Chungbuk National University and Gangneung - Wonju National University | Date: 2014-06-05
Provided is a functional cosmetic composition of white rose extract and a gartanin derivative compound isolated therefrom, and specifically, to a cosmetic composition for skin whitening and skin wrinkle alleviation containing, as active ingredients, white rose petal extract and gartanin derivative compounds isolated therefrom. The white rose extract and gartanin derivative compound, according to the present invention, are safe without causing side effects on the skin, prevent melanin production through a mechanism inhibiting tyrosinase activity, thereby having a whitening effect, and exhibit a wrinkle alleviation effect by a mechanism inhibiting MMP-1 activity, and thus the composition, of the present invention, containing the same as active ingredients, can be utilized as a material for functional cosmetics for skin whitening and wrinkle alleviation without causing skin irritation.
Chungbuk National University | Date: 2015-03-17
The present invention provides a novel use of hsvI-miR-H18 or hsv2-miR-H9-5p, which is microRNA, for the diagnosis of prostate cancer. According to hsvI-miR-H18 or hsv2-miR-H9-5p of the present invention, it is possible to accurately diagnose even a subject in the PSA gray zone in which accurate diagnosis though PSA is difficult. The present invention can be applied to various biological samples, and exerts accurate diagnostic ability even when a supernatant of the solution excluding, particularly, cell-derived materials is used, and thus a diagnostic procedure is simple and convenient. According to the present invention, the prostate cancer can be accurately and promptly diagnosed at low costs.
No S.-Y.,Chungbuk National University
Renewable and Sustainable Energy Reviews | Year: 2011
The use of inedible vegetable oils as an alternative fuel for diesel engine is accelerated by the energy crisis due to depletion of resources and increased environmental problems including the great need for edible oil as food and the reduction of biodiesel production cost, etc. Of a lot of inedible vegetable oils which can be exploited for substitute fuel as diesel fuel, seven vegetable oils, i.e., jatropha, karanja, mahua, linseed, rubber seed, cottonseed and neem oils were selected for discussion in this review paper. The application of jatropha oil as a liquid fuel for CI engine can be classified with neat jatropha oil, engine modifications such as preheating, and dual fuelling, and fuel modifications such as jatropha oil blends with other fuels, mostly with diesel fuel, biodiesel, biodiesel blends and degumming. Therefore, jatropha oil is a leading candidate for the commercialization of non-edible vegetable oils. There exists a big difference in the fuel properties of seven inedible vegetable oils and its biodiesels considered in this review. It is clear from this review that biodiesel generally causes an increase in NOx emission and a decrease in HC, CO and PM emissions compared to diesel. It was reported that a diesel engine without any modification would run successfully on a blend of 20% vegetable oil and 80% diesel fuel without damage to engine parts. This trend can be applied to the biodiesel blends even though particular biodiesel shows 40% blend. In addition, the blends of biodiesel and diesel can replace the diesel fuel up to 10% by volume for running common rail direct injection system without any durability problems. © 2010 Elsevier Ltd.
No S.-Y.,Chungbuk National University
Renewable and Sustainable Energy Reviews | Year: 2014
This review will be concentrated on the application of bio-oil produced from the cellulosic biomass among the various liquid biofuels to transport fuels, heat and power generation as substitute. Main application of bio-oil and biocrude from two main thermochemical processes, i.e., pyrolysis and liquefaction include boiler for heat and electricity production, diesel engine or gas turbine for power generation, and diesel engine for transportation fuel. Fast pyrolysis is the most popular process for converting cellulosic biomass to high yield of bio-oil with relatively low cost. For the application of bio-oils to transportation, heat and power generation, physical upgrading methods such as emulsions (bio-oil/diesel or bio-oil/biodiesel) and blends of bio-oil/oxygenated fuel (ethanol, diglyme) were mainly used and tested. The studies on the spray characteristics of emulsions and blends in diesel engine condition are not available in the literature. In most studies on the combustion and emission characteristics of emulsions and blends, CO emission was increased in most fuels and engines tested and HC was increased or comparable to diesel operation. However, NOx and soot emissions were decreased in most case of experiments. In the pressure-swirl nozzle for gas turbine application, preheating and blending techniques were employed to reduce the SMD of spray. In case of blend for the application of heat and power generation, E20 blend was mainly selected in most studies. Most studies related to bio-oil combustion in burners, diesel engines and gas turbines demonstrated the higher HC, CO and soot emissions than the original design fuel. Although the properties of bio-oil/methanol blend were widely investigated, there are no studies available about the application of bio-oil/methanol blend to transportation, heat and power generation in the literature. In addition, more research is required for the combustion of upgraded bio-oils for transportation application. © 2014 Elsevier Ltd.
