Time filter

Source Type

Lee C.T.C.,Kaohsiung Medical University | Chen V.C.H.,Chung San Medical University Hospital | Chen V.C.H.,Chung Shan Medical University | Tan H.K.L.,Taoyuan Mental Hospital | And 4 more authors.
Addictive Behaviors | Year: 2013

Aims: The present study investigates one-year incidence of mortality from suicide and other causes among heroin users in Taiwan. Design: A prospective national register-based cohort study. Setting: All heroin users who attended the methadone maintenance treatment (MMT) programs in all treatment centers in Taiwan. Participants: The sample comprised 10,842 heroin users attending MMT. Between Jan 2006 and Dec 2007, cases were identified through the multiple-center register system and followed until Dec 2008 for date and cause of death on the Taiwan national mortality database. Measurements: Standardized mortality ratios within one year of starting MMT were calculated as a ratio of actual versus expected numbers of deaths in the general population in Taiwan. Cox regression models were fitted to estimate the effects of gender, age, education and marital status as well as heroin related behaviors. Findings: In total, 256 cases died, 67 through suicide. The mortality rate (per 100 person-years) in the first year of all-cause and suicide was 1.71 and 0.45 respectively, representing 7.5- and 18.4-fold age- and gender-standardized mortality ratio (SMR) compared to the general population. Besides, the mortality rate in the first year of overdoses, murder, HIV, somatic was 0.19, 0.02, 0.07, and 0.75 respectively, representing 68.4-, 27.7-, 76.8-, and 4.3-fold SMR increases to the general population. Older age and unemployment were independent risk factors for mortality. Females had higher standardized mortality ratio than males for suicide and all-cause mortality. Conclusions: Results showed higher risk of suicide and other-cause mortality among heroin users in MMT than general population. Suicide is an important contributor to overall excess mortality among heroin users in MMT, and especially among women. Suicide prevention and physical health monitoring are important components of MMT programs. © 2013 Elsevier Ltd. Source

Wu C.-C.,Chung Shan Medical University | Wu C.-C.,Chung San Medical University Hospital | Yang T.-Y.,Taichung Veterans General Hospital | Yang T.-Y.,University of Houston | And 6 more authors.
Cell Cycle | Year: 2012

p53 plays an important role in mitotic checkpoint, but what its role is remains enigmatic. Aurora A is a Ser/Thr kinase involved in correcting progression of mitosis. Here, we show that p53 is a negative regulator for Aurora A. We found that p53 deficiency leads to Aurora A elevation. Ectopic expression of p53 or DNA damage-induced expression of p53 can suppress the expression of Aurora A. Mechanistic studies show that p53 is a negative regulator for Aurora A expression through both transcriptional and posttranslational regulation. p53 knockdown in cancer cells reduces the level of p21, which, in turn, increases the activity of CDK2 followed by induction of Rb1 hyperphosphorylation and its dissociation with transcriptional factor E2F3. E2F3 can bind to Aurora A gene promoter, potentiating Aurora A gene expression and p53 deficiency, enhancing the binding of E2F3 on Aurora A promoter. Also, p53 deficiency leads to decelerating Aurora A's turnover rate, due to the fact that p53 deficiency causes the downregulation of Fbw7α, a component of E3 ligase of Aurora A. Consistently, p53 knockdown-mediated Aurora A elevation is mitigated when Fbw7α is ectopically expressed. Thus, p53-mediated Aurora A degradation requires Fbw7α expression. Significantly, inverse correlation between p53 and Aurora A elevation is translated into the deregulation of centrosome amplification. p53 knockdown leads to high percentages of cells with abnormal amplification of centrosome. These data suggest that p53 is an important negative regulator of Aurora A, and that loss of p53 in many types of cancer could lead to abnormal elevation of Aurora A and dysregulated mitosis, which provides a growth advantage for cancer cells. © 2012 Landes Bioscience. Source

Leu S.-H.,Tsaotun Psychiatric Center | Chou J.-Y.,Taipei Medical University | Lee P.-chin.,Chung Shan Medical University | Cheng H.-C.,Tsaotun Psychiatric Center | And 6 more authors.
Asia-Pacific Psychiatry | Year: 2015

