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Villa Clara, Cuba

Schwartzman U.P.y.,Hospital Sarah Brasilia | Batista K.T.,Hospital Sarah Brasilia | Duarte L.T.D.,Servicos Medicos de Anestesia do Hospital Sirio Libanes | Saraiva R.A.,Hospital Sarah Brasilia | And 3 more authors.
Revista Brasileira de Anestesiologia | Year: 2014

Introduction: Approximately 234 million surgeries are done annually worldwide. There is a growing concern for the safety of the anesthetic act, and the pre-anesthetic consultation emerges as an important and widely recommended activity, used as a preventive measure for the emergence of a complication. Objectives: To describe the complications related to anesthesia, to identify the factors that contribute to its appearance and to reflect on ways to improve clinical practice. Methods: 700 patients, 175 cases and 525 controls, were evaluated over a period of 21 months. The data obtained through the pre-anesthetic consultation were evaluated descriptively and then tested with conditional univariate and multivariate logistic regression analysis. Results: 175 cases of anesthesia-related complications (2.74%) out of 6365 anesthetic acts were evaluated. Hypotension was the most common complication (40 patients, 22.8%), followed by vomiting (24 patients, 13.7%) and arrhythmia (24 patients, 13.7%). Among the complications, 55% were due to patient conditions, 26% accidental, 10% predictable and 9% iatrogenic. The complications were classified as mild in 106 (61%), moderate in 63 (36%) and severe in six (3%) patients. Conclusion: Patients with more impaired physical status (American Society of Anaesthesiology 3 and 4), with airway disease, tumor or parenchymal disease, diabetes or disorder of lipid metabolism, thyroid disease, former smokers and very prolonged anesthetic acts present a higher risk of anesthesia-related complications. Therefore, they should be actively investigated in the pre-anesthetic evaluation consultation. © 2014 Sociedade Brasileira de Anestesiologia. Source

Giovelli L.L.,Federal University of Santa Maria | Danieli K.,Federal University of Santa Maria | Bortolotto A.N.,Federal University of Santa Maria | Mastella A.K.,Ciencias Farmaceuticas | And 5 more authors.
Jornal Brasileiro de Patologia e Medicina Laboratorial | Year: 2011

Introduction: The sickle cell trait is the presence of hemoglobin S (HbS) in heterozygosity. According to RDC regulation 153/04, abnormal hemoglobin screening has become mandatory in blood donation samples since June 2004. Objective: The aim of this study was to compare different screening methods used in blood banks for HbS detection. Material and method: From April 2007 to April 2008, three HbS detection methods were applied in 4,108 suitable blood samples from the blood bank of the University Hospital of Santa Maria (HUSM). The comparative study among the methods comprised solubility tests and gel-centrifuge (ID-HbS). Furthermore, the positivity reference was the presence of HbS on hemoglobin electrophoresis. Results: Twentythree (0.56%) out of 4,108 samples showed positivity for HbS and two (0.05%) showed positivity for HbC. Twenty-two (95.6%) out of 23 HbS positive samples determined through qualitative electrophoresis were detected by solubility test and 20 (86.9%) were detected by gel-centrifugation test. Conclusion: Hemoglobin electrophoresis proved the best method in the identification of hemoglobin variants and, therefore, worthwhile when it comes to diagnostic screening in blood banks due to its high sensitivity, which keeps false-negative results to a minimum and ensures blood quality. Source

Hernandez Y.S.,University Central Of Las Villas Uclv | Safa B.M.,Ciencias Farmaceuticas | Bedia M.M.G.,Ciencias Farmaceuticas | Miguel H.M.G.S.,University of Habana | And 5 more authors.
Revista Cubana de Plantas Medicinales | Year: 2010

INTRODUCTION: It is required a specific analysis technique allowing the follow-up to stability study intrinsic of Parthenium hysterophorus L. (escoba amarga) powdered dry foliage to achieve in a pharmaceutical way a antiparasitic usefulness with the quality, safety and effectiveness demanded requirements. OBJECTIVE: to demonstrate the specificity of analytical technique of highperformance liquid chromatography for quantization of partenine in the powder of P. hysterophorus for its application in stability studies. METHODS: high performance liquid chromatography was applied to P. hysterophorus degraded samples under degradation conditions in an oxidative, basic and acid medium.The analysis technique specificity was assessed to detect the interest component without interferences of its degradation products and its possible usefulness in studies on solid stability in the plant powder. RESULTS: high-performance liquid chromatography to quantify the presence of partenine in the P. hysterophorus powder was specific in established work conditions and may be used in solid stability studies of plant powder. CONCLUSIONS: the high-performance proposed is specific and it is recommended in solid stability studies of solids in plant powder. Source

Gomez A.M.,Ciencias Farmaceuticas | Lorenzo M.O.,Ciencias Farmaceuticas | Gonzalez Y.G.,Especialista 1er Grado Medicina Interna
Revista del Hospital Psiquiatrico de la Habana | Year: 2014

Introduction. Drugs of abuse is a scourge expanded globally. Cuba is no stranger to this situation. To characterize the behavior of drug poisonings consulted abuse center in the last nine years, through the analysis of epidemiological variables: age, sex, and agents used. Method: A descriptive cross-sectional study of poisoning by drugs abuse consulted the period 2004-2012 was performed. Data were collected from 4902 the ETS Model Toxicology consulted the Emergency Information Service. Results: 1270 inquiries were received replies intoxicated by drugs, (5% of all intoxicated). Patients were predominantly 15-19 years (41%) and male (73.3%). In 48.3% of cases were used combination products. The drink/drug combination was the most used. Anticonvulsant drugs and alcohol were ingested more frequently. Conclusions: Drug Abuse poisoning consulted our center, have been increasing. The age and sex behavior is similar each year, with adolescent males the most impact. The combination of substances is the most common form of abuse, being coingestión alcohol with the drugs used. The use of drugs for purposes of abuse has increased, whether used as a single agent or in combination with other substances. Carbamazepine is the drug most widely used. Bell and Marijuana is the illicit drug most reported cases. Source

De Oliveira Silveira A.C.,Ciencias Farmaceuticas | De Oliveira Silveira A.C.,Regional University of Blumenau | D'Azevedo P.A.,Laboratorio Especial Of Microbiologia Clinica Lemc | D'Azevedo P.A.,Federal University of Health Sciences, Porto Alegre
Jornal Brasileiro de Patologia e Medicina Laboratorial | Year: 2011

Coagulase-negatives staphylococci (CNS) are Gram-positives cocci commonly regarded as contaminants in clinical microbiology laboratories. Despite belonging to this group, Staphylococcus lugdunensis may cause complicated infections such as endocarditis, skin infections and soft tissue, osteomyelitis, among others. Apart from the formation of biofilms, it has pathogenic features similar to Staphylococcus aureus. It may be mistakenly identified as S. aureus when using rapid identification tests, such as clumping factor in slide coagulase or in agglutination latex tests. It is easily identified through available biochemical tests, such as the presence of ornithine decarboxylase and pyrrolidonyl arylamidase (PYR). It presents sensitivity to most antimicrobial agents. Furthermore, the presence of beta-lactamase and mecA gene should be routinely investigated by testing with chromogenic cephalosporin and cefoxitin susceptibility, respectively. It is convenient to highlight that the interpretative criteria used to evaluate cefoxitin sensitivity are the same recommended for S. aureus and different from those used for other CNS. Despite the fact it is atypical, S. lugdunensis is a virulent pathogen, which must be accurately identified insofar as it will rarely be deemed as a contaminant when isolated from sterile sites. Source

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