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Barcelona, Spain

Garnacho E.,CEFAS - Center for Environment, Fisheries and Aquaculture Science | Law R.J.,CEFAS - Center for Environment, Fisheries and Aquaculture Science | Schallier R.,Royal Belgian Institute Of Natural Sciences | Albaiges J.,CID CSIC
Marine Policy | Year: 2010

Accidental marine pollution can have major ecological and economic consequences at national and trans-national levels, and there is a need to achieve a better integration of science into actual decision-making systems to support prevention measures, response systems and management activities.. Effective linking mechanisms between R&D and end-users/policy stakeholders are required to ensure the relevance of R&D, effective uptake of R&D outputs, and suitable policy development. Different issues and barriers to effectively link accidental marine pollution R&D effort to end-users concerns and needs and to develop a trans-national strategic approach are identified, analysed, and further developed into recommendations. © 2010 Elsevier Ltd. Source


Morales-Nin B.,CSIC - Mediterranean Institute for Advanced Studies | Albaiges J.,CID CSIC
Marine Policy | Year: 2015

The aim of the SEAS-ERA initiative (2010-2014), developed within the European Union Framework Programme (EU FPVII) (contract 249552), was to coordinate the structure of national and regional marine and maritime research programs to empower and strengthen marine research all across Europe. A major goal was the development and implementation of common research strategies and programs related to European seas basins. To achieve this goal, SEAS-ERA was applied at two different levels, regional and pan European, to identify common priorities and needs in five areas, namely strategic planning (marine research agendas), joint research activities (common programs and joint calls), marine research infrastructures and human capacity building to reduce imbalances among regions. SEAS-ERA was also strongly committed to enhancing public awareness of marine and maritime scientific and policy issues in Europe. © 2015 Elsevier Ltd. Source


Zotti M.J.,Ghent University | Zotti M.J.,Federal University of Pelotas | Zotti M.J.,Federal University of Santa Maria | De Geyter E.,Ghent University | And 8 more authors.
Pesticide Biochemistry and Physiology | Year: 2013

Ecdysteroid signal transduction is a key process in insect development and therefore an important target for insecticide development. We employed an in vitro cell-based reporter bioassay for the screening of potential ecdysone receptor (EcR) agonistic and antagonistic compounds. Natural ecdysteroids were assayed with ecdysteroid-responsive cell line cultures that were transiently transfected with the reporter plasmid ERE-b.act.luc. We used the dipteran Schneider S2 cells of Drosophila melanogaster and the lepidopteran Bm5 cells of Bombyx mori, representing important pest insects in medicine and agriculture. Measurements showed an EcR agonistic activity only for cyasterone both in S2 (EC50=3.3μM) and Bm5 cells (EC50=5.3μM), which was low compared to that of the commercial dibenzoylhydrazine-based insecticide tebufenozide (EC50=0.71μM and 0.00089μM, respectively). Interestingly, a strong antagonistic activity was found for castasterone in S2 cells with an IC50 of 0.039μM; in Bm5 cells this effect only became visible at much higher concentrations (IC50=18μM). To gain more insight in the EcR interaction, three-dimensional modeling of dipteran and lepidopteran EcR-LBD was performed. In conclusion, we showed that the EcR cell-based reporter bioassay tested here is a useful and practical tool for the screening of candidate EcR agonists and antagonists. The docking experiments as well as the normal mode analysis provided evidence that the antagonist activity of castasterone may be through direct binding with the receptor with specific changes in protein flexibility. The search for new ecdysteroid-like compounds may be particularly relevant for dipterans because the activity of dibenzoylhydrazines appears to be correlated with an extension of the EcR-LBD binding pocket that is prominent in lepidopteran receptors but less so in the modeled dipteran structure. © 2013 Elsevier Inc. Source


Vinas L.,Spanish Institute of Oceanography | Angeles Franco M.,Spanish Institute of Oceanography | Antonio Soriano J.,Spanish Institute of Oceanography | Jose Gonzalez J.,Spanish Institute of Oceanography | And 2 more authors.
Environmental Pollution | Year: 2010

The distribution of polycyclic aromatic hydrocarbons was determined in surface sediments collected at 36 stations along the Spanish Northern continental shelf in March and September 2003, and February 2005. Concentrations of PAHs (Σ13 parent components) were in the range of 22-47528 μg/kg dw, the highest values corresponding to coastal urban-industrial hotspots and decreasing offshore. Sediment quality guidelines (SQGs) showed that concentrations of total PAHs were below the threshold effect level (TEC) in 27 stations (81%) and above in 7, two of which (Gijon and Bilbao) were above the probable effect concentration (PEC). The detailed study of diagnostic ratios suggested a rather uniform mixture of petrogenic and pyrolytic PAH sources along the continental shelf, with a slight decrease of the latter moving westwards and offshore. In order to assess the incidence of sediment sampling on the variability of the results, selected stations were also monitored in February and September 2004 and September 2005. The average field variance of the values obtained for each station was 31% that decreased to 23% when the values were normalized to TOC. © 2009 Elsevier Ltd. All rights reserved. Source

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