects", "may", "are expected to", "will", "will continue", "should", "would be", "seeks",  "pending" or "anticipates" or similar expressions, or by discussions of strategy, plans or intentions.  Such statements include descriptions of the company's investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company's existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.


ALLSCHWIL/BASEL, SWITZERLAND, 17-May-2017 — /EuropaWire/ — Actelion Ltd (SIX: ATLN) today announced changes to its executive team that would only take effect upon closing of the transaction with Johnson & Johnson expected towards the end of the second quarter 2017. Johnson & Johnson has appointed Jane Griffiths as the Global Head of Actelion, to take effect upon closing of the transaction. Jane Griffiths, PhD has served as the Company Group Chairman, Janssen EMEA, since January 2011. Prior to leading Janssen EMEA, she was responsible for the EMEA Market Access unit. She has also served as International Vice President for Janssen-Cilag Northern Europe; Vice President, EMEA Biopharmaceuticals; and Managing Director, Ortho Biotech UK & Ireland. Otto Schwarz, PhD, will retire from his position as Chief Operating Officer, upon close of the transaction. He will work closely with Jane as senior advisor for the 12 months following the completion of the transaction on the smooth integration of Actelion into Janssen/Johnson & Johnson and the seamless execution of Actelion’s commercial strategies to maintain the strong momentum. Jean-Paul Clozel, MD, Chief Executive Officer, commented: “I would like to thank Otto for his very significant contributions to the success of Actelion in the almost 9 years since he joined the company. Under his leadership Tracleer was built into a global brand with almost 1.7 billion Swiss francs in peak sales. He also led and managed the highly successful launches of Opsumit, Uptravi and Veletri, thus replacing the leading drug in the category with a diversified, outcome-based portfolio, which has a strong long-term growth potential to achieve leading positions in shaping the treatment paradigms in PAH, an achievement which is a rare feat  in our industry.” Actelion Ltd. Actelion Ltd. is a leading biopharmaceutical company focused on the discovery, development and commercialization of innovative drugs for diseases with significant unmet medical needs. Actelion is a leader in the field of pulmonary arterial hypertension (PAH). Our portfolio of PAH treatments covers the spectrum of disease, from WHO Functional Class (FC) II through to FC IV, with oral, inhaled and intravenous medications. Although not available in all countries, Actelion has treatments approved by health authorities for a number of specialist diseases including Type 1 Gaucher disease, Niemann-Pick type C disease, Digital Ulcers in patients suffering from systemic sclerosis, and mycosis fungoides in patients with cutaneous T-cell lymphoma. Founded in late 1997, with now over 2,600 dedicated professionals covering all key markets around the world including the US, Japan, China, Russia and Mexico, Actelion has its corporate headquarters in Allschwil / Basel, Switzerland. Actelion shares are traded on the SIX Swiss Exchange (ticker symbol: ATLN). All trademarks are legally protected. For further information please contact: Andrew C. Weiss Senior Vice President, Head of Investor Relations & Corporate Communications Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil +41 61 565 62 62 www.actelion.com The above information contains certain “forward-looking statements”, relating to the company’s business, which can be identified by the use of forward-looking terminology such as “estimates”,  “believes”, “expects”, “may”, “are expected to”, “will”, “will continue”, “should”, “would be”, “seeks”,  “pending” or “anticipates” or similar expressions, or by discussions of strategy, plans or intentions.  Such statements include descriptions of the company’s investment and research and development programs and anticipated expenditures in connection therewith, descriptions of new products expected to be introduced by the company and anticipated customer demand for such products and products in the company’s existing portfolio. Such statements reflect the current views of the company with respect to future events and are subject to certain risks, uncertainties and assumptions. Many factors could cause the actual results, performance or achievements of the company to be materially different from any future results, performances or achievements that may be expressed or implied by such forward-looking statements. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described herein as anticipated, believed, estimated or expected.

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