No S.-Y.,Chungbuk National University
Fuel | Year: 2014
This review will be concentrated on the application of hydrotreated vegetable oils (HVO) produced from the triglycerides based biomass such as vegetable oil, animal fat, waste cooking oil and algae to compression ignition (CI) engines. Main problem in the application of HVO to CI engines is the poor low-temperature properties. The upgrading technology of cold flow properties of HVO reported in the literature can be categorized with four ways as isomerization, addition of flow improver, reaction temperature control and co-processing with petroleum derived raw materials. The advantages of hydrotreating over transesterification are lower processing cost, compatibility with infrastructure, NOx emission reduction, and feedstock flexibility. Combustion and emission characteristics of neat HVO, blends of HVO with petrodiesel and HVO with additives were widely investigated by many researchers. The use of HVO enables appreciable reductions in NOx, PM, HC and CO emissions without any changes to the engine or its control in heavy-duty engines. HVO could play an important role in providing an sustainable source of transportation fuels during the coming decades. In addition, HVO obtained from inedible vegetable oil and application of it to CI engine will be the subjects of future research in the production and application of HVO. The technologies for the reduction of NOx and PM in CI engines fuelled with HVO can be categorized with engine optimization and fuel optimization. The engine optimization technology is more effective than the fuel optimization technology. © 2013 Elsevier Ltd. All rights reserved.
Chae H.B.,Chungbuk National University
The Korean journal of hepatology | Year: 2012
Newly developed and potent antiviral agents suffer from the problem of drug resistance. Multidrug resistance is a major impediment in the treatment of patients with chronic hepatitis B (CHB). In line with American Association for the Study of Liver Diseases guidelines, adefovir dipivoxil (ADV) add-on therapy is recommended in the case of lamivudine resistance, while tenofovir disoproxil fumarate (TDF) is recommended for ADV or entecavir (ETV) resistance. TDF is currently not available in Korea. ADV+ETV combination therapy may be a viable alternative to TDF in patients with either ADV or ETV resistance. However, the efficacy of ADV+ETV combination therapy in patients with CHB and multidrug resistance is unclear. This study investigated the efficacy of ADV+ETV combination therapy in patients with multidrug resistance. Twenty-five patients were enrolled and were administered ADV+ETV combination therapy for at least 6 months. Blood was drawn at baseline and at 3, 6, 9, and 12 months after commencing treatment, and the following blood parameters were analyzed: alanine transaminase, hepatitis B e-antigen (HBeAg), anti-hepatitis B e-antigen, and hepatitis B virus (HBV) DNA levels. The initial virological response (IVR) was defined as an HBV DNA level of <4 log(10) copies/mL after 6 months of combination therapy. The IVR rate was 76%. The proportion of patients with a high viral load (≥5.0 log) dropped from 76% at baseline to only 5% after 6 months of treatment. The biochemical response rate during the first 6 months was 71%. HBeAg was lost in 2 patients (10%). ADV+ETV combination therapy induced a good IVR in CHB patients who were refractory to more than 2 antiviral agents. This regimen may be a good alternative to TDF in Korea, where that drug is not available.
