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Nagoya-shi, Japan

Hara M.,Nagoya University | Nitta Y.,Chunichi Hospital | Akiyama M.,Nagoya University
Nishinihon Journal of Dermatology | Year: 2013

A 71-year-old man had been suffering from rheumatoid arthritis for about 15 years. He noticed edema and pinkish papules on his left forearm in May 2007. He was successfully treated by administration of antibiotics in a nearby hospital. From mid-November, the similar symptoms appeared again. The skin lesions were treated with antibiotics, and his doctor introduced him to us on December 2007. At his first visit to our outpatient clinic, there were papules and edema on the left forearm. The histopathological findings included infiltration of neutrophils, presence of lymphocytes and plasma cells in the dermis and degeneration of collagen fibers. Histiocytosis and lymphangiectasia were also observed. We diagnosed that the patient was suffering from rheumatoid neutrophilic dermatitis (RND). The patient was successfully treated with prednisolone 20mg/day p.o. In the present case, we assumed that RND have accompanied to those who suffered from lymphedema. Lymphedema occur in patients with a history of RA resulting in local circulatory failure due to joint capsule swelling pressure on the periphery. As far as we examined, no other reports had shown the co-incidence of RND and localized edema. Hence, it is considered to be a valuable case. Source

Iwatsuki K.,Nagoya University | Nishikawa K.,Nagoya University | Chaki M.,Chunichi Hospital | Sato A.,Suzuka Kaisei Hospital | And 2 more authors.
Journal of Hand Surgery: European Volume | Year: 2014

This study compared the responsiveness of the Hand 20 and the Japanese version of the disabilities of the arm, shoulder and hand (DASH-JSSH) questionnaires in carpal tunnel syndrome. The scores before and 3 months after surgery were used to calculate the standardized response mean and effect size. Of 57 patients enrolled in the study, 13 underwent open carpal tunnel release and 44 had endoscopic carpal tunnel release. The standardized response mean and the effect size of the Hand 20 scale were 0.60 and 0.54, respectively, and those of the disabilities of the arm, shoulder and hand scale were 0.39 and 0.36, respectively. Compared with the Disabilities of the Arm, Shoulder and Hand questionnaire, the Hand 20 questionnaire appears to have better responsiveness for assessing the effect of treatment by carpal tunnel release. © The Author(s) 2013. Source

Shibata R.,Nagoya University | Ouchi N.,Nagoya University | Kikuchi R.,Nagoya University | Takahashi R.,Chunichi Hospital | And 6 more authors.
Atherosclerosis | Year: 2011

Objective: Obesity is closely associated with an increased risk for cardiovascular morbidity and mortality. Omentin is a fat-derived secreted factor that is downregulated in obesity. We investigated whether circulating omentin associates with the prevalence of coronary artery disease (CAD). Methods: The consecutive 78 male subjects were enrolled from patients who underwent coronary angiography. Sixty one age-matched male subjects served as controls. Plasma omentin concentration was measured by enzyme-linked immunosorbent assay. Results: Plasma levels of omentin correlated negatively with body mass index (BMI), systolic blood pressure, hemoglobin A1c and total cholesterol levels, and positively with HDL cholesterol and adiponectin levels. Circulating omentin was independently associated with hemoglobin A1c and HDL cholesterol in a multiple regression analysis. Plasma levels of omentin were markedly lower in CAD patients than in control subjects (CAD: 102.8 ± 69.0. ng/ml, control: 454.7 ± 128.6. ng/ml, P< 0.001). Multiple logistic regression analysis with BMI, systolic blood pressure, glucose, hemoglobin A1c, HDL cholesterol, adiponectin and omentin revealed that plasma omentin levels were independently correlated with CAD. Conclusion: These data indicate that low levels of omentin are closely linked with the presence of CAD and that omentin serves as a novel biomarker for CAD. © 2011 Elsevier Ireland Ltd. Source

Tanigawa T.,Aichi Medical University | Shibata R.,Nagoya University | Ouchi N.,Nagoya University | Kondo K.,Nagoya University | And 9 more authors.
Cell Death and Disease | Year: 2014

Obesity-related disorders are closely associated with the development of age-related hearing impairment (ARHI). Adiponectin (APN) exerts protective effects against obesity-related conditions including endothelial dysfunction and atherosclerosis. Here, we investigated the impact of APN on ARHI. APN-knockout (APN-KO) mice developed exacerbation of hearing impairment, particularly in the high frequency range, compared with wild-type (WT) mice. Supplementation with APN prevented the hearing impairment in APN-KO mice. At 2 months of age, the cochlear blood flow and capillary density of the stria vascularis (SV) were significantly reduced in APN-KO mice as compared with WT mice. APN-KO mice also showed a significant increase in terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells in the organ of Corti in the cochlea at 2 months of age. At the age of 6 months, hair cells were lost at the organ of Corti in APN-KO mice. In cultured auditory HEI-OC1 cells, APN reduced apoptotic activity under hypoxic conditions. Clinically, plasma APN levels were significantly lower in humans with ARHI. Multiple logistic regression analysis identified APN as a significant and independent predictor of ARHI. Our observations indicate that APN has an important role in preventing ARHI. © 2014 Macmillan Publishers Limited All rights reserved. Source

Shibata R.,Nagoya University | Takahashi R.,Chunichi Hospital | Kataoka Y.,Nagoya University | Ohashi K.,Nagoya University | And 4 more authors.
Hypertension Research | Year: 2011

Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by high-resolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT. © 2011 The Japanese Society of Hypertension All rights reserved. Source

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