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Tokyo, Japan

Chuo University , literally Central University, is a private university in Tokyo, renowned for its law school. Chuo is one of the most prestigious schools in Japan. The University has four campuses at Tama , at Korakuen , at Ichigaya , and at Ichigaya-Tamachi . Chuo University has six faculties, ten graduate schools, and nine research institutes. It also operates four high schools and two junior high schools. Wikipedia.


Yamashita M.,Chuo University
Bulletin of the Chemical Society of Japan | Year: 2011

A series of anionic boron compounds, possessing a polarized boronmetal bond, were synthesized and structurally characterized. Detailed analyses of these boryl anions using NMR spectroscopy, X-ray crystallography, reactivity with electrophiles, and DFT calculations revealed that these compounds have anionic and nucleophilic character on the boron center in contrast to conventional boron-containing molecules with a Lewis acidic character. Some applications of boryl anions toward organic synthesis, organometallic chemistry, and main group chemistry are also described. © 2011 The Chemical Society of Japan. Source


Kokusho T.,Chuo University
Canadian Geotechnical Journal | Year: 2013

A dataset of undrained cyclic triaxial tests for liquefaction with parametrically changing relative density and fines content is reviewed and interpreted in the scope of energy. It is found that the strain amplitude or pore-pressure buildup during cyclic loading is uniquely correlated not only to the energy dissipated in soil specimens, but also to strain energy given from outside. Hence, an energy-based method (EBM) is developed in which liquefaction potential can be evaluated by comparing strain energy for liquefaction in a sand layer with upcoming seismic energy without regard to the differences in seismic motions. Comparative studies in soil models demonstrate that the effect of various input motions is intrinsically included in EBM, whereas it has to be considered by choosing proper coefficients in a conventional stress-based method (SBM). Another significant difference is that liquefaction potential tends to be higher for a shallower depth in EBM, while it is vice versa in SBM in a uniform sand deposit. Source


In plant organelles, RNA editing alters specific cytidine residues to uridine in transcripts. All of the site-specificity factors of RNA editing identified so far are pentatricopeptide repeat (PPR) proteins. A defect in a specific PPR protein often impairs RNA editing at multiple sites, at which the cis-acting elements are not highly conserved. The molecular mechanism for sharing a single PPR protein over multiple sites is still unclear. We focused here on the PPR proteins OTP82 and CRR22, the putative target elements of which are, respectively, partially and barely conserved. Recombinant OTP82 specifically bound to the-15 to 0 regions of its target sites. Recombinant CRR22 specifically bound to the-20 to 0 regions of the ndhB-7 and ndhD-5 sites and to the-17 to 0 region of the rpoB-3 site. Taking this information together with the genetic data, we conclude that OTP82 and CRR22 act as site-specificity factors at multiple sites in plastids. In addition, the high-affinity binding of CRR22 to unrelated cis-acting elements suggests that only certain specific nucleotides in a cis-acting element are sufficient for high-affinity binding of a PPR protein. The cis-acting elements can therefore be rather divergent and still be recognized by a single PPR protein. © 2012 The Author(s). Source


Background: Public domain databases nowadays provide multiple layers of genome-wide data e.g., promoter methylation, mRNA expression, and miRNA expression and should enable integrative modeling of the mechanisms of regulation of gene expression. However, researches along this line were not frequently executed. Results: Here, the public domain dataset of mRNA expression, microRNA (miRNA) expression and promoter methylation patterns in four regions, the frontal cortex, temporal cortex, pons and cerebellum, of human brain were sourced from the National Center for Biotechnology Informations gene expression omnibus, and reanalyzed computationally. A large number of miRNA-mediated regulation of target genes and miRNA-targeting-specific promoter methylation were identified in the six pairwise comparisons among the four brain regions. The miRNA-mediated regulation of target genes was found to be highly correlated with one or both of miRNA-targeting-specific promoter methylation and differential miRNA expression. Genes enriched for Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways that were related to brain function and/or development were found among the target genes of miRNAs whose differential expression patterns were highly correlated with the miRNA-mediated regulation of their target genes. Conclusions: The combinatorial analysis of miRNA-mediated regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can help reveal the brain region-specific contributions of miRNAs to brain function and development. © 2013 Taguchi; licensee BioMed Central Ltd. Source


Nakao Y.,Kyoto University | Hiyama T.,Chuo University
Chemical Society Reviews | Year: 2011

Much attention has been paid to the cross-coupling reaction of organosilicon compounds due to their stability, non-toxicity, and natural abundance of silicon. In addition, the silicon-based cross-coupling has many advantages over other cross-coupling protocols. Successful examples of the silicon-based cross-coupling reaction are reviewed, focusing especially on the advances made in the last decade. Having had a number of highly effective palladium catalysts developed mainly for other cross-coupling reactions, the development of the silicon-based protocol owes heavily to the design of organosilicon reagents which effectively undergo transmetalation, a key elemental step of the silicon-based cross-coupling reaction. This tutorial review thus classifies various organosilicon reagents depending on substituents on silicon and surveys their cross-coupling reactions with various electrophiles. © 2011 The Royal Society of Chemistry. Source

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