CIBA Vision Corporation

Johns Creek, GA, United States

CIBA Vision Corporation

Johns Creek, GA, United States

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Sankaridurg P.,Brien Holden Vision Institute | Sankaridurg P.,Vision Cooperative Research Center | Sankaridurg P.,University of New South Wales | Holden B.,Brien Holden Vision Institute | And 18 more authors.
Investigative Ophthalmology and Visual Science | Year: 2011

Purpose. To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia. Methods. Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 45) and followed up for 12 months, and their progress was compared with that of a group (n = 40) matched for age, sex, refractive error, axial length, and parental myopia wearing normal, single-vision, spherocylindrical spectacles. Results. On adjusting for parental myopia, sex, age, baseline spherical equivalent (SphE) values, and compliance, the estimated progression in SphE at 12 months was 34% less, at -0.57 D, with the novel contact lenses (95% confidence interval [CI], -0.45 -0.69 D) than at -0.86 D, with spectacle lenses (95% CI, -0.74 to -0.99 D). For an average baseline age of 11.2 years, baseline SphE of -2.10 D, a baseline axial length of 24.6 mm, and 320 days of compliant lens wear, the estimated increase in axial length (AL) was 33% less at 0.27 mm (95% CI, 0.22-0.32 mm) than at 0.40 mm (95% CI, 0.35-0.45 mm) for the contact lens and spectacle lens groups, respectively. Conclusions. The 12-month data support the hypothesis that reducing peripheral hyperopia can alter central refractive development and reduce the rate of progress of myopia. © 2011 The Association for Research in Vision and Ophthalmology, Inc.


Baio J.E.,University of Washington | Weidner T.,University of Washington | Samuel N.T.,University of Washington | Samuel N.T.,CIBA VISION Corporation | And 4 more authors.
Journal of Vacuum Science and Technology B:Nanotechnology and Microelectronics | Year: 2010

The ability to orient biologically active proteins on surfaces is a major challenge in the design, construction, and successful deployment of many medical technologies. As methods to orient biomolecules are developed, it is also essential to develop techniques that can accurately determine the orientation and structure of these materials. In this study, two model protein and peptide systems are presented to highlight the strengths of three surface analysis techniques for characterizing protein films: time-of-flight secondary-ion mass spectrometry (ToF-SIMS), sum-frequency generation (SFG) vibrational spectroscopy, and near-edge x-ray absorption fine structure (NEXAFS) spectroscopy. First, the orientation of Protein G B1, a rigid 6 kDa domain covalently attached to a maleimide-functionalized self-assembled monolayer, was examined using ToF-SIMS. Although the thickness of the Protein G layer was similar to the ToF-SIMS sampling depth, orientation of Protein G was successfully determined by analyzing the C2H5S+ intensity, a secondary-ion derived from a methionine residue located at one end of the protein. Next, the secondary structure of a 13-mer leucine-lysine peptide (LK 310) adsorbed onto hydrophilic quartz and hydrophobic fluorocarbon surfaces was examined. SFG spectra indicated that the peptide's lysine side chains were ordered on the quartz surface, while the peptide's leucine side chains were ordered on the fluorocarbon surface. NEXAFS results provided complementary information about the structure of the LK 310 film and the orientations of amide bonds within the LK 310 peptide. © 2010 American Vacuum Society.


Dong H.,Carnegie Mellon University | Huang J.,CIBA Vision Corporation | Koepsel R.R.,McGowan Institute for Regenerative Medicine | Ye P.,Carnegie Mellon University | And 2 more authors.
Biomacromolecules | Year: 2011

Highly efficient recyclable antibacterial magnetite nanoparticles consisting of a magnetic Fe3O4 core with an antibacterial poly(quaternary ammonium) (PQA) coating were prepared in an efficient four-step process. The synthetic pathway included: (1) preparation of Fe3O 4 nanoparticles via coprecipitation of Fe2+/Fe 3+ in the presence of an alkaline solution; (2) attachment of an ATRP initiating functionality to the surface of the nanoparticles; (3) surface-initiated atom transfer radical polymerization (ATRP) of 2-(dimethylamino)ethyl methacrylate (DMAEMA); and (4) transformation of PDMAEMA brushes to PQA via quaternization with ethyl bromide. The success of the surface functionalization was confirmed by FT-IR, thermal gravimetric analysis (TGA), elemental analysis, and transmission electron microscopy (TEM). The PQA-modified magnetite nanoparticles were dispersed in water and exhibited a response to an external magnetic field, making the nanoparticles easy to remove from water after antibacterial tests. The PQA-modified magnetite nanoparticles retained 100% biocidal efficiency against E. coli (105 to 106E. coli/mg nanoparticles) during eight exposure/collect/recycle procedures without washing with any solvents or water. © 2011 American Chemical Society.


