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Taoyuan, Taiwan

Sonaje K.,National Tsing Hua University | Chen Y.-J.,National Tsing Hua University | Chen H.-L.,National Tsing Hua University | Wey S.-P.,Chang Gung University | And 6 more authors.
Biomaterials | Year: 2010

A pH-sensitive nanoparticle (NP) system composed of chitosan and poly(γ-glutamic acid) was prepared for the oral delivery of insulin. The biodistribution study in a rat model showed that some of the orally administered NPs were retained in the stomach for a long duration, which might lead to the disintegration of NPs and degradation of insulin. To overcome these problems, we freeze-dried NPs and filled them in an enteric-coated capsule. The small angle X-ray scattering (SAXS) profiles indicated that the freeze-drying process did not significantly disrupt the internal structure of NPs; additionally, their pH-sensitivity was preserved and the insulin release was pH-dependent. The results obtained in the native PAGE analysis indicated that the released insulin molecules were neither fragmented nor aggregated. Upon oral administration, the enteric-coated capsule remained intact in the acidic environment of the stomach, but dissolved rapidly in the proximal segment of the small intestine. Consequently, all the NPs loaded in the capsule were brought into the small intestine, thus enhancing the intestinal absorption of insulin and providing a prolonged reduction in blood glucose levels. The relative bioavailability of insulin was found to be approximately 20%. These results suggest that the formulation developed in the study might be employed as a potential approach for the oral delivery of insulin. © 2010 Elsevier Ltd. All rights reserved.


Dahiya D.,Chang Gung Memorial Hospital Linkou Medical Center | Wu T.-J.,Chang Gung Memorial Hospital Linkou Medical Center | Wu T.-J.,Chung Gung University | Lee C.-F.,Chang Gung Memorial Hospital Linkou Medical Center | And 3 more authors.
Surgery | Year: 2010

Background: The choice between minor versus major resection or anatomic versus nonantatomic resection for small (<5 cm) solitary hepatocellular carcinoma (HCC) in patients with cirrhosis is controversial. The aim of our study was to evaluate the long-term disease-free survival (DFS) and overall survival (OS) after minor or major hepatic resection for small solitary HCC in cirrhotic patients. Methods: Between January 1983 and December 2002, patients with solitary HCC of ≤5 cm in size who had histologically proven liver cirrhosis and microscopically tumor-free margin were included. These selected patients underwent either minor (≤2 segments) or major (≥3 segments) hepatectomy. Results: In 373 patients, 259 underwent minor and 114 underwent major hepatectomy. Patients in the minor resection group had more severe underlying liver disease (P = .005). Therefore, only 29.3% received anatomic resection in the minor resection group in comparison with 72.8% in the major hepatectomy group (P = .0001). No difference was found in postoperative morbidity (P = .105), mortality (P =.222), intrahepatic recurrence (P = .742), and 5-year DFS and OS (31.6% vs 31.8%, P = .932 and 50.7% vs 44.0%, P = .114) in both groups. The type of operative resection was not found to be a significant factor affecting survival in univariate analysis, but the preoperative liver function (alanine aminotransferase [AST] or alanine aminotransferase [ALT], serum albumin, or Child-Pugh status), tumor characteristics (alpha-feto protein, size, and presence of daughter nodules), and blood transfusion were found to be independent factors that affect the DFS and OS in a multivariate analysis. Conclusion: The severity of cirrhosis and tumor characteristics depicts long-term survival rather than the type of resection in HCC. Crown Copyright © 2010.


Yeh B.-C.,Chung Gung University
2013 Joint Conference of International Conference on Computational Problem-Solving and International High Speed Intelligent Communication Forum, ICCP and HSIC 2013 | Year: 2013

We propose one-dimensional Multi-Method codes (1-D MM codes) in spectral amplitude coding (SAC) optical code division multiple access (OCDMA) networks. The mathematical results and simulation analysis show that the MM codes in terms of the bit-error-rate (BER). The numerical results demonstrate that the 1-D MM codes outperform the existing 1-D approaches in terms of BER, and the data transmission rate can achieve 2.5 Gbps. © 2013 IEEE.


Lee S.,National Central University | Lan H.-C.,National Central University | Lee J.,Chung Gung University | Wang J.-Y.,National Dong Hwa University | And 2 more authors.
Journal of Materials Engineering and Performance | Year: 2012

A sheet metal trough of aluminum alloys is manufactured by gas-forming process at 500 °C. The product with slope walls is of ∼1.2 m long and ∼260 mm opening width, comprising two conical sinks at two ends. The depth of one sink apex is ∼350 mm, which results in the depth/width ratio reaching 1.4. To form such a complex shape with high aspect ratio, a pre-form of V-shape groove is prepared prior to the gas-forming work. When this double concave trough is turned upside down, the convex contour resembles the back of a twin hump camel. The formability of this configuration depends on the gas pressurization rate profile, the working temperature, material's micro-structure, as well as pre-form design. The latter point is demonstrated by comparing two aluminum alloys, AA5182 and SP5083, with nearly same compositions but very different grain sizes. © ASM International.


Chen W.-C.,Chang Gung University | Tsai Y.-H.,Chang Gung University | Weng H.-H.,Chang Gung University | Wang S.-C.,Chang Gung University | And 3 more authors.
Journal of Computer Assisted Tomography | Year: 2014

OBJECTIVE: Imaging the brachial plexus is a challenge because of its complicated structure. The purpose of this study is to improve the diagnostic ability for brachial plexus via 3-dimensional T2-weighted short inversion time inversion recovery (3D-T2-STIR) technique with contrast agent administration. METHODS: Thirty patients with brachial plexopathies were recruited. The STIR sequences without and with contrast agent administration were performed on each subject. The grade of the diagnostic ability and the contrast ratio were assessed. RESULTS: After contrast agent administration, signals of the adjacent vessels were suppressed because of reduced T1 relaxation time similar to that of fat tissues. The outlines of nerves would be prominent with respect to surrounding tissues. Both diagnostic ability and contrast ratio were improved on 3D-T2-STIR with contrast agent administration. CONCLUSIONS: The maximum-intensity projection image of 3D-T2-STIR technique with contrast agent was superior to that without. It might be a better way to evaluate anatomies and pathologies of the brachial plexus. These advantages would improve the understanding and neurosurgical planning for brachial plexopathies in the future. Copyright © 2014 by Lippincott Williams &Wilkins.

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