Introductions: This study aims to evaluate the validity and reliability of the Chinese version of the Sheehan Disability Scale (SDS-C) among depression patients in Taiwan. Methods: To validate the SDS-C, two samples were selected: Sample 1 (n=78) consisted of patients diagnosed with Depressive Disorder, while sample 2 (n=63) consisted of a nondepressive population. Sample 1 was evaluated with SDS twice with 7-14 days interval to measure test-retest reliability. Both samples were also evaluated with The Centre for Epidemiologic Studies Depression Scale (CESD), Family APGAR (adaptation, partnership, growth, affection, resolve) score, the Global Assessment of Functioning (GAF), and brief questionnaire of the World Health Organization Quality of Life instrument (WHOQOL-BREF) and by a psychiatrist. The two samples were combined to measure validity. Results: In concurrent validity, SDS-C scores were significantly correlated with the total score of GAF. The discriminative validity was carried out by comparing the score of SDS-C between subjects with and without current depressive disorder (t=12.32, df=139, P<0.001). Another discriminative validity by receiver-operating characteristic analysis showed the optimal cut-point was >11 (sensitivity: 82.1, specificity: 93.7). The area under the curve was 0.93 (±0.02). For the factor validity, principal components analysis showed that a single factor solution was the best solution accounting for 88.9% of the variance. Regarding the construct validity, SDS-C scores were significantly correlated with CESD, WHOQOL-BREF, and the Family APGAR score. For test-retest reliability, the intra-class correlation coefficient for the total SDS-C score was 0.89 (95% confidence interval 0.82-0.93) and internal consistency Cronbach's alpha was 0.94. Discussion: The SDS-C was found to be a valid and reliable instrument for current depressive disorder patients in Taiwan. © 2015 Wiley Publishing Asia Pty Ltd. Source

Ho M.-L.,Chung Shan Medical University | Chen P.-N.,Chung Shan Medical University | Chu S.-C.,Central Taiwan University of Science and Technology | Kuo D.-Y.,Chung Shan Medical University | And 5 more authors.
Nutrition and Cancer | Year: 2010

Anthocyanins, present in various vegetables and fruits as a nature colorant, have broad activities including anticarcinogenesis and antimutagenesis, which are generally attributed to their antioxidant activities. However, limited studies have been available concerning the inhibitory effect of peonidin 3-glucoside (P3G) for cancer metastasis. Here, we demonstrated that P3G could significantly inhibit the invasion (P < 0.001), motility (P < 0.05), secretion of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA) of lung cancer cells. Meanwhile, P3G attenuated phosphorylation of extracellular signal-regulated kinase (ERK)1/2, a member of mitogen-activated protein kinase (MAPK) family involved in the upregulation of MMPs and u-PA, and also inhibited the activation of activating protein-1 (AP-1) as shown by Western blot and electrophoretic mobility shift assay. Thus, the inhibitory effects of P3G may be at least partly through inactivation of ERK 1/2 and AP-1 signaling pathways as confirmed by abolishment of P3G-inhibited H1299 cell invasion by overexpression of MAPK kinase 1 (MEK1). Finally, P3G was evidenced by its inhibition on the metastasis of Lewis lung carcinoma cells in vivo (P < 0.001). Taken together, these findings suggested that P3G could reduce the metastasis of lung cancer cells, thereby constituting an adjuvant treatment for metastasis control. © 2010, Taylor & Francis Group, LLC. Source

Lin T.-Y.,Tsaotun Psychiatric Center | Chen V.C.H.,Chung San Medical University Hospital | Chen V.C.H.,Chung Shan Medical University | Lee C.-H.,Taipei Medical University Hospital | And 9 more authors.
Kaohsiung Journal of Medical Sciences | Year: 2013

We investigated the prevalence and correlated factors of human immunodeficiency virus (HIV) among heroin users attending methadone maintenance treatment (MMT) programs in Central Taiwan, and explored the degree of risk perception of HIV infection among the participants. Our study participants were 781 heroin users seeking treatment at the MMT program at Tsaotun Psychiatric Center in Taiwan. The presence of HIV antibodies was identified by microparticle enzyme immunoassay and confirmed by western blot. Multivariate logistic regression was used to identify the independent correlates of HIV infection. The mean age of the sample was 36.1 years [standard deviation (SD) = 7.6]; of the patients, 710 (90.9%) were men. The prevalence of HIV infection among our study population was 20.7%. Multivariate logistic regression analysis revealed that HIV infection was independently associated with the age of the patients of initial heroin use, heroin injection use, nondrug-related criminal convictions, needle-sharing behaviors, and sharing injection paraphernalia. A strong agreement existed between self-reported HIV serostatus and the results of laboratory analyses, with 88.8% of patients reporting their condition correctly. We found a high rate of HIV infection among patients in the MMT program. Factors associated with HIV infection were mostly related to drug-use behaviors. These findings stress the importance of education regarding drug-risk behaviors. © 2013, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights. Source

Discover hidden collaborations