Fahmy M.,CIBA Vision Corporation | Long B.,Independent Project Management | Giles T.,CIBA Vision Corporation | Wang C.-H.,CIBA Vision Corporation
Eye and Contact Lens | Year: 2010

ObjectiveS:: The primary objective of this trial was to explore the extent to which common contact lens-related symptoms may be improved among symptomatic daily wear contact lens wearers who habitually replaced their lenses at intervals of 1 to 4 weeks when fitted with DAILIES AquaComfort Plus for daily disposable, daily wear. Primary variables were frequency and severity of tired eyes, irritated eyes, lens awareness, blurred vision, redness, discomfort, deposits, and dryness. Methods:: Eight sites, investigators enrolled 83 subjects who reported two or more of the symptoms with frequency of often or always. A sample size estimate required 60 subjects for 80% power, two-sided α = 0.05. Subjects were dispensed for 4 weeks of bilateral lens wear. Follow-up visits were at 2 and 4 weeks; data were collected by telephone surveys at 1 and 3 weeks. Results:: Eighty-one subjects completed the trial. Statistically significant improvements in symptom frequency were found for the symptoms of tired eyes (P<0.001), irritated eyes (P<0.001), blurred vision (P<0.001), redness (P<0.001), discomfort (P=0.024), deposits/lens needs cleaning (P<0.001), and dryness (P<0.001). Statistically significant improvements in symptom severity were found for tired eyes (P<0.001), irritated eyes (P<0.001), blurred vision (P<0.001), redness (P<0.001), discomfort (P=0.037), deposits/lens needs cleaning (P<0.001), and dryness (P<0.001). Biomicroscopy signs of limbal redness, bulbar redness, and conjunctival staining showed statistically significant improvements at 2 weeks (P=0.02, 0.01, and 0.035) and 4 weeks (P≤0.001, 0.012, and 0.008). Conclusions:: A range of common symptoms can be reduced and biomicroscopy signs can be improved with a comfort-enhanced daily disposable, daily wear lens, thus providing benefits that patients can experience and eye care practitioners can appreciate. © 2010 Lippincott Williams & Wilkins, Inc.


Ferryanto L.,CIBA Vision Corporation | Tollefson N.,CIBA Vision Corporation
Quality Engineering | Year: 2010

A split-split-plot design of experiments was applied to evaluate foil lidding for contact lens packages through the determination of the effect of the seal parameters to the peel behavior of the package. The experimental design structure was not completely randomized because of the lengthy time involved in temperature equilibration and the practicality of changing pressure. The quality of the package seal was evaluated by measuring continuous peel force and by classifying peel type as a categorical response. The significance and sensitivity level of the seal parameters were evaluated using analysis of variance (ANOVA)-based sensitivity analysis. Graphical and statistical model-based optimization determined that several sets of seal parameters were possible to optimize peel force, produce a robust seal-peel process, and minimize possibility of either leak or delamination. Copyright © Taylor & Francis Group, LLC.


Chalmers R.L.,Indiana University | Keay L.,University of Sydney | Long B.,Independent Project Management | Bergenske P.,CIBA VISION Corporation | And 2 more authors.
Optometry and Vision Science | Year: 2010

