Institute Of Endocrinology Ci Parhon

Bucharest, Romania

Institute Of Endocrinology Ci Parhon

Bucharest, Romania
SEARCH FILTERS
Time filter
Source Type

Mihaila S.,Carol Davila University of Medicine and Pharmacy | Mincu R.I.,Carol Davila University of Medicine and Pharmacy | Rimbas R.C.,University of Bucharest | Dulgheru R.E.,Carol Davila University of Medicine and Pharmacy | And 4 more authors.
Canadian Journal of Cardiology | Year: 2015

Background: Growth hormone deficiency (GHD) in adults is associated with increased cardiovascular events, but detailed assessment of cardiac and vascular function is lacking. Thus we assessed cardiac, arterial, and endothelial functions, using conventional and speckle-tracking echocardiography, in adults with GHD compared with controls with similar cardiovascular risk. Methods: Fifty-two patients with GHD (47 ± 16 years; 34 men) and no cardiovascular disease or diabetes were enrolled prospectively and compared with 50 age- and sex-matched controls. Comprehensive echocardiography was performed in all participants. Regional left ventricular (LV) function was assessed from global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS), whereas LV torsion (LVtor) was calculated from basal (RotB) and apical (RotA) rotations. Arterial function was assessed from intima-media thickening, local wave speed, and beta index of stiffness, whereas endothelial function was assessed from flow-mediated dilation. Levels of pro-brain natriuretic peptide (proBNP) were measured. Results: GLS and GCS were decreased more in patients with GHD than in controls (-17.2% ± 2.7% vs-19.3% ± 3.3% and-15.9% ± 5.4% vs-18.8% ± 3.5%; both P < 0.01), whereas GRS was similar. RotB and LVtor were also decreased in patients with GHD (-4.8° ± 2.6° vs-6.2° ± 2.1°/cm and 1.8° ± 0.6° vs 2.3° ± 1.1°/cm; both P < 0.05). ProBNP was increased in patients with GHD (61.0 ± 74 pg/dL vs 24.7 ± 21 pg/dL; P= 0.002). Arterial and endothelial functions were similar between groups. Conclusions: In conclusion, adults with GHD had LV longitudinal dysfunction and increased proBNP levels compared with controls, suggesting intrinsic myocardial disease. Further studies are needed to assess if this cardiac impairment in adults with GHD is reversible after GH replacement. Introduction: Le déficit en hormone de croissance (DHC) chez les adultes est associé à l'augmentation des événements cardiovasculaires. Cependant, l'analyse détaillée de la fonction cardiaque et vasculaire fait défaut. Par conséquent, nous avons évalué les fonctions cardiaque, artérielle et endothéliale au moyen de l'échocardiographie Speckle Tracking (suivi de pixel) et traditionnelle des adultes ayant un DHC par rapport aux témoins ayant un risque cardiovasculaire similaire. Méthodes: Cinquante-deux patients ayant un DHC (47 ± 16 ans; 34 hommes), mais pas de maladie cardiovasculaire ou de diabète ont été inscrits de manière prospective et comparés à 50 témoins appariés selon l'âge et le sexe. Nous avons réalisé une échocardiographie exhaustive chez tous les participants. Nous avons évalué la fonction régionale du ventricule gauche (VG) à partir de la déformation longitudinale globale (DLG), de la déformation radiale globale (DRG) et de la déformation circonférentielle globale (DCG), tandis que nous avons calculé la torsion du VG (torVG) à partir des rotations basales (rotB) et apicales (rotA). Nous avons évalué la fonction artérielle à partir de l'épaississement de l'intima-média, de la vitesse locale de l'onde et de l'indice de rigidité bêta, tandis que nous avons évalué la fonction endothéliale à partir de la dilatation médiée par le flux. Nous avons mesuré les concentrations du propeptide natriurétique de type B (proBNP). Résultats: La DLG et la DCG diminuaient plus chez les patients ayant un DHC que chez les témoins (-17,2 % ± 2,7 % vs -19,3 % ± 3,3 % et -15,9 % ± 5,4 % vs -18,8 % ± 3,5 %; P < 0,01 pour les deux), tandis que la DRG était similaire. La rotB et la torVG diminuaient également chez les patients ayant un DHC (-4,8° ± 2,6° vs -6,2°°± 2,1°/cm et 1,8°°± 0,6° vs 2,3°°± 1,1°/cm; P < 0,05 pour les deux). Le proBNP augmentait chez les patients ayant un DHC (61,0 ± 74 pg/dl vs 24,7 ± 21 pg/dl; P= 0,002). Les fonctions artérielle et endothéliale étaient similaires entre les groupes. Conclusions: En conclusion, les adultes ayant un DHC montraient une dysfonction longitudinale du VG et une augmentation des concentrations du proBNP par rapport aux témoins, ce qui suggère une myocardiopathie intrinsèque. D'autres études sont nécessaires pour évaluer si ce trouble cardiaque chez les adultes ayant un DHC est réversible après le remplacement de l'HC. © 2015 Canadian Cardiovascular Society.


PubMed | Institute Of Endocrinology Ci Parhon, Carol Davila University of Medicine and Pharmacy and University of Bucharest
Type: Comparative Study | Journal: The Canadian journal of cardiology | Year: 2015

Growth hormone deficiency (GHD) in adults is associated with increased cardiovascular events, but detailed assessment of cardiac and vascular function is lacking. Thus we assessed cardiac, arterial, and endothelial functions, using conventional and speckle-tracking echocardiography, in adults with GHD compared with controls with similar cardiovascular risk.Fifty-two patients with GHD (47 16 years; 34 men) and no cardiovascular disease or diabetes were enrolled prospectively and compared with 50 age- and sex-matched controls. Comprehensive echocardiography was performed in all participants. Regional left ventricular (LV) function was assessed from global longitudinal strain (GLS), global radial strain (GRS), and global circumferential strain (GCS), whereas LV torsion (LVtor) was calculated from basal (RotB) and apical (RotA) rotations. Arterial function was assessed from intima-media thickening, local wave speed, and beta index of stiffness, whereas endothelial function was assessed from flow-mediated dilation. Levels of pro-brain natriuretic peptide (proBNP) were measured.GLS and GCS were decreased more in patients with GHD than in controls (-17.2% 2.7% vs. -19.3% 3.3% and -15.9% 5.4% vs. -18.8% 3.5%; both P < 0.01), whereas GRS was similar. RotB and LVtor were also decreased in patients with GHD (-4.8 2.6 vs. -6.2 2.1/cm and 1.8 0.6 vs. 2.3 1.1/cm; both P < 0.05). ProBNP was increased in patients with GHD (61.0 74 pg/dL vs. 24.7 21 pg/dL; P = 0.002). Arterial and endothelial functions were similar between groups.In conclusion, adults with GHD had LV longitudinal dysfunction and increased proBNP levels compared with controls, suggesting intrinsic myocardial disease. Further studies are needed to assess if this cardiac impairment in adults with GHD is reversible after GH replacement.

Loading Institute Of Endocrinology Ci Parhon collaborators
Loading Institute Of Endocrinology Ci Parhon collaborators