Kang K.Y.,Chungbuk National University
Arthritis research & therapy | Year: 2011
Interleukin (IL)-21 is a cytokine that controls the functional activity of effector T helper cells and the differentiation of Th17 cells, and promotes B-cell differentiation. To test whether IL-21 participates in the pathogenesis of primary Sjögren's syndrome (SS), serum IL-21 level was measured and IL-21 expression in the labial salivary glands (LSG) was examined. Serum IL-21 levels in 40 primary SS, 40 rheumatoid arthritis (RA), and 38 systemic lupus erythematosus (SLE) patients and 20 healthy controls were measured. Serum IL-21 levels of SS patients were assessed for correlations with laboratory data, including anti-nuclear antibody, anti-Ro/La antibodies, globulin, immunoglobulin (Ig) class, and IgG subclass. LSGs from 16 primary SS and 4 controls with sicca symptoms were evaluated for IL-21 and IL-21 receptor (IL-21R) expression by immunohistochemistry. Confocal microscopy was performed to further characterize the IL-21 positive cells. Primary SS patients had significantly higher serum IL-21 levels than controls, and these increments correlated positively with levels of IgG, IgG1. Serum IgG1 levels correlated with anti-Ro antibody titers. Immunohistochemical analyses showed that lymphocytic foci and the periductal area of the LSGs from SS patients expressed high levels of IL-21 and lower levels of IL-21R, whereas the control LSGs showed minimal expression of both antigens. The more the lymphocyte infiltrated, IL-21 expression in LSGs showed a tendency to increase. Confocal microscopic analyses revealed that IL-21 expressing infiltrating lymphocytes in the LSGs of SS patients also expressed CXCR5. Primary SS is associated with high serum IL-21 levels that correlate positively with serum IgG, especially IgG1, levels. The expression of IL-21 is increased as more lymphocytes infiltrated in LSGs. These observations suggest that IL-21 may play an important role in primary SS pathogenesis.
Kim J.-H.,Chungbuk National University
Automatica | Year: 2011
This note considers the stability of linear systems with a time-varying delay. We are interested in a simple LyapunovKrasovskii functional (LKF) approach without delay decomposition. In this category, all recent tractable results had a fixed bound on the allowable maximum size of the delay for years. We propose a new simple LKF including the cross terms of variables and quadratic terms multiplied by a higher degree scalar function, and present a new result expressed in the form of LMIs. We show, by two well-known examples, that our result overcomes the previous allowable maximum size of delay and it is less conservative than the previous results having a relatively small upper bound in the derivative of time-delay. © 2011 Elsevier Ltd. All rights reserved.
LG Corp and Chungbuk National University | Date: 2016-04-04
The present invention relates to a method for processing an audio signal, comprising: a step of performing a frequency conversion process on an audio signal to obtain a plurality of frequency transform coefficients; a step of selecting either a general mode or a non-general mode, on the basis of a pulse ratio, for the frequency transform coefficients having a high frequency band from among the plurality of frequency transform coefficients; and a step of performing, if the non-general mode is selected, the following steps: extracting a predetermined number of pulses from the frequency transform coefficients having the high frequency band, and generating pulse information; generating an original noise signal from the frequency transform coefficients having the high frequency band, excluding the pulses; generating a reference noise signal using the frequency transform coefficient having a low frequency band from among the plurality of frequency transform coefficients; and generating noise position information and noise energy information using the original noise signal and the reference noise signal.
LG Corp and Chungbuk National University | Date: 2016-04-06
The application relates to a method for processing an audio signal including a suber wide band, the method comprising converting the audio signal into a plurality of frequency converted coefficients, determining whether to encode a high frequency band in a non tonal mode based on a harmonic-mode or non-harmonic mode determination. For the harmonic mode, encoding a position information of an harmonic track. For the non-harmonic mode encoding a fixed pulse information. A method of processing a signal encoded with an harmonic mode or non harmonic mode.