Purpose. To determine significant risk factors for any inflammatory and infectious events with soft contact lenses (SCL) in a large retrospective clinical chart review. Methods. Charts of patients who presented for SCL care from October 2005 through March 2006 were reviewed and observed for a potential of at least 2 years. Charts from those with office visits involving an event-requiring pharmacologic treatment and/or interruption of SCL wear were scanned and later adjudicated by a masked panel. Significant factors from a univariate analysis were included in a multivariate analysis for all events and subcategories of events separately. Overnight wear was not consistently recorded and was not analyzed. Results. Charts from 1276 SCL wearers comprised 4120 visits and 1454 years of SCL wear (2908 eye/yr) and included 306 events of interest in 228 patients. In a multivariate analysis, age <25 years was significantly associated with presenting any event, inflammatory events, and infectious events that may or may not be CL-related [incidence rate ratio (IRR) = 1.3; 95% CI, 1.0 to 1.7; 2.6X, 1.5 to 4.6; and 2.0X, 1.2 to 3.3, respectively]. Ametropia >5.00 D increased risk of any event (IRR = 1.5; 1.2 to 1.9) and for other infectious events (IRR = 1.9; 1.2 to 3.2). Use of daily disposable lenses associated with lid irritation (IRR = 4.5; 2.1 to 9.8) but was not significantly associated with any other type of events. New and hydrogel lens wearers had a lower incidence of all event types (IRR = 0.07; 0.01 to 0.46 and 0.77; 0.59 to 0.99, respectively). Conclusions. Eighty-two percent of these SCL wearers did not present with any complications during the observation period >2 years. The risk factors for inflammatory and infectious events among SCL wearers in clinical practice are similar to those reported in prospective clinical trials. High ametropia and age <25 years are the risk factors that impact the most types of events. Copyright © 2010 American Academy of Optometry.


Weidner T.,University of Washington | Samuel N.T.,University of Washington | Samuel N.T.,CIBA VISION Corporation | McCrea K.,Polymer Technology Group Inc. | And 3 more authors.
Biointerphases | Year: 2010

The structure, orientation, and formation of amphiphilic α-helix model peptide films on fluorocarbon surfaces has been monitored with sum frequency generation SFG vibrational spectroscopy, near-edge x-ray absorption fine structure NEXAFS spectroscopy, and x-ray photoelectron spectroscopy XPS. The -helix peptide is a 14-mer of hydrophilic lysine and hydrophobic leucine residues with a hydrophobic periodicity of 3.5. This periodicity yields a rigid amphiphilic peptide with leucine and lysine side chains located on opposite sides. XPS composition analysis confirms the formation of a peptide film that covers about 75% of the surface. NEXAFS data are consistent with chemically intact adsorption of the peptides. A weak linear dichroism of the amide φ is likely due to the broad distribution of amide bond orientations inherent to the -helical secondary structure. SFG spectra exhibit strong peaks near 2865 and 2935 cm- related to aligned leucine side chains interacting with the hydrophobic surface. Water modes near 3200 and 3400 cm- indicate ordering of water molecules in the adsorbed-peptide fluorocarbon surface interfacial region. Amide I peaks observed near 1655 cm- confirm that the secondary structure is preserved in the adsorbed peptide. A kinetic study of the film formation process using XPS and SFG showed rapid adsorption of the peptides followed by a longer assembly process. Peptide SFG spectra taken at the air-buffer interface showed features related to well-ordered peptide films. Moving samples through the buffer surface led to the transfer of ordered peptide films onto the substrates. © 2010 American Vacuum Society.


Tucker B.,Ciba Vision Corporation | Kapoor Y.,Ciba Vision Corporation | Elliott S.,Ciba Vision Corporation
Experimental Techniques | Year: 2014

Polymerization often causes a decrease in material density as monomers are cross-linked to form a dense matrix. This decrease in volume can induce anisotropic stress and strain in the polymerized material leading to defects in the final product, especially if the strain is not dissipated. The measurement of polymerization stress can help in improving quality of the final product through changes in lens design, curing conditions, or formulation. This article focuses on development of an in situ force monitoring method, which monitors the polymerization force as the contact lens is formed between two mold halves. This force is an accumulation of multiple stresses such as prepolymer shrinkage and polymer-mold interactions. If polymerization stresses could be controlled during manufacturing, product yield could be improved. Well-established techniques, such as rheometry, were also used for further understanding of polymer curing. © 2012, Society for Experimental Mechanics.


Patent
Ciba Vision Corporation | Date: 2010-06-04

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.


Patent
CIBA Vision Corporation | Date: 2013-09-23